Sex differences in ochratoxin a toxicity in F344 rats after 7 and 21 days of daily oral administration

Ochratoxin A (OTA) is a potent renal carcinogen in male rats but not in females. The mechanisms underlying these differences are unknown. The sex-dependent response of F344 rats after a repeated OTA oral administration for 7 (0.50 mg/kg bw) or 21 days (0.21 and 0.50 mg/kg bw) was evaluated. General toxicity, sex and thyroid hormones and histopathology were studied. OTA was quantified (HPLC-FLD) in plasma, kidney and liver and the expression of kidney transporters (RT-qPCR) was studied. After 7 days, kidney histopathology showed more pronounced signs of toxicity in males than in females. After 21 days, a higher toxicity was observed but sex differences disappeared. OTA concentration in plasma and tissues was similar in both sexes. Downregulation was the general OTA-induced effect. Oats' downregulation was slow in males and Oat3 did not change in females. Oatp1 was strongly downregulated in males after 21 days. An opposite effect was observed in Bcrp after 21 days: downregulation in males and upregulation in females. Females showed a dose- and time-dependent decrease of progesterone. Despite the sex differences, the final balance in OTA toxicokinetics at renal cell level does not seem to support a higher accumulation of OTA in male kidneys

Probing neutrino masses with future galaxy redshift surveys

We perform a new study of future sensitivities of galaxy redshift surveys to the free-streaming effect caused by neutrino masses, adding the information on cosmological parameters from measurements of primary anisotropies of the cosmic microwave background (CMB). Our reference cosmological scenario has nine parameters and three different neutrino masses, with a hierarchy imposed by oscillation experiments. Within the present decade, the combination of the Sloan Digital Sky Survey (SDSS) and CMB data from the PLANCK experiment will have a 2-sigma detection threshold on the total neutrino mass close to 0.2 eV. This estimate is robust against the inclusion of extra free parameters in the reference cosmological model. On a longer term, the next generation of experiments may reach values of order sum m_nu = 0.1 eV at 2-sigma, or better if a galaxy redshift survey significantly larger than SDSS is completed. We also discuss how the small changes on the free-streaming scales in the normal and inverted hierarchy schemes are translated into the expected errors from future cosmological data.Comment: 14 pages, 7 figures. Added results with the KAOS proposal and 1 referenc

Determinants of self-rated health perception in a sample of a physically active population: PLENUFAR VI study

The aim of this study was to investigate determinants of self-rated health (SRH) perception in Spanish adults. This cross-sectional study including data from 11,342 participants from the Spanish PLENUFAR VI study. SRH status was grouped in two categories ('good'/'poor') and the associations of socio-demographic characteristics, lifestyles, diet adequacy and chronic disease with SRH were assessed. After adjusting for relevant confounders, the risk ratios (RR) and (95% confidence intervals) for poor SRH were 1.05 (1.03-1.07) for each hour of increment of sitting, 1.56 (1.30-1.88) for short (>= 5 h vs. 7-8 h) sleep duration, 0.63 (0.55-0.72) for vigorous (vs. light) physical activity, 0.61 (0.50-0.74) for adequate (vs. non-adequate) diet. Activities like jogging [RR for each unit of increment in the METs-h/day = 0.87 (0.82-0.92)], gymnastics [0.87 (0.81-0.93)], biking [0.91 (0.85-0.98)], and track and field [0.94 (0.89-0.98)], were associated with better health perception. Normally weight participants with any chronic disease had lower probability to report poor SRH than overweight/obese participants with any chronic disease. Frequent consumption of bread (>2 servings/day) was associated with a lower adjusted mean of health perception scale, while higher consumption of vegetables and fruit or fish were associated with higher values, concerning good SRH. We can conclude that normal-weight participants even suffering a chronic disease had lower probability to report poor health perception than participants with overweight/obesity and a chronic disease especially for hypertension and diabetes. Activities like jogging, gymnastics, biking, and track and field, and a higher consumption of fruits, vegetables and fish, were associated with better health rated perception

