De la bibliometría al emprendimiento: un estudio de estudios

Bibliometric studies of entrepreneurship as a discipline have contributed fundamentally to the creation of a certain order in an apparently chaotic and contradictory literature, examining how the discipline has developed, giving a comprehensive vision of the structure of the field, observing its social networks, detecting trends, discovering knowledge gaps and helping to plan future research lines. The purpose of this article is to explore this special type of research. In terms of methodology, it uses an adaptation of the Systematic Literature Review, and a content analysis using text-mining software in order to look deeper into objectives, conclusions and limitations. Among the main findings, there is some evidence that indicates that the image presented to date about entrepreneurship has not considered the multidisciplinary nature of the field and could, therefore, be distorted. At the same time, a series of inherent problems have been detected, and it has become evident that there is a need to incorporate the latest advances in bibliometrics and to improve collaboration between experts from both fields in order to solve those mentioned issues and move towards future progress.Los estudios bibliométricos sobre emprendimiento como disciplina académica han contribuido fundamentalmente a crear orden en una literatura aparentemente caótica y contradictoria, examinan su desarrollo y dan una visión integral de la estructura del campo, observan sus redes sociales, detectan tendencias, descubren brechas de conocimiento y ayudan a planificar futuras líneas de investigación. El objetivo de este artículo es explorar este tipo especial de investigación. Desde el punto de vista metodológico se utiliza una adaptación del proceso de revisión sistemática de la literatura y un análisis de contenido a través de software de minería de textos para profundizar en objetivos, conclusiones y limitaciones de este tipo de análisis. Entre los principales hallazgos encontramos evidencias que indican que la imagen ofrecida hasta la fecha sobre el emprendimiento no ha considerado la naturaleza multidisciplinaria del campo y, por tanto, podría estar distorsionada. A su vez, se detectan una serie de problemas inherentes a su desarrollo, se hace evidente la necesidad de incorporar los últimos avances en bibliometría, mejorando la colaboración entre expertos de ambos campos para resolverlos y avanzar hacia el progreso futuro

Caracterización de los clásicos del emprendimiento (1968-2016). Un análisis basado en la Web of Science

The aim of this paper is to broaden the analysis of entrepreneurship as a field of study by employing a bibliographical search of works which constitute the “classics” of entrepreneurship and by examining their underlying “knowledge base” (cited works) as well as the reasons why they are characterised as such. H-Classics methodology was applied in the selection of these classic works and a thorough analysis of documents, citing and cited authors as well as journals was carried out. The results obtained in the process help isolate the sources that may determine which works could be seen as truly representative of the discipline of entrepreneurship and, more importantly, to find out which of them are more likely to embody the paradigms required in order to make a clear definition of what constitutes entrepreneurship as a discipline.Este trabajo tiene como objetivo profundizar en el análisis del campo del emprendimiento mediante la búsqueda bibliográfica de los trabajos que se configuran como “clásicos del emprendimiento” y su caracterización, así como la del “conocimiento base” (trabajos citados) en que se apoyan los mismos. Se aplica la metodología H-Classics para seleccionar estos trabajos clásicos y se realiza un análisis en profundidad de documentos, autores citantes y citados y revistas. Los resultados alcanzados llevan a aislar las fuentes que permitirían determinar qué obras podrían constituir la disciplina del emprendimiento y lo que es más importante, cuáles cuentan con mayor “probabilidad” de mostrar aquellos paradigmas necesarios para conformarla

Myxofibroma of the maxilla. Reconstruction with iliac crest graft and dental implants after tumor resection

Odontogenic fibromyxomas are benign odontogenic tumors of mesenchymal origin of rare presentation in the oral cavity, which exhibit locally aggressive behavior and are prone to local recurrence. The controversy has mainly been on therapeutic management with recommendations varying, depending on the clinical cases, from simple curettage of lesion to segmental bone resection. We present a case report describing the reconstruction of an osseous defect in the maxilla and the restoration with dental implants in a 32 year old female patient after radical surgical excision due to an odontogenic fibromyxoma with locally aggressive behavior. The primary reconstruction of maxillary discontinuity defect was carried out by an immediate non-vascularized cortico-cancellous iliac crest graft. Using a computer-guided system for the implant treatment-planning, three dental implants were secondary placed in the bone graft by means of flapless implant surgery. The patient was subsequently restored with an implant-supported fixed prosthesis that has remained in continuous function for a period of three years. The surgical, reconstructive and restorative treatment sequence and techniques are discussed. © Medicina Oral S. L

