Trasplante de mano y miembro superior. Una mirada bioética desde un país de ingreso mediano

Tissue transplantation has developed rapidly since its introduction in the last century, saving and transforming hundreds of thousands of lives around the world. The transplant of nonessential tissue such as the hand entails a special ethical conflict, given the high financial cost, the need for resources from health systems and the need for immunosuppressive medication for the recipient. The main aspects related to the possibility of introducing this type of intervention in a middle-income country are discussed.El trasplante de tejidos ha tenido un rápido e importante desarrollo desde su introducción en el siglo pasado, por lo que se ha convertido en un procedimiento que permite salvar y transformar miles de vidas alrededor del mundo. El trasplante de tejido no esencial, como la mano, conlleva un conflicto ético especial debido al alto costo financiero que acarrea, la alta demanda de recursos de los sistemas de salud que requiere y la necesidad de suministrar al receptor medicamentos inmunosupresores que implica. De esta forma, en el presente artículo se discuten los principales aspectos relacionados con la posibilidad de introducir programas para este tipo de intervención en un país de ingreso mediano como Colombia

A simple DC-UPS based in forward-forward topology, design and simulation

This paper presents the analysis, design and simulation of a simple DC-UPS converter with integrated back-up and automatic transition. This converter makes automatic transitions between the main AC and the battery when a failure occurs; and it delivers uninterrupted DC power to the load through two independent power sources of commercial input power and battery power. The converter has the following characteristics: automatic transition between the main and the battery, no additional control to detect failure in main, single structure, galvanic isolation, multi output voltages capability and only one switch control for two operation modes: normal and back-up. The analysis, design and simulation for this converter are presented

Isolated DC-DC UPS based in a forward-forward converter analysis and design

This paper presents the analysis, design and simulation from a simple DC-UPS converter with integrated back-up and automatic transition. This converter makes automatic transition between the main AC and the battery when a failure occurs, and it delivers uninterrupted DC power to the load through two independent power sources of commercial input power and battery power. The converter has the following characteristics: automatic transition between the main and the battery, no additional control to detect failure in the main, single structure, galvanic isolation, multi output voltages capability and only one switch control for two operation modes normal and back-up. The analysis, design, simulation and experimental results for this converter are presented

Variable phenotype in HNF1B mutations: extrarenal manifestations distinguish affected individuals from the population with congenital anomalies of the kidney and urinary tract

Background: Mutations in hepatocyte nuclear factor 1B (HNF1B) have been associated with congenital anomalies of the kidney and urinary tract (CAKUT) in humans. Diabetes and other less frequent anomalies have also been described. Variable penetrance and intrafamilial variability have been demonstrated including severe prenatal phenotypes. Thus, it is important to differentiate this entity from others with similar clinical features and perform confirmatory molecular diagnosis. Methods: This study reports the results of HNF1B screening in a cohort of 60 patients from 58 unrelated families presenting with renal structural anomalies and/or non-immune glucose metabolism alterations, and other minor features suggesting HNF1B mutations. Results: This study identified a pathogenic variant in 23 patients from 21 families. The most frequent finding was bilateral cystic dysplasia or hyperechogenic kidneys (87% of patients). Sixty percent of them also fulfilled the criteria for impaired glucose metabolism, and these were significantly older than those patients with an HNF1B mutation but without diabetes or prediabetes (14.4 versus 3.3years, P<0.05). Furthermore, patients with HNF1B mutations had higher frequency of pancreatic structural anomalies and hypomagnesaemia than patients without mutations (P<0.001 and P = 0.003, respectively). Hyperuricaemia and increased liver enzymes were detected in some patients as well. Conclusions: Renal anomalies found in patients with HNF1B mutations are frequently unspecific and may resemble those found in other renal pathologies (CAKUT, ciliopathies). Active searching for extrarenal minor features, especially pancreatic structural anomalies or hypomagnesaemia, could support the indication for molecular diagnosis to identify HNF1B mutations