The lithium stellarator experiment. TJ-II as a benchmark

In the last years, lithium wall conditioning has been carried out in several fusion devices (Tokamaks, Compact Toruses) by different techniques, providing in many instances record values of plasma parameters and enhanced plasma reproducibility. Behind these findings are the low recycling, low contamination and non-coronal enhanced radiative power dissipation properties of Li. Stellarators are best suited for reactor concepts as far as they basically free from extreme thermal load events. However, the potential problem of impurity accumulation must be taken into account. Therefore, the use of low Z elements as PFC would be highly desirable. In the present work, the plasma performance of the TJ-II Heliac under Li-coated wall conditions with lithium is described. Compared to previous coatings, lithium has produced the best plasma performance to date, leading to the achievement of record values in plasma density and energy confinement. In the present work, the impact of the Li coating operation on reactor relevant issues, such as particle exhaust and retention, high-density operation, confinement characteristics and plasma wall interaction issues is stressed.На протязі останніх років обробку стінок літієм було проведено в кількох термоядерних установках (токамаки, компактні тори) з використанням різних методів, що забезпечило у багатьох випадках одержання плазми з рекордними параметрами та покращеним відтворенням результатів. Ці результати пов’язані з низьким рециклінгом, що властивий літію, слабким забрудненням плазми і підвищеним не корональним поглинанням випромінювання. Стеларатори краще за все підходять для концепції реактора, бо в них у принципі не може бути підвищених теплових навантажень. Але треба враховувати можливість накопичення домішок. Тому конче бажано в поверхнях, які повернені до плазми, використовувати елементи з низьким Z. В даній роботі описано експерименти по одержанню плазми в геліаку TJ-II в умовах покриття стінок літієм. Порівняно з покриттями, що використовувалися раніше, літій забезпечив одержання плазми з найкращими на даний час параметрами, дозволивши досягти рекордних значень гущини плазми та утримання енергії. Підкреслена важливість літієвого покриття для таких аспектів реактора, як втрати і затримування частинок, робота при високій гущині, характеристики утримання та взаємодія плазма-стінка.В течение последних лет обработка стенок литием была проведена в нескольких термоядерных установках (токамаки, компактные торы) с использованием различных методов, что обеспечило во многих случаях получение плазмы с рекордными параметрами и улучшенной воспроизводимостью результатов. Эти результаты связаны со свойственными литию низким рециклингом, слабым загрязнением плазмы и повышенным не корональным поглощением излучения. Стеллараторы лучше всего подходят для концепции реактора, ибо у них в принципе не может быть повышенных тепловых нагрузок. Однако, необходимо учитывать возможность накопления примесей. Поэтому весьма желательно в поверхностях, обращённых к плазме, использовать элементы с низким Z. В настоящей работе описаны эксперименты по получению плазмы в гелиаке TJ-II в условиях покрытия стенок литием. По сравнению с покрытиями, которые использовались раньше, литий обеспечил получение плазмы с наилучшими в настоящее время параметрами, позволив достичь рекордных значений плотности плазмы и удержания энергии. Подчёркивается важность литиевого покрытия для таких аспектов реактора, как расход и удерживание частиц, работа при большой плотности, характеристики удержания и взаимодействие плазма-стенка

Comparison of two strategies for the start-up of a biological reactor for the treatment of hypersaline effluents from a table olive packaging industry

Biological treatment of hypersaline effluents with high organic matter concentrations is difficult to carry out and it can require a long start-up phase. This is the case of the treatment of fermentation brines from the table olive packaging (FTOP) industries. These effluents are characterized by conductivity values around 90 mS/cm, COD around 15,000 mg/L and total phenols concentration around 1000 mg/L. In this work, FTOP has been treated in two sequencing batch reactors (SBRs) operated in parallel. In each SBR a different start-up strategy has been carried out. In the SBR-2, biomass was previously acclimated to high salinity using simulated wastewater without phenolic compounds, meanwhile in the SBR-1, FTOP was added from the beginning of the start-up. Results indicated more operational problems in the SBR-2 consisting in a higher deflocculation that drove to high turbidity values in the effluent. Besides, at the end of the start-up, the SBR-1 reached higher COD removal efficiencies than SBR-2 (88% and 73%, respectively). In both reactors, an increase in gamma-Proteobacteria in the microbial population was observed for increasing conductivities. In addition, phenols were completely removed in both reactors at the end of the start-up, what implied very low toxicity values in the effluent.The authors of this work thank the financial support of CDTI (Centre for Industrial Technological Development) depending on the Spanish Ministry of Science and Innovation.Ferrer-Polonio, E.; Mendoza Roca, JA.; Iborra Clar, A.; Alonso Molina, JL.; Pastor Alcañiz, L. (2015). Comparison of two strategies for the start-up of a biological reactor for the treatment of hypersaline effluents from a table olive packaging industry. Chemical Engineering Journal. 273:595-602. doi:10.1016/j.cej.2015.03.062S59560227

Constraints on Higgs boson production with large transverse momentum using H →b b ¯ decays in the ATLAS detector

