Impacto social, médico, emocional y espiritual relacionado al grado de confinamiento por COVID-19 en el adulto mayor

Objetivo: Investigar si el estado de confinamiento por COVID-19 tiene un impacto en los aspectos sociales, médicos, emocionales y espirituales en las personas mayores. Métodos: Estudio transversal, de septiembre a octubre de 2020 en Nuevo León, México, que incluyó a un total de 247 adultos mayores de ≥60 años que viven en la comunidad, que asisten a una clínica geriátrica. Los participantes completaron un instrumento estructurado de recopilación de datos vía telefónica, documentando datos demográficos, experiencias con COVID-19 y telesalud, el Inventario de Recursos Sociales Díaz-Veiga, la Escala de Actividad Física para Ancianos (PASE), el Cuestionario de Salud del Paciente-9 (PHQ-9), el Índice de Religión de la Universidad de Duke (DUREL). Los participantes se dividieron en dos grupos según su estado de confinamiento: grupo Confinado y No confinado. Resultados: De 247 participantes, el 20.6% conformó el grupo no confinado y el 79.4% el grupo confinado. La edad media fue de 71.9 ± 8.2 años. Las mujeres (59%, p=0.01) están más confinadas y las que viven solas (10.5%, p=0,001) estaban menos confinadas. El grupo no confinado fue consultado en menor proporción (80,4%, p<0,001). Los participantes confinados se sintieron más satisfechos con la consulta de telesalud (87,2%, p<0,001). Nuestra población no mostró una diferencia significativa en las puntuaciones de depresión. Se utilizaron actividades religiosas no organizacionales (NORA) diarias para hacer frente al confinamiento (67%, p=0,04). Conclusiones: El confinamiento tuvo un impacto en el aspecto social, médico y espiritual de las personas mayores. Nuestro estudio demostró que los adultos mayores que viven en la comunidad se adaptan al nuevo acceso a la atención médica, permaneciendo resilientes, autónomos y satisfaciendo las necesidades espirituales a pesar del confinamiento. Palabras clave: Adultos mayores, Confinamiento, COVID-19, Teleconsult

Urinary protein detection by iTRAQ® associated with renal transplant complications and its modification with therapy

AbstractBackgroundAfter renal transplant, surgical, infection complications, as well as graft rejection may occur; early detection through non-invasive markers is the key to change therapy and avoid biopsy.ObjectiveThe aim of the study is to determine urine protein profiles in patients undergoing renal transplant with complications and detect its variation when therapy is modified.Material and methodsUrine samples were collected from patients prior the transplant and various postoperative stages. Urinary protein profiles were obtained by peptide labelling using isobaric isotopes for relative quantification (iTRAQ®).ResultsA total of 22 patients were included, of whom 12 developed post-transplant complication: 2 with graft rejection (1 male and 1 female) and 10 (6 males and 4 females) in the group of post-transplant infections. Using iTRAQ® 15/345 and 28/113 proteins were identified and fulfilled the acceptance criteria, in graft rejection and post-transplant infections group, respectively.ConclusionsAlbumin was the only protein found in both groups, the remaining proteins were different. The five proteins with higher scores in graft rejection were: alpha-1-microglobulin, 5′-nucleotidase cytosolic III, retinol-binding protein 4, membrane protein palmitoylated 4, and serine carboxypeptidase, while post-transplant infections were: mitochondrial acetyl-coenzyme A synthetase, putative adenosyl homocysteinase 2, zinc finger protein GLIS1, putative protein FAM157B, and zinc finger protein 615. It remains to elucidate the involvement of each of these in patients with renal transplantation

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele