395 research outputs found

    A symbolic emulator for shuffle synthesis on the NVIDIA PTX code

    Get PDF
    Various kinds of applications take advantage of GPUs through automation tools that attempt to automatically exploit the available performance of the GPU's parallel architecture. Directive-based programming models, such as OpenACC, are one such method that easily enables parallel computing by just adhering code annotations to code loops. Such abstract models, however, often prevent programmers from making additional low-level optimizations to take advantage of the advanced architectural features of GPUs because the actual generated computation is hidden from the application developer. This paper describes and implements a novel flexible optimization technique that operates by inserting a code emulator phase to the tail-end of the compilation pipeline. Our tool emulates the generated code using symbolic analysis by substituting dynamic information and thus allowing for further low-level code optimizations to be applied. We implement our tool to support both CUDA and OpenACC directives as the frontend of the compilation pipeline, thus enabling low-level GPU optimizations for OpenACC that were not previously possible. We demonstrate the capabilities of our tool by automating warp-level shuffle instructions that are difficult to use by even advanced GPU programmers. Lastly, evaluating our tool with a benchmark suite and complex application code, we provide a detailed study to assess the benefits of shuffle instructions across four generations of GPU architectures.We are funded by the EPEEC project from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 801051 and the Ministerio de Ciencia e Innovación-Agencia Estatal de Investigación (PID2019-107255GB-C21/AEI/10.13039/501100011033). This work has been partially carried out on the ACME cluster owned by CIEMAT and funded by the Spanish Ministry of Economy and Competitiveness project CODEC-OSE (RTI2018-096006-B-I00).Peer ReviewedPostprint (published version

    Proposals of a procedure to asses Pollutographs. Application to Murcia's Combined Sewer Overflows (CSOs). Póster

    Get PDF
    Directives 91/271/EEC and 93/481/EEC set norms regarding the management of Combined Sewer Overflows. European Commission monitors the implementation status and implementation programmes. In fact, during the year 2019 all the utilities should be able to quantify the pollution spilled during storm events. And afterwards, plans have to be developed in order to reduce the impact of such events. In this paper, we proposed a method to estimate the transported pollution during events as well as to serve as a tool for developing plans to lessen the corresponding pollution. The procedure is divided into three steps: A. Periodical measurements of all relevant pollutants, e.g. total suspended solids and chemical oxygen demand, in wet and dry weather. Such pollutant “concentrations” are correlated with the turbidity, updating the relation among them [1]. B. Continuous measures of the turbidity. Turbidity is continously register in the sewer areas near overflow spillways. Turbidimeters are a very convenient equipment for this purpose [2]. Actually, it is reliable, its measures are very correlated with the total suspended solid concentration and its maintenance is easy. In this way, combining A. and B. turbidity measures provide us a real-time estimation of the pollutant concentration. on real time. C. Assesment of each catchment hydrograph. Depending on the available data, this step could be based on a design, a measured or a simulated hydrograph. In order to apply this methodology to Murcia’s Combined Sewer System, we have used simulated hydrographs based on real measured rainfall. Murcia’s utility has developed a calibrated SWMM model, and therefore, using the rainfall data, it is possible to estimate hydrographs for all the relevant points of the system. D. Estimation of each catchment pollutograph. Combining the pollutant concentration, estimated in the previous steps, with the hydrographs, we can asses how the mass of pollutants are transported. This information allows us to comply with EU Directives, but it will also be useful to design Murcia’s strategy to minimize environmental impacts

    Evaluating energy recovery potential in Murcia's water supply system

    Get PDF
    Murcia is the 7th most populated city in Spain. Its water supply system is extensively monitored through a large number of pressure gauges and flow meters. Murcia’s water supply network is fed from distribution reservoirs at enough elevation to avoid needing pumping stations for most of the city districts. Hydraulic resources have been evaluated throughout the water supply system. Besides the pressure reducing valves, where the assessment is quite straight forward [1], District Metered Areas (DMA) inlets have been evaluated. In these areas despite the hydraulic resources are not as great as in pressure reducing valves locations, their location is quite convenient. Actually, these positions are located inside the city, therefore making easy to use the produced energy in municipal self consumption or to provide facilities to the citizens. In order to perform such evaluation, a detailed model of the water supply network has been implemented in EPANET parting from a GIS model. The first step of the evaluation has consisted in the optimizing and validation of the model. Initially, the model was reviewed by comparing pressure and flow rate measurements in the main pipes. Then, an extensive experimental campaign was designed. In that campaign valves were switched so that each day a set of District Metered Areas (DMA) have just one metered inlet or at the most a very short number of metered inlets, whereas having a set of pressure measurements within the DMA. The obtained data was used to minimize errors in pressure time series, optimising roughness of the main pipes through Levenberg/Marquardt BFGS algorithm using EPANET ToolKit through Epanet-Octave [2]. Important roughness proposed changes tended to be located surrounding particular points, where errors in the GIS were located (mainly wrong diameter assignement). After patching all the errors the algorithm eased to localise, model errors were mostly below measures uncertainty, and therefore, the model was considered validated. Then, the hydraulic potential at the DMAs inlets has been evaluated by tracking the “instantaneous” minimum pressure and head within each DMA, as well as the flow rate entering the DMA. So that, the maximum head and the range of flow rates is established for the turbine. At the moment, once that all of these potentials have been assessed, a turbine prototype is being designed

