Evidence for a single butyrylcholinesterase gene in individuals carrying the C5 plasma cholinesterase variant (CHE2)

DNA of 3 unrelated individuals carrying the human plasma butyrylcholinesterase C5 variant (CHE2) was isolated from white blood cells. Southern blot patterns of DNA restriction fragments probed with each of the 4 butyrylcholinesterase exons provided evidence that the production of C5 is not directed by a second butyrylcholinesterase gene. This finding supports the suggestion that the C5 variant is a hybrid enzyme resulting from the association of butyrylcholinesterase subunits with a non-cholinesterase protein.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28681/1/0000498.pd

Impuesto sobre el Valor Añadido: tipo aplicable al «alquiler de vehículos con conductor»

El planteamiento del presente trabajo es de orden estrictamente jurídico tributario, tendente a demostrar que el «alquiler de vehículos con conductor» constituye una de las diferentes modalidades del «transporte terrestre de viajeros y sus equipajes» por lo que, y a los efectos del Impuesto sobre el Valor Añadido, el tipo de gravamen a aplicar a los mismos es el reducido y no el general como sostiene la Administración

Observations on the Primary Migration of Oil in the la Luna Source Rocks of the Maracaibo Basin, Venezuela Observations de la migration primaire de l'huile dans les roches mères de la Formation de La Luna dans le bassin de Maracaïbo, Venezuela

In the present work, an integrated approach has been made to understand the primary migration of oil in the organic-rich, oil prone, predominantly carbonate source rocks of the La Luna Formation of the Maracaibo Basin. Geochemical data on source rock extracts and the simulation of oil generation by hydrous-pyrolysis experiments indicate that the primary migration and expulsion of oil began at an early stage of thermal maturity and that the bulk oil expulsion at peak generation could have been as high as 75%. Fluorescence and transmitted light petrography of the source rocks at different maturity levels show the dominant mode of oil expulsion through microfractures. It is interpreted from the geochemical and geological data that the primary migration of oil in the La Luna source rocks took place as a separate oil phase through microfractures caused by the excess fluid pressure due to hydrocarbon generation. The oils expelled from the La Luna source are enriched in saturated hydrocarbons and depleted in resins + asphaltenes compared to the La Luna rock extracts. However the distributions of n-alkanes, in the oils and the rock extracts are very similar, which suggest that fractionation of the n-alkanes did not occur during the primary migration. In the Maracaibo Basin, updip lateral primary migration of oil within the La Luna source system seem to have occurred for a considerable distance. Local internal migration has been observed at a relatively early stage of maturity. Cette étude consiste en une approche intégrée cherchant à comprendre la migration primaire de l'huile dans les roches mères de la Formation de La Luna dans le bassin de Maracaïbo, riches en matière organique, génératrices d'huile et à dominante carbonatée. Les données géochimiques sur des extraits de roches mères et la simulation de genèse d'huile par des expériences de pyrolyse en présence d'eau indiquent que la migration primaire et l'expulsion de l'huile ont commencé à un stade précoce de la maturation thermique et que le volume d'huile expulsée en condition de crête a pu atteindre 75 %. Les analyses de fluorescence et de pétrographie en lumière transmise des roches mères à différents niveaux de maturité montrent que l'expulsion de l'huile se fait principalement à travers les microfissures. On interprète à partir des données géochimiques et géologiques le fait que la migration primaire de l'huile dans les roches mères de La Luna s'est produite comme une migration de l'huile en phase séparée, à travers des microfissures et a été causée par les surpressions de fluides dues à la genèse d'hydrocarbures. Les huiles expulsées des roches mères de La Luna sont enrichies en hydrocarbures saturés et appauvries en résines et asphaltènes, par comparaison avec les extraits de roches de La Luna. Cependant, les répartitions de n-alcanes dans les huiles et dans les extraits de roche sont très semblables, ce qui conduit à suggérer que le fractionnement des n-alcanes ne s'est pas produit pendant la migration primaire. Dans le bassin de Maracaïbo, la migration primaire latérale et ascendante de l'huile dans la Formation de La Luna semble s'être produite sur une distance considérable. Une migration locale interne a été observée à un stade relativement précoce de maturité

Observations on the Primary Migration of Oil in the la Luna Source Rocks of the Maracaibo Basin, Venezuela

In the present work, an integrated approach has been made to understand the primary migration of oil in the organic-rich, oil prone, predominantly carbonate source rocks of the La Luna Formation of the Maracaibo Basin. Geochemical data on source rock extracts and the simulation of oil generation by hydrous-pyrolysis experiments indicate that the primary migration and expulsion of oil began at an early stage of thermal maturity and that the bulk oil expulsion at peak generation could have been as high as 75%. Fluorescence and transmitted light petrography of the source rocks at different maturity levels show the dominant mode of oil expulsion through microfractures. It is interpreted from the geochemical and geological data that the primary migration of oil in the La Luna source rocks took place as a separate oil phase through microfractures caused by the excess fluid pressure due to hydrocarbon generation. The oils expelled from the La Luna source are enriched in saturated hydrocarbons and depleted in resins + asphaltenes compared to the La Luna rock extracts. However the distributions of n-alkanes, in the oils and the rock extracts are very similar, which suggest that fractionation of the n-alkanes did not occur during the primary migration. In the Maracaibo Basin, updip lateral primary migration of oil within the La Luna source system seem to have occurred for a considerable distance. Local internal migration has been observed at a relatively early stage of maturity

Síndrome coronario agudo con ascenso del segmento ST. Protocolo de manejo en una Unidad Móvil de Emergencias.

Nursing early intervention guide in patients with ST-elevation acute coronary syndrome, including epidemiological checking, etiopathogenesis, pathophysiology, pharmaceutical treatment, reperfusion invasive hemodynamic treatment, according to the nursing care planning methodology, in an emergency vehicle.Resumen: Protocolo de actuación inicial en el paciente con síndrome coronario agudo con aumento del ST. Definición, clasificación, etiología, fisiopatología, clínica, electrocardiograma, analítica y proceso de atención de enfermería