199 research outputs found
Lattices of classes of groupoids with one-sided quasigroup conditions
It is shown that two classes of groupoids satisfying certain one-sided quasigroup conditions, namely the classes of one-sided torsion groupoids and of one-sided finite exponent groupoids, are complete lattices, both isomorphic to the lattice of Steinitz numbers with the divisibility relation
Implication of membrane androgen receptor (ZIP9) in cell senescence in regressed testes of the bank vole
Can nuclear weapons fallout mark the beginning of the Anthropocene Epoch?
Many scientists are making the case that humanity is living in a new geological epoch, the Anthropocene, but
there is no agreement yet as to when this epoch began. The start might be defined by a historical event, such as
the beginning of the fossil-fueled Industrial Revolution or the first nuclear explosion in 1945. Standard stratigraphic
practice, however, requires a more significant, globally widespread, and abrupt signature, and the
fallout from nuclear weapons testing appears most suitable. The appearance of plutonium 239 (used in post-
1945 above-ground nuclear weapons tests) makes a good marker: This isotope is rare in nature but a significant
component of fallout. It has other features to recommend it as a stable marker in layers of sedimentary rock and
soil, including: long half-life, low solubility, and high particle reactivity. It may be used in conjunction with
other radioactive isotopes, such as americium 241 and carbon 14, to categorize distinct fallout signatures in
sediments and ice caps. On a global scale, the first appearance of plutonium 239 in sedimentary sequences
corresponds to the early 1950s. While plutonium is easily detectable over the entire Earth using modern measurement
techniques, a site to define the Anthropocene (known as a Ògolden spikeÓ) would ideally be located
between 30 and 60 degrees north of the equator, where fallout is maximal, within undisturbed marine or lake
environments
The politics of the digital single market:Culture vs. competition vs. copyright
This paper examines the implications for European music culture of the European Union’s Digital Single Market strategy. It focuses on the regulatory framework being created for the management of copyright policy, and in particular the role played by Collective Management Organisations (or Collecting Societies). One of the many new opportunities created by digitalization has been the music streaming services. These depend on consumers being able to access music wherever they are, but such a system runs counter to the management of rights on a national basis and through collecting organisations who act as monopolies within their own territories. The result has been ‘geo-blocking’. The EU has attempted to resolve this problem in a variety of ways, most recently in a Directive designed to reform the CMOs. In this paper, we document these various efforts, showing them to be motivated by a deep-seated and persisting belief in the capacity of ‘competition’ to resolve problems that, we argue, actually lie elsewhere - in copyright policy itself. The result is that the EU’s intervention fails to address its core concern and threatens the diversity of European music culture by rewarding those who are already commercially successful
Novel Cytokinin Derivatives Do Not Show Negative Effects on Root Growth and Proliferation in Submicromolar Range
BACKGROUND: When applied to a nutrition solution or agar media, the non-substituted aromatic cytokinins caused thickening and shortening of the primary root, had an inhibitory effect on lateral root branching, and even showed some negative effects on development of the aerial part at as low as a 10 nanomolar concentration. Novel analogues of aromatic cytokinins ranking among topolins substituted on N9-atom of adenine by tetrahydropyranyl or 4-chlorobutyl group have been prepared and tested in standardized cytokinin bioassays [1]. Those showing comparable activities with N(6)-benzylaminopurine were further tested in planta. METHODOLOGY/PRINCIPAL FINDINGS: The main aim of the study was to explain molecular mechanism of function of novel cytokinin derivatives on plant development. Precise quantification of cytokinin content and profiling of genes involved in cytokinin metabolism and perception in treated plants revealed several aspects of different action of m-methoxytopolin base and its substituted derivative on plant development. In contrast to standard cytokinins, N9- tetrahydropyranyl derivative of m-topolin and its methoxy-counterpart showed the negative effects on root development only at three orders of magnitude higher concentrations. Moreover, the methoxy-derivative demonstrates a positive effect on lateral root branching and leaf emerging in a nanomolar range of concentrations, in comparison with untreated plants. CONCLUSIONS/SIGNIFICANCE: Tetrahydropyranyl substitution at N9-position of cytokinin purine ring significantly enhances acropetal transport of a given cytokinins. Together with the methoxy-substitution, impedes accumulation of non-active cytokinin glucoside forms in roots, allows gradual release of the active base, and has a significant effect on the distribution and amount of endogenous isoprenoid cytokinins in different plant tissues. The utilization of novel aromatic cytokinin derivatives can distinctively improve expected hormonal effects in plant propagation techniques in the future
Diversity of a cytokinin dehydrogenase gene in wild and cultivated barley
The cytokinin dehydrogenase gene HvCKX2.1 is the regulatory target for the most abundant heterochromatic small RNAs in drought-stressed barley caryopses. We investigated the diversity of HvCKX2.1 in 228 barley landraces and 216 wild accessions and identified 14 haplotypes, five of these with ten or more members, coding for four different protein variants. The third largest haplotype was abundant in wild accessions (51 members), but absent from the landrace collection. Protein structure predictions indicated that the amino acid substitution specific to haplotype 3 could result in a change in the functional properties of the HvCKX2.1 protein. Haplotypes 1–3 have overlapping geographical distributions in the wild population, but the average rainfall amounts at the collection sites for haplotype 3 plants are significantly higher during November to February compared to the equivalent data for plants of haplotypes 1 and 2. We argue that the likelihood that haplotype 3 plants were excluded from landraces by sampling bias that occurred when the first wild barley plants were taken into cultivation is low, and that it is reasonable to suggest that plants with haplotype 3 are absent from the crop because these plants were less suited to the artificial conditions associated with cultivation. Although the cytokinin signalling pathway influences many aspects of plant development, the identified role of HvCKX2.1 in the drought response raises the possibility that the particular aspect of cultivation that mitigated against haplotype 3 relates in some way to water utilization. Our results therefore highlight the possibility that water utilization properties should be looked on as a possible component of the suite of physiological adaptations accompanying the domestication and subsequent evolution of cultivated barley
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