    Interdigital tissue regression in the developing limb of vertebrates

    Get PDF
    ABSTRACT Here we we have chosen the regression of the interdigital tissue which sculpts the digits from the hand/foot plate in tetrapod embryos to review the most relevant aspects concerning the regulation and biological significance of programmed cell death. We gather abundant information showing that the initiation of the degenerative process is the result of a complex interplay between the different signaling pathways which are also responsible for limb outgrowth and skeletal tissue differentiation, rather than being regulated by a specific signaling pathway. The model further shows that once the death response is triggered, several different routes of cell disruption, including caspase-dependent apoptosis, lysosomal-mediated cell death, and even a cell senescence process, are activated in the interdigits to ensure their elimination. Transcriptional and structural changes accompanying the degenerative process, and their posible contribution to the control of the death process, are also revised in detail. Finally we survey a number of issues still awaiting clarification, such as the functional implication of interdigital cell death as a source of signals acting on the surrounding tissues, as occurs in the so called “regenerative cell death”

    Gestión del patrimonio arqueológico en las dunas de Guardamar del Segura: La Fonteta y la Rábita (Guardamar del Segura, Alicante, España)

    Full text link
    [ES] El yacimiento arqueológico de “Las Dunas de Guardamar” constituye una de las zonas arqueológicas de mayor relevancia patrimonial, tanto de la Comunitat Valenciana como del Mediterráneo Occidental. Localizado en Guardamar del Segura (provincia de Alicante, Comunitat Valenciana, España), integra a “La Fonteta”, uno de los enclaves portuarios fenicios mejor conservados, esencial para el estudio de la Protohistoria Antigua en el Sureste ibérico, y a “La Rábita”, el ribāṭ de época califal más completo y conocido en el territorio peninsular. Tiene la consideración jurídica de Bien de Interés Cultural, con categoría de Zona Arqueológica, declarado con la denominación de “La Rábita Califal de las Dunas”. El valor patrimonial del conjunto motivó el interés de la Conselleria de Educación, Cultura y Deporte, a través de la Dirección General de Cultura y Patrimonio, para desarrollar el Proyecto de consolidación y puesta en valor de la zona arqueológica de las Dunas de Guardamar. Con este artículo, queremos poner a disposición de la comunidad científica, los resultados de las actuaciones desarrolladas durante la ejecución del citado Proyecto, que se gestó a partir de 2014 y se pudo ejecutar entre 2019 y 2021. Para esta tarea resultó fundamental el apoyo institucional y económico, de varios organismos de la propia Generalitat Valenciana, del Ayuntamiento de Guardamar del Segura y de forma indirecta de varios organismos de la administración del Estado.López Mira, JA.; Simón García, JL. (2023). Gestión del patrimonio arqueológico en las dunas de Guardamar del Segura: La Fonteta y la Rábita (Guardamar del Segura, Alicante, España). Editorial Universitat Politècnica de València. 123-133. https://doi.org/10.4995/Icomos2022.2022.1539612313

