725 research outputs found
Robust 24 Hours ahead Forecast in a Microgrid: A Real Case Study
Forecasting the power production from renewable energy sources (RESs) has become fundamental in microgrid applications to optimize scheduling and dispatching of the available assets. In this article, a methodology to provide the 24 h ahead Photovoltaic (PV) power forecast based on a Physical Hybrid Artificial Neural Network (PHANN) for microgrids is presented. The goal of this paper is to provide a robust methodology to forecast 24 h in advance the PV power production in a microgrid, addressing the specific criticalities of this environment. The proposed approach has to validate measured data properly, through an effective algorithm and further refine the power forecast when newer data are available. The procedure is fully implemented in a facility of the Multi-Good Microgrid Laboratory (MG(Lab)(2)) of the Politecnico di Milano, Milan, Italy, where new Energy Management Systems (EMSs) are studied. Reported results validate the proposed approach as a robust and accurate procedure for microgrid applications
Multi-Scale Analysis of Agricultural Drought Propagation on the Iberian Peninsula Using Non-Parametric Indices
Understanding how drought propagates from meteorological to agricultural drought requires further research into the combined effects of soil moisture, evapotranspiration, and precipitation, especially through the analysis of long-term data. To this end, the present study examined a multi-year reanalysis dataset (ERA5-Land) that included numerous drought events across the Iberian Peninsula, with a specific emphasis on the 2005 episode. Through this analysis, the mechanisms underlying the transition from meteorological to agricultural drought and its features for the selected region were investigated. To identify drought episodes, various non-parametric standardized drought indices were utilized. For meteorological droughts, the Standardized Precipitation-Evapotranspiration Index (SPEI) was employed, while the Standardized Soil Moisture Index (SSI), Multivariate Standardized Drought Index (MSDI), and Standard Precipitation, Evapotranspiration and Soil Moisture Index (SPESMI) were utilized for agricultural droughts, while their ability to identify relative vegetation stress in areas affected by severe droughts was investigated using the Fraction of Absorbed Photosynthetically Active Radiation (FAPAR) Anomaly provided by the Copernicus European Drought Observatory (EDO). A statistical approach based on run theory was employed to analyze several characteristics of drought propagation, such as response time scale, propagation probability, and lag time at monthly, seasonal, and six-month time scales. The retrieved response time scale was fast, about 1–2 months, and the probability of occurrence increased with the severity of the originating meteorological drought. The duration of agricultural drought was shorter than that of meteorological drought, with a delayed onset but the same term. The results obtained by multi-variate indices showed a more rapid propagation process and a tendency to identify more severe events than uni-variate indices. In general terms, agricultural indices were found to be effective in assessing vegetation stress in the Iberian Peninsula. A newly developed combined agricultural drought index was found to balance the characteristics of the other adopted indices and may be useful for future studies
MAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma
Background
The high incidence and mortality of lung tumours is a major health problem. Therefore, the identification both of biomarkers predicting efficacy for therapies in use and of novel efficacious therapeutic agents is crucial to increase patient survival. MAP17 (PDZK1IP1) is a small membrane-bound protein whose upregulation is reported as a common feature in tumours from diverse histological origins. Furthermore, MAP17 is correlated with tumour progression.
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Methods
We assessed the expression of MAP17 in preclinical models, including cell lines and patient-derived xenografts (PDXs), assessing its correlation with sensitivity to different standard-of-care drugs in lung adenocarcinoma, as well as novel drugs. At the clinical level, we subsequently correlated MAP17 expression in human tumours with patient response to these therapies.
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Results
We show that MAP17 expression is induced during lung tumourigenesis, particularly in lung adenocarcinomas, and provide in vitro and in vivo evidence that MAP17 levels predict sensitivity to therapies currently under clinical use in adenocarcinoma tumours, including cisplatin, carboplatin and EGFR inhibitors. In addition, we show that MAP17 expression predicts proteasome inhibitor efficacy in this context and that bortezomib, an FDA-approved drug, may be a novel therapeutic approach for MAP17-overexpressing lung adenocarcinomas.
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Conclusions
Our results indicate a potential prognostic role for MAP17 in lung tumours, with particular relevance in lung adenocarcinomas, and highlight the predictive pot0065ntial of this membrane-associated protein for platinum-based therapy and EGFR inhibitor efficacy. Furthermore, we propose bortezomib treatment as a novel and efficacious therapy for lung adenocarcinomas exhibiting high MAP17 expression
Soil P and cation availability and crop uptake in a forage rotation under conventional and reduced tillage
Long-term conservation tillage can modify vertical distribution of nutrients in soil profiles and alter nutrient availability and yields of crops
Impact of fire and post-fire management techniques on soil chemical properties
The effects of
fire (
Control
burned soil) and two emergency stabilisation techniques (grass
Seeding
and straw
Mulching
) on 20 chemical characteristics were evaluated on 0
–
5 cm top-soils sampled 1, 90, 180 and
365 days after an experimental
fi
re in a steep shrubland of a temperate-humid region (NW Spain). Most
part of pH (in H
2
O and KCl) variance was explained by the sampling date. No clear temporal trends were
identi
fi
able for total soil C and N content, likely due to the large SOM pool in these soils; however, changes
on soil
δ
13
C were explained by the deposition of
13
C-depleted ashes, followed by its progressive erosion,
while those on soil
δ
15
N were a consequence of
fi
re induced N outputs. After the
fi
re, NH
4
+
–
N, P, Na, K, Mg,
Ca, Mn, Cu, Zn and B concentrations increased, while those of NO
3
−
–
N, Al, Fe and Co did not vary significantly.
