Procedimiento y sistema de identificación de elementos identificadores móviles y lector y elemento identificador móvil utilizados en dicho procedimiento

Número de publicación: 2 291 097 Número de solicitud: 200503124Procedimiento para identificar elementos identificadores móviles (504, 506) por un lector (500) que emite una señal de radio maestra dentro de un canal, comprendiendo el procedimiento las siguientes etapas: (a) el lector (500) interroga a los elementos identificadores (506) que pasan por el área de cobertura (502) durante un tiempo superior a un tiempo mínimo de paso, para que respondan durante un tiempo acotado de identificación, y (b) cada elemento identificador (506) envía su señal de identificación dentro de un intervalo de identificación del tiempo acotado de identificación. Se caracteriza por el hecho de que cada elemento identificador (506) sale de manera independiente de un estado dónde no observa el canal, cuya duración es inferior al tiempo mínimo de paso, para observar el canal.Universidad Politécnica de Cartagen

Desarrollo Económico de la Comarca de Cartagena 2016

El presente informe tiene la finalidad de servir como una herramienta de diagnóstico de la situación económica del tejido empresarial de la Comarca de Cartagena, promoviendo medidas que contribuyen al desarrollo estratégico de la Comarca. A partir del estudio y análisis del contexto socioeconómico sectorial que han realizado los investigadores especialistas en cada uno de los sectores de actividad, así como del análisis por parte de los paneles de expertos consultados, se incluye a continuación un estudio por sectores de actividad de las actuaciones que deberían considerarse para establecer las líneas estratégicas de contenido económico en la Comarca de Cartagena en los próximos años. Las políticas que permitan desarrollar dichas actuaciones asegurarán la competitividad de las pequeñas y medianas empresas en general y el adecuado progreso económico de la Comarca en particular. Los principales pilares de competitividad sobre los que deberían asentarse las actuaciones estratégicas para la comarca se han clasificado por sectores de actividad atendiendo a las infraestructuras, el conocimiento (formación y cualificación), el desarrollo de las tecnologías de la información y las comunicaciones, la innovación, la financiación y la eficiencia de las Administraciones Públicas. El informe se estructura en una primera aproximación a la situación macroeconómica de la Comarca en su contexto Regional y Nacional desde el punto de vista de la oferta y la demanda, así como un detalle prospectivo de la economía para los próximos meses. A continuación se detalla el análisis sectorial dividido en los sectores: turismo, comercio, industria, agroalimentación y tecnológico. Adicionalmente, se incluye un análisis y diagnóstico económicofinanciero a nivel microeconómico de las pymes de la Comarca. Por último, se incluyen a modo de resumen las principales conclusiones y recomendaciones derivadas del estudi

Multicentre, randomised, single-blind, parallel group trial to compare the effectiveness of a Holter for Parkinson's symptoms against other clinical monitoring methods: study protocol

Introduction In recent years, multiple studies have aimed to develop and validate portable technological devices capable of monitoring the motor complications of Parkinson's disease patients (Parkinson's Holter). The effectiveness of these monitoring devices for improving clinical control is not known. Methods and analysis This is a single-blind, cluster-randomised controlled clinical trial. Neurologists from Spanish health centres will be randomly assigned to one of three study arms (1:1:1): (a) therapeutic adjustment using information from a Parkinson?s Holter that will be worn by their patients for 7 days, (b) therapeutic adjustment using information from a diary of motor fluctuations that will be completed by their patients for 7 days and (c) therapeutic adjustment using clinical information collected during consultation. It is expected that 162 consecutive patients will be included over a period of 6 months. The primary outcome is the efficiency of the Parkinson?s Holter compared with traditional clinical practice in terms of Off time reduction with respect to the baseline (recorded through a diary of motor fluctuations, which will be completed by all patients). As secondary outcomes, changes in variables related to other motor complications (dyskinesia and freezing of gait), quality of life, autonomy in activities of daily living, adherence to the monitoring system and number of doctor?patient contacts will be analysed. The noninferiority of the Parkinson's Holter against the diary of motor fluctuations in terms of Off time reduction will be studied as the exploratory objective. Ethics and dissemination approval for this study has been obtained from the Hospital Universitari de Bellvitge Ethics Committee. The results of this study will inform the practical utility of the objective information provided by a Parkinson's Holter and, therefore, the convenience of adopting this technology in clinical practice and in future clinical trials. We expect public dissemination of the results in 2022.Funding This work is supported by AbbVie S.L.U, the Instituto de Salud Carlos III [DTS17/00195] and the European Fund for Regional Development, 'A way to make Europe'

PhDAY 2020 -FOO (Facultad de Óptica y Optometría)

Por cuarto año consecutivo los doctorandos de la Facultad de Óptica y Optometría de la Universidad Complutense de Madrid cuentan con un congreso propio organizado por y para ellos, el 4º PhDAY- FOO. Se trata de un congreso gratuito abierto en la que estos jóvenes científicos podrán presentar sus investigaciones al resto de sus compañeros predoctorales y a toda la comunidad universitaria que quiera disfrutar de este evento. Apunta en tu agenda: el 15 de octubre de 2020. En esta ocasión será un Congreso On-line para evitar que la incertidumbre asociada a la pandemia Covid-19 pudiera condicionar su celebración

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Genomic investigations of unexplained acute hepatitis in children

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children

Estudia el Grado en Turismo en la Universidad Politécnica de Cartagena

Estudia Grado en Turismo en la Universidad Politécnica de Cartagen

Accumbal dopamine, noradrenaline and serotonin activity after naloxone-conditioned place aversion in morphine-dependent mice

Dopamine (DA) neurons not only show a pattern signaling the magnitude, delay and probability of rewards but also code negative motivation and aversive events. Beside DA, other systems such as noradrenaline (NA) and serotonin (5-HT) may also be implicated in naloxone-induced conditioned place aversion (CPA; an index of the aversive consequences of withdrawal). The purpose of the present study was to evaluate: (i) the turnover of DA, NA and 5-HT in the nucleus accumbens (NAc), one of the most important substrates for aversive states, (ii) the changes in tyrosine hydroxylase (TH) gene expression in the ventral tegmental area, and (iii) total TH protein levels and TH phosphorylation in the NAc after naloxone-induced morphine withdrawal. DA, NA and 5-HT turnover was evaluated by high-performance liquid chromatography (HPLC). TH gene expression was determined by real time quantitative PCR (RT-PCR) and total TH and TH phosphorylated at Ser31 and Ser40 were analyzed by Western blot. Present results show that the aversion for environmental cues paired with opioid withdrawal was higher than that observed in the saline group treated with naloxone, which indicates that morphine pretreatment potentiated the ability of naloxone to produce place aversion. In addition, present data show that naloxone-induced CPA positively correlated with an increase of DA and NA turnover in the NAc, which paralleled an increase in TH gene expression in the VTA and TH phosphorylation and enhanced TH protein levels in the NAc. Thus, the present study indicates that naloxone-induced aversion in morphine-dependent mice enhances DA and NA activity in the NAc and suggests that transcriptional and post-transcriptional regulation of TH could be involved in the hyperactivity of mesolimbic dopaminergic system observed in morphine-withdrawn mice. © 2012 Elsevier Ltd. All rights reserved.This work was supported by Ministerio de Ciencia e Innovación, Spain (Grants SAF/FEDER 2009-07178; 2010-17907), Red de Trastornos Adictivos (RTA; RD06/0001/1006) and Fundación Séneca, Agencia Regional de Ciencia y Tecnología, Región de Murcia (15405/PI/10) and Instituto Murciano de Investigación Biosanitaria (IMIB).Peer Reviewe