Protein delivery based on uncoated and chitosan-coated mesoporous silicon microparticles

Mesoporous silicon is a biocompatible, biodegradable material that is receiving increased attention for pharmaceutical applications due to its extensive specific surface. This feature enables to load a variety of drugs in mesoporous silicon devices by simple adsorption-based procedures. In this work, we have addressed the fabrication and characterization of two new mesoporous silicon devices prepared by electrochemistry and intended for protein delivery, namely: (i) mesoporous silicon microparticles and (ii) chitosan-coated mesoporous silicon microparticles. Both carriers were investigated for their capacity to load a therapeutic protein (insulin) and a model antigen (bovine serum albumin) by adsorption. Our results show that mesoporous silicon microparticles prepared by electrochemical methods present moderate affinity for insulin and high affinity for albumin. However, mesoporous silicon presents an extensive capacity to load both proteins, leading to systems were protein could represent the major mass fraction of the formulation. The possibility to form a chitosan coating on the microparticles surface was confirmed both qualitatively by atomic force microscopy and quantitatively by a colorimetric method. Mesoporous silicon microparticles with mean pore size of 35 nm released the loaded insulin quickly, but not instantaneously. This profile could be slowed to a certain extent by the chitosan coating modification. With their high protein loading, their capacity to provide a controlled release of insulin over a period of 60-90 min, and the potential mucoadhesive effect of the chitosan coating, these composite devices comprise several features that render them interesting candidates as transmucosal protein delivery systems

OptEEmAL: Decision-Support Tool for the Design of Energy Retrofitting Projects at District Level

Designing energy retrofitting actions poses an elevated number of problems, as the definition of the baseline, selection of indicators to measure performance, modelling, setting objectives, etc. This is time-consuming and it can result in a number of inaccuracies, leading to inadequate decisions. While these problems are present at building level, they are multiplied at district level, where there are complex interactions to analyse, simulate and improve. OptEEmAL proposes a solution as a decision-support tool for the design of energy retrofitting projects at district level. Based on specific input data (IFC(s), CityGML, etc.), the platform will automatically simulate the baseline scenario and launch an optimisation process where a series of Energy Conservation Measures (ECMs) will be applied to this scenario. Its performance will be evaluated through a holistic set of indicators to obtain the best combination of ECMs that complies with user's objectives. A great reduction in time and higher accuracy in the models are experienced, since they are automatically created and checked. A subjective problem is transformed into a mathematical problem; it simplifies it and ensures a more robust decision-making. This paper will present a case where the platform has been tested.This research work has been partially funded by the European Commission though the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No 680676. All related information to the project is available at https://www.opteemal-project.eu

El trastorno autista: un análisis de los aspectos asociados (I)

[Resumen] A través de esta comunicación pretendemos resumir de la manera más clara posible nuestro propio estudio del trastorno autista enmarcado dentro de los trastornos generalizados del desarrollo. Esto, a su vez, nos servirá de introducción para una investigación que sobre diferentes patologías y trastornos del lenguaje estamos llevando a cabo. Además, queremos transmitir una serie de aspectos asociados al autismo reflejados en 37 sujetos que asisten a centros específicos de ASPANAES (Asociación de Pais de Persoas Autistas e Psicóticas da Provincia da Coruña) de Castelo Culleredo, Ferrol, Santiago, y As Pontes. Describimos aspectos tales como, prevalencia, sexo, patrón falniliar, clase social, funcionamiento intelectual, epilepsia y sistema sensorioperceptiv

Low-Temperature Synthesis of a PtRu/Nb0.1Ti0.9O2 Electrocatalyst for Methanol Oxidation