Ruthenium catalysis in biological habitats

Dedicated to Prof. Janine CossyRecent years have witnessed a considerable progress in research aimed at merging transition metal catalysis with chemical and cell biology. Therefore, a crescent number of metal-catalyzed transformations have been shown compatible with biological media and even with living settings. Of the different transition metals used to build these biocompatible catalysts, ruthenium has demonstrated to be particularly powerful, in part because the resulting complexes exhibit a very good balance between reactivity and biological stability. Indeed, ruthenium complexes have demonstrated utility to promote a great variety of reactions in biologically relevant contexts, from deprotection and redox processes to cycloadditions or photocatalytic transformations. Many of these reactions may enable the development of new type of biological tools and pharmacological strategiesPID2020-118579GB−I00; PID2019-108624RB−I00; Consellería de Cultura, Educación e Ordenación Universitaria-Grant Numbers: ED431 C 2021/25, ED431G 2019/03; European Union; Ministerio de Universidades. Grant Number: FPU17/00711S

Single-Board-Computer Clusters for Cloudlet Computing in Internet of Things

The number of connected sensors and devices is expected to increase to billions in the near future. However, centralised cloud-computing data centres present various challenges to meet the requirements inherent to Internet of Things (IoT) workloads, such as low latency, high throughput and bandwidth constraints. Edge computing is becoming the standard computing paradigm for latency-sensitive real-time IoT workloads, since it addresses the aforementioned limitations related to centralised cloud-computing models. Such a paradigm relies on bringing computation close to the source of data, which presents serious operational challenges for large-scale cloud-computing providers. In this work, we present an architecture composed of low-cost Single-Board-Computer clusters near to data sources, and centralised cloud-computing data centres. The proposed cost-efficient model may be employed as an alternative to fog computing to meet real-time IoT workload requirements while keeping scalability. We include an extensive empirical analysis to assess the suitability of single-board-computer clusters as cost-effective edge-computing micro data centres. Additionally, we compare the proposed architecture with traditional cloudlet and cloud architectures, and evaluate them through extensive simulation. We finally show that acquisition costs can be drastically reduced while keeping performance levels in data-intensive IoT use cases.Ministerio de Economía y Competitividad TIN2017-82113-C2-1-RMinisterio de Economía y Competitividad RTI2018-098062-A-I00European Union’s Horizon 2020 No. 754489Science Foundation Ireland grant 13/RC/209

Eco-innovation and management in time of crisis: a comparative analysis of environmental good practices and labour productivity in the spanish hotel industry (2008-2012)

The economic crisis in recent years has significantly affected the Spanish hospitality industry. Some factors that affect labor productivity and therefore business performance in this sector may have affected the productivity in a different way when the economic crisis in Spain became deeper. One such factor is the eco-innovation. In previous works, the authors of this paper have used a variable that holds a set of good environmental practices to analyze the impact of the introduction of eco-innovation measures on labor productivity. The variable "good environmental practice" is an indicator of environmental management and has been introduced in a widely used production function. The main objective of the present work is to compare the impact of that variable on labor productivity into two different times (2008 and 2012) to verify the changes that have occurred as a result of the economic crisis. This analysis was performed for a sample of 173 hotels in Andalusia in 2008 and 181 in 2012.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Evaluating the role of gamification and flow in e-consumers: millennials versus generation X

This research has three main objectives. First, it examines influence of gamification on the behavioral intention to use an e-commerce platform. Second, it analyzes the role of the flow state given its importance in terms of behavior in online environments. Finally, the study aims to detect and analyze differences between Millennials and Generation X.Es la versión enviada del artículo. Se puede consultar la versión final en https://doi.org/10.1108/K-07-2018-035

El hándicap del transporte aéreo para el desarrollo inicial del turismo de masas en las Islas Canarias

Air transport has played a significant role in the development of mass tourism in the sixties and seventies, especially in a fragmented territory and away as the Canary Islands. Thus, without the advent of the jet engine to the Canary Islands, can’t understand the spectacular development of tourism in the islands during this period. Thus the main objective of this paper, is to show the decisive role of air transport for tourism development in the Canary Islands.El transporte aéreo, más aún en un territorio fragmentado y alejado como es el caso del Archipiélago canario, ha jugado un papel trascendental para el desarrollo del turismo de masas en los años sesenta y setenta. En efecto, sin la llegada del motor a reacción a Canarias, no se podría comprender el espectacular desarrollo turístico que las Islas experimentaron en este periodo, siendo el principal objetivo de este trabajo, abordar —aunque de forma sucinta—, este proceso absolutamente decisivo para las Islas