    Cellulose Biosynthesis Inhibitors: Comparative Effect on Bean Cell Cultures

    Get PDF
    [EN] The variety of bioassays developed to evaluate different inhibition responses for cellulose biosynthesis inhibitors makes it difficult to compare the results obtained. This work aims (i) to test a single inhibitory assay for comparing active concentrations of a set of putative cellulose biosynthesis inhibitors and (ii) to characterize their effect on cell wall polysaccharides biosynthesis following a short-term exposure. For the first aim, dose-response curves for inhibition of dry-weight increase following a 30 days exposure of bean callus-cultured cells to these inhibitors were obtained. The compound concentration capable of inhibiting dry weight increase by 50% compared to control (I50) ranged from subnanomolar (CGA 325′615) to nanomolar (AE F150944, flupoxam, triazofenamide and oxaziclomefone) and micromolar (dichlobenil, quinclorac and compound 1) concentrations. In order to gain a better understanding of the effect of the putative inhibitors on cell wall polysaccharides biosynthesis, the [14C]glucose incorporation into cell wall fractions was determined after a 20 h exposure of cell suspensions to each inhibitor at their I50 value. All the inhibitors tested decreased glucose incorporation into cellulose with the exception of quinclorac, which increased it. In some herbicide treatments, reduction in the incorporation into cellulose was accompanied by an increase in the incorporation into other fractions. In order to appreciate the effect of the inhibitors on cell wall partitioning, a cluster and Principal Component Analysis (PCA) based on the relative contribution of [14C]glucose incorporation into the different cell wall fractions were performed, and three groups of compounds were identified. The first group included quinclorac, which increased glucose incorporation into cellulose; the second group consisted of compound 1, CGA 325′615, oxaziclomefone and AE F150944, which decreased the relative glucose incorporation into cellulose but increased it into tightly-bound cellulose fractions; and the third group, comprising flupoxam, triazofenamide and dichlobenil, decreased the relative glucose incorporation into cellulose and increased it into a pectin rich fraction.SISpanish Ministry of Science and Innovation programs ( AGL2011-30545-C02-02)This work was partly supported by grants from Junta de Castilla y León (LE 48A07

    Characterization of the Alpha-Beta and Martensitic Transformations en the Ti-6Al-2Sn-4Zr-6Mo Alloy

    Full text link
    A Ti–6Al–2Sn–4Zr–6Mo (wt.%) alloy has been subjected to different thermal treatments of solution and aging leading to different amounts and distribution of untransformed _-phase, _-phase and martensite. In order to study the _-phase transformation, and thus to evaluate its kinetic behaviour, its characteristics and its influence in subsequent transformations, dilatometric analysis tests, metallographic studies, hardness, and conductivity measurements have been performed

    Metallurgical Control And Social Power. The Bronze Age Communities Of High Guadalquivir (Spain)

    Get PDF
    This research project is centered on lbe archaeometallurgic process lbat was developed by Bronze Age communities in tbe High Guadalquivir (Spain). Copper, bronze and silver mining and metallurgic transformations constitute one of tbe bases of tbe historie develapment of tbese communities.· Such activity implies tbe use of more complex technologies and lbe control of tbe distribution of tbese new products by tbe aristoeratic groups. The fieldwork carried out in lbe site of Peilalosa (Bailos de la Encina, provinee of Jaen, Spain) has produced a great deal of archaeologieal n';mains showing tbe complexity of tbe metallurgical process in Recent Prehistory. Excavations at Peilalosa have allowed us to carry out archaeometaJlurgical research in relation to: 1. The sequence ofmelallurgical aetivity. 2. The ascription ofthis activity and its different phases to different vilJage areas. 3. Use of different stone raw materials to creale lbe necessary tools for lbe metallurgical process and differenl minerals (malachile, azurile, galena, etc.) to be fused. 4. General aecess to metallurgieal pracesses (found in al! tbe dwellings) and tbeir praduels (presenl in a great number of tombs, especially in relation to daggers and swords). 5. Differenees in tbe size of tbe weapons located in tbe differenl lombs. 6. Restricted access to non-copper minerals and, overall, lo items made witb preciaus metals.Archeometallurgical Project: Bronze Age Communities 01 the High Guadalquivir (BHA2000-1512), funded by tbe Ministry of Seience and TeehnologyPeñalosa Project, funded by the Ministry of Culture of the Autonomaus Community of Andalusí

    Apoptosis during embryonic tissue remodeling is accompanied by cell senescence

    Get PDF
    This study re-examined the dying process in the interdigital tissue during the formation of free digits in the developing limbs. We demonstrated that the interdigital dying process was associated with cell senescence, as deduced by induction of β-gal activity, mitotic arrest, and transcriptional up-regulation of p21 together with many components of the senescence-associated secretory phenotype. We also found overlapping domains of expression of members of the Btg/Tob gene family of antiproliferative factors in the regressing interdigits. Notably, Btg2 was up-regulated during interdigit remodeling in species with free digits but not in the webbed foot of the duck. We also demonstrate that oxidative stress promoted the expression of Btg2, and that FGF2 and IGF1 which are survival signals for embryonic limb mesenchyme inhibited Btg2 expression. Btg2 overexpression in vivo and in vitro induced all the observed changes during interdigit regression, including oxidative stress, arrest of cell cycle progression, transcriptional regulation of senescence markers, and caspase-mediated apoptosis. Consistent with the central role of p21 on cell senescence, the transcriptional effects induced by overexpression of Btg2 are attenuated by silencing p21. Our findings indicate that cell senescence and apoptosis are complementary processes in the regression of embryonic tissues and share common regulatory signals
    corecore