Niobium was doped into anatase TiO2 support at 10 mol % (Nb0.1Ti0.9O2) using sol-gel chemistry. A PtRu/Nb0.1Ti0.9O2 catalyst was synthesized by LiBH4 reduction in tetrahydrofuran. The methanol electro-oxidation activity of the catalyst shows that this oxide support was electrically conductive. The current (A/gPt) was 6% higher on the PtRu/Nb0.1Ti0.9O2 catalyst compared to a commercial PtRu/C catalyst at 25°C. The electrochemically active surface area of the PtRu/C was 94% higher than PtRu/Nb0.1Ti0.9O2, thus the current per active site was 100% higher on PtRu/Nb0.1Ti0.9O2. A membrane electrode assembly with PtRu/Nb0.1Ti0.9O2 had 46% higher current (A/gPt) than an equivalent E-TEK membrane electrode assembly at 70°C

Pegylated lipid nanocapsules with improved drug encapsulation and controlled release properties

Drugs with poor lipid and water solubility are some of the most challenging to formulate in nanocarriers, typically resulting in low encapsulation efficiencies and uncontrolled release profiles. PEGylated nano- capsules (PEG-NC) are known for their amenability to diverse modifications that allow the formation of domains with different physicochemical properties, an interesting feature to address a drug encapsulation problem. We explored this problem by encapsulating in PEG-NC the promising anticancer drug candidate F10320GD1, used herein as a model for compounds with such characteristics. The nanocarriers were pre- pared from Miglyol®, lecithin and PEG-sterate through a solvent displacement technique. The resulting system was a homogeneous suspension of particles with size around 200 nm. F10320GD1 encapsulation was found to be very poor (<15%) if PEG-NC were prepared using water as continuous phase; but we were able to improve this value to 85% by fixing the pH of the continuous phase to 9. Interestingly, this modification also improved the controlled release properties and the chemical stability of the formulation during storage. These differences in pharmaceutical properties together with physicochemical data sug- gest that the pH of the continuous phase used for PEG-NC preparation can modify drug allocation, from the external shell towards the inner lipid core of the nanocapsules. Finally, we tested the bioactivity of the drug-loaded PEG-NC in several tumor cell lines, and also in endothelial cells. The results indicated that drug encapsulation led to an improvement on drug cytotoxicity in tumor cells, but not in non-tumor en- dothelial cells. Altogether, the data confirms that PEG-NC show adequate delivery properties for F10320GD1, and underlines its possible utility as an anticancer therapy.The authors would like to acknowledge financial support from CENIT-NANOFAR XS53 project, FAES Farma S.A. (Spain), Xunta de Galicia (Competitive Reference Ref. GRC2014/043, FEDER Funds) and the European Commission FP7 EraNet — EuroNanoMed Program-Instituto Carlos III (Lymphotarg pro- yect, Ref. PS09/02670). MGF was a recipient of an Isidro Parga Pondal contract

Modelos de gestión en nutrición clínica. Puntos débiles y puntos fuertes

En el VIº Foro de Debate Abbott-SENPE se establece una discusión multidisciplinar y multiprofesional para buscar el o los modelos de gestión clínica que consideramos más adecuados para la Unidades de Nutrición Clínica y Dietética (UNCyD) en España. Se valoran los puntos débiles y fuertes así como las oportunidades de los actuales sistemas y se concluye en la observación de una cierta disparidad vinculada no solo a las comunidades autónomas sino también a los diferentes tipos de hospital. Se propone, desde SENPE, la creación de un grupo de trabajo que ayude a la normalización de los modelos y a potenciar la cultura del Cuadro de Mandos Integral y de Gestión del Cambio.At the 6th Abbott-SENPE Debate Forum a multidisciplinary and multiprofessional discussion was established in order to seek for the model or the models of clinical management most appropriate for Clinical Nutrition and Dietetics Units (CNAD) in Spain. The weaknesses and strengths as well as opportunities for the current systems were assessed concluding that a certain degree of disparity was observed not only due to regional differences but also to different hospital types. It was proposed, from SENPE, the creation of a working group helping to standardize the models and promote the culture of Integral Control and Change Management