This paper reports constraints on Higgs boson production with transverse momentum above 1 TeV. The analyzed data from proton-proton collisions at a center-of-mass energy of 13 TeV were recorded with the ATLAS detector at the Large Hadron Collider from 2015 to 2018 and correspond to an integrated luminosity of 136 fb-1. Higgs bosons decaying into bb¯ are reconstructed as single large-radius jets recoiling against a hadronic system and are identified by the experimental signature of two b-hadron decays. The experimental techniques are validated in the same kinematic regime using the Z→bb¯ process. The 95% confidence-level upper limit on the cross section for Higgs boson production with transverse momentum above 450 GeV is 115 fb, and above 1 TeV it is 9.6 fb. The Standard Model cross section predictions for a Higgs boson with a mass of 125 GeV in the same kinematic regions are 18.4 fb and 0.13 fb, respectively

Measurement of the polarisation of single top quarks and antiquarks produced in the t-channel at √s = 13 TeV and bounds on the tWb dipole operator from the ATLAS experiment

A simultaneous measurement of the three components of the top-quark and top-antiquark polarisation vectors in t-channel single-top-quark production is presented. This analysis is based on data from proton–proton collisions at a centre-of-mass energy of 13 TeV corresponding to an integrated luminosity of 139 fb, collected with the ATLAS detector at the LHC. Selected events contain exactly one isolated electron or muon, large missing transverse momentum and exactly two jets, one being b-tagged. Stringent selection requirements are applied to discriminate t-channel single-top-quark events from the background contributions. The top-quark and top-antiquark polarisation vectors are measured from the distributions of the direction cosines of the charged-lepton momentum in the top-quark rest frame. The three components of the polarisation vector for the selected top-quark event sample are Px′ = 0.01 ± 0.18, Py′ = −0.029 ± 0.027, Pz′ = 0.91 ± 0.10 and for the top-antiquark event sample they are Px′ = −0.02 ± 0.20, Py′ = −0.007 ± 0.051, Pz′ = 0.79 ± 0.16. Normalised differential cross-sections corrected to a fiducial region at the stable-particle level are presented as a function of the charged-lepton angles for top-quark and top-antiquark events inclusively and separately. These measurements are in agreement with Standard Model predictions. The angular differential cross-sections are used to derive bounds on the complex Wilson coefficient of the dimension-six O operator in the framework of an effective field theory. The obtained bounds are C ∈ [−0.9, 1.4] and C ∈ [−0.8, 0.2], both at 95% confidence level. [Figure not available: see fulltext.]

A search for an unexpected asymmetry in the production of e(+)mu(-) and e(-)mu(+) pairs in proton-proton collisions recorded by the ATLAS detector at root s=13 TeV

This search, a type not previously performed at ATLAS, uses a comparison of the production cross sections for e(+)mu(-) and e(-)mu(+) pairs to constrain physics processes beyond the Standard Model. It uses 139 fb(-1) of proton-proton collision data recorded at root s = 13 TeV at the LHC. Targeting sources of new physics which prefer final states containing e(+)mu(-) and e(-)mu(+), the search contains two broad signal regions which are used to provide model-independent constraints on the ratio of cross sections at the 2% level. The search also has two special selections targeting supersymmetric models and leptoquark signatures. Observations using one of these selections are able to exclude, at 95% confidence level, singly produced smuons with masses up to 640 GeV in a model in which the only other light sparticle is a neutralino when the R-parity-violating coupling lambda(23)(1)' is close to unity. Observations using the other selection exclude scalar leptoquarks with masses below 1880 GeV when g(1R)(eu) = g(1R)(mu c) = 1, at 95% confidence level. The limit on the coupling reduces to g(1R)(eu) = g(1R)(mu c) = 0.46 for a mass of 1420 GeV

Study of Bc+→J/ψDs+ and Bc+→J/ψDs∗+ decays in pp collisions at √s = 13 TeV with the ATLAS detector

A study of Bc+→J/ψDs+ and Bc+→J/ψDs∗+ decays using 139 fb of integrated luminosity collected with the ATLAS detector from s = 13 TeV pp collisions at the LHC is presented. The ratios of the branching fractions of the two decays to the branching fraction of the Bc+→ J/ψπ decay are measured: B(Bc+→J/ψDs+)/B(Bc+→J/ψπ+) = 2.76 ± 0.47 and B(Bc+→J/ψDs∗+)/B(Bc+→J/ψπ+) = 5.33 ± 0.96. The ratio of the branching fractions of the two decays is found to be B(Bc+→J/ψDs∗+)/B(Bc+→J/ψDs∗+) = 1.93 ± 0.26. For the Bc+→J/ψDs∗+ decay, the transverse polarization fraction, Γ/Γ, is measured to be 0.70 ± 0.11. The reported uncertainties include both the statistical and systematic components added in quadrature. The precision of the measurements exceeds that in all previous studies of these decays. These results supersede those obtained in the earlier ATLAS study of the same decays with s = 7 and 8 TeV pp collision data. A comparison with available theoretical predictions for the measured quantities is presented. [Figure not available: see fulltext.]