Despite a significant decline with time, concentrations of Mg, Ca and Mn at the end of the study were still
higher than in unburned soil, while those of K, Cu, Zn and B were similar to the pre-fire levels and those of
NH
4
+
–
N, P and Na were below pre-fire values.
Mulching
and
Seeding
treatments for burned soil emergency
stabilisation had significant effects on soil
δ
15
N and extractable K, Mg and Ca, while data were inconclusive
for their possible effects on the extractable Al, Fe and C
Soil pH effects on the Toxicity of zinc oxide nanoparticles to soil bacterial communities.
The environmental levels of ZnO nanoparticles (nZnO) are increasing continually given the widespread and expanding applications of this material. Soil pH appears to be one of the key factors affecting the behavior and toxicity of metal nanoparticles in soi
Reduction of Nutrient Losses with Eroded Sediments by Post-Fire Soil Stabilisation Techniques
After an experimental fire in steep shrub land in a temperate–humid region (north-west Spain), the effects of
two post-fire stabilisation treatments (grass seeding and straw mulching) on the chemical properties of eroded sediments,and the amount of nutrients lost with them, we reevaluated relative to control burnt soil, over a period of 13 months. Total C
and N concentrations, and
d
13
C, indicated that sediments were mainly contributed by charred plant and litter material. The
highest concentrations of extractable base cations in the sediments occurred during the first 3 months following fire,
especially for Na and K. As treatments had little or no effect on nutrient concentration in sediments, differences in nutrient
losses were due to the 10-fold lower sediment production in mulching compared with other treatments. In control and
seeding treatments, the accumulated amounts of nutrients lost with sediments were 989–1028kgha
1
(C), 77kgha
1
(N),
1.9–2.4kgha
1
(Ca), 0.9–1.1kgha
1
(Mg), 0.48–0.55kgha
1
(NH
4
þ
–N), 0.39–0.56kgha
1
(K), 0.19–0.34kgha
1
(Na)
and
,
0.1kgha
1
(P and NO
3
–N)
.
These values accounted for 22–25% (total C and N) and 5–12% (NH
4
þ
–N, Ca, P and
Mg) of available nutrients in ash, and 1.0–2.4% of those in ash
þ
topsoil. As nutrient and sediment losses were strongly
correlated, the reduction of the latter by mulching application leads to an effective decrease of post-fire nutrient losses
N2O emissions and N efficiency due to tillage systems and crop rotation under a rainfed Mediterranean agroecosystem
Application of nitrogen (N) fertilizers in agricultural
soils increases the risk of N loss to the atmosphere in the form of ammonia (NH3), nitrous oxide (N2O) and nitric oxide (NO)and the water bodies as nitrate (NO3-). The implementation of agricultural management practices can affect these losses. In Mediterranean irrigation systems, the greatest losses of NO3-through leaching occur within the irrigation and the intercropperiod. One way to abate these losses during the intercrop period is the use of cover crops that absorb part of the residual N from the root zone (Gabriel and Quemada, 2011). Moreover, during the following crop, these species could be applied as
amendments to the soil, providing both C and N to
the soil. This effect of cover and catch crops on
decreasing the pool of N potentially lost has focused primarily on NO3-leaching. The aim of this work was to evaluate the effect of cover crops on N2O emission during the in tercrop period in a maize system and its subsequent incorporation into the soil in the following maize crop
Influence of denitrifiers abundance on N2O emissions in long term tillage system under a rainfed legume crop
Current studies about nitrous oxide (N2O) emissions from legume crops have raised considerable doubt, observing a high variability between sites (0.03-7.09 kg N2O–N ha−1 y
-1) [1]. This high variability has been associated to climate and soil conditions, legume species and soil management practices (e.g. conservation or conventional tillage). Conservation tillage (i.e. no tillage (NT) and minimum tillage (MT)) has spread during the last decades because promotes several positive effects (increase of soil organic content, reduction of soil erosion and enhancement of carbon (C) sequestration). However, these benefits
could be partly counterbalanced by negative effects on the release of N2O emissions. Among processes responsible for N2O production and consumption in soils, denitrification plays an importantrole both in tilled and no-tilled ropping systems [2]. Recently, amplification of functional bacterial genes involved in denitrification is being used to examine denitrifiers abundance and evaluate their influence on N2O emissions. NirK and nirS are functional genes encoding the cytochrome cd1 and copper nitrite reductase, which is the key enzyme regulating the denitrification process
Septicemic salmonellosis caused by Salmonella Hessarek in wintering and migrating song thrushes (turdus philomelos) in Spain
We investigated two mortality events in wintering and migrating Song Thrushes (Turdus philomelos) in Catalonia, northeastern Spain in 2009 and 2010. Both episodes occurred in late February to mid-March during the spring migration. Salmonellosis produced by the serotype Salmonella enterica subsp. enterica serotype Hessarek (S. Hessarek) was identified as the cause of death in both episodes. Poor body condition, marked splenomegaly, and microscopic disseminated intravascular coagulation with numerous intravascular and tissular bacteria were the most consistent findings. Macro-restriction profiling by pulsed-field gel electrophoresis (PFGE) using XbaI was performed for epidemiologic typing of the S. Hessarek isolates. Two clusters were discernible, that are possibly related, with a similarity of 82.8%. Analysis comparing pectoral muscle and subcutaneous fat scores from the Song Thrushes that died from S. Hessarek with those from healthy Song Thrushes from nearby areas during 2009 and 2010 suggest that poor body condition was associated with the S. Hessarek infection
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