Effect of dog breed and body conformation on vertical ground reaction forces, impulses, and stance times

OBJECTIVES: To assess whether fully normalised vertical ground reaction forces and stance times obtained at a trot depend on dog breed or body conformations. METHODS: Peak vertical forces (PVF), vertical impulses (VI), stance times (ST), and ratio of forelimb impulse to total impulse (RVI) of 54 dogs of seven different breeds were normalised to body weight and body size according to the theory of dynamic similarity, and were tested for differences between breeds. Breeds were Borzoi, Bernese Mountain dog, Great Dane, Labrador Retriever, Landseer, Rhodesian Ridgeback, and Rottweiler. Body length ratio (BLR) and body mass index (BMI) were also compared between breeds. RESULTS: Significant differences between breeds were found for the normalised forelimb PVF, VI and ST, and hindlimb PVF. Looking at individual breeds, it was most evident that Borzois had a lower forelimb VI, and a higher hindlimb PVF than the other breeds. This resulted in Borzois having a lower RVI compared to other dogs, indicating a more caudally located centre of gravity. Only a few differences in gait parameters were found between other dog breeds. The BMI was significantly lower in Borzois than in other breeds, but was otherwise not associated with gait parameters. CLINICAL SIGNIFICANCE: Force plate data of dogs of different breeds are not necessarily comparable, even after full normalisation to body weight and body size. Group comparisons should only be made when the groups consist of breeds with similar body conformation

Impact of gastrointestinal side effects on patients’ reported quality of life trajectories after radiotherapy for prostate cancer: Data from the prospective, observational pros-it CNR study

Radiotherapy (RT) represents an important therapeutic option for the treatment of localized prostate cancer. The aim of the current study is to examine trajectories in patients’ reported quality of life (QoL) aspects related to bowel function and bother, considering data from the PROState cancer monitoring in ITaly from the National Research Council (Pros-IT CNR) study, analyzed with growth mixture models. Data for patients who underwent RT, either associated or not associated with androgen deprivation therapy, were considered. QoL outcomes were assessed over a 2-year period from the diagnosis, using the Italian version of the University of California Los Angeles-Prostate Cancer Index (Italian-UCLA-PCI). Three trajectories were identified for the bowel function; having three or more comorbidities and the use of 3D-CRT technique for RT were associated with the worst trajectory (OR = 3.80, 95% CI 2.04–7.08; OR = 2.17, 95% CI 1.22–3.87, respectively). Two trajectories were identified for the bowel bother scores; diabetes and the non-Image guided RT method were associated with being in the worst bowel bother trajectory group (OR = 1.69, 95% CI 1.06–2.67; OR = 2.57, 95% CI 1.70–3.86, respectively). The findings from this study suggest that the absence of comorbidities and the use of intensity modulated RT techniques with image guidance are related with a better tolerance to RT in terms of bowel side effects

Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients: The Pros-IT CNR study

Background: The National Research Council (CNR) prostate cancer monitoring project in Italy (Pros-IT CNR) is an observational, prospective, ongoing, multicentre study aiming to monitor a sample of Italian males diagnosed as new cases of prostate cancer. The present study aims to present data on the quality of life at time prostate cancer is diagnosed. Methods: One thousand seven hundred five patients were enrolled. Quality of life is evaluated at the time cancer was diagnosed and at subsequent assessments via the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and the Short Form Health Survey (SF-12). Results: At diagnosis, lower scores on the physical component of the SF-12 were associated to older ages, obesity and the presence of 3+ moderate/severe comorbidities. Lower scores on the mental component were associated to younger ages, the presence of 3+ moderate/severe comorbidities and a T-score higher than one. Urinary and bowel functions according to UCLA-PCI were generally good. Almost 5% of the sample reported using at least one safety pad daily to control urinary loss; less than 3% reported moderate/severe problems attributable to bowel functions, and sexual function was a moderate/severe problem for 26.7%. Diabetes, 3+ moderate/severe comorbidities, T2 or T3-T4 categories and a Gleason score of eight or more were significantly associated with lower sexual function scores at diagnosis. Conclusions: Data collected by the Pros-IT CNR study have clarified the baseline status of newly diagnosed prostate cancer patients. A comprehensive assessment of quality of life will allow to objectively evaluate outcomes of different profile of care

Modeling environmental bias and computing velocity field from data of Terra Nova Bay GPS network in Antarctica by means of a quasi-observation processing approach

A semi-permanent GPS network of about 30 vertices has been installed at Terra Nova Bay (TNB) near Ross Sea in Antarctica. A permanent GPS station TNB1 based on an Ashtech Z-XII dual frequency P-code GPS receiver with ASH700936D_M Choke Ring Antenna has been mounted on a reinforced concrete pillar built on bedrock since October 1998 and has recorded continuously up to the present. The semi-permanent network has been routinely surveyed every summer using high quality dual frequency GPS receivers with 24 hour sessions at 15 sec rate; data, metadata and solutions will be available to the scientific community at (http://www.geodant.unimore.it). We present the results of a distributed session approach applied to processing GPS data of the TNB GPS network, and based on Gamit/Globk 10.2-3 GPS analysis software. The results are in good agreement with other authors' computations and with many of the theoretical models

Modeling environmental bias and computing velocity field from data of Terra Nova Bay GPS network in Antarctica by means of a quasi-observation processing approach

Abstract A semi-permanent GPS network of about 30 vertices has been installed at Terra Nova Bay (TNB) near Ross Sea in Antarctica. A permanent GPS station TNB1 based on an Ashtech Z-XII dual frequency P-code GPS receiver with ASH700936D_M Choke Ring Antenna has been mounted on a reinforced concrete pillar built on bedrock since October 1998 and has recorded continuously up to the present. The semi-permanent network has been routinely surveyed every summer using high quality dual frequency GPS receivers with 24 hour sessions at 15 sec rate; data, metadata and solutions will be available to the scientific community at (http://www.geodant.unimore.it). We present the results of a distributed session approach applied to processing GPS data of the TNB GPS network, and based on Gamit/Globk 10.2-3 GPS analysis software. The results are in good agreement with other authors' computations and with many of the theoretical models

A three-dimensional electronic report of a venous echo color Doppler of the lower limbs: MEVeC\uae

BACKGROUND: The reports of ultrasound evaluation of lower limb veins are difficult to understand by general practitioners (GPs) and physicians who are not specialized. We developed software for a three-dimensional (3D) electronic report of venous hemodynamic mapping (MEVeC(\uae)) in order to represent lower limb venous vasculature in a 3D way. The aim of the study is to compare the novel 3D report with the standard report.METHODS: Thirty subjects (medical students and GPs) evaluated a standard report and a novel 3D report of the lower limb veins of a prespecified patient. The cases were randomly and blindly taken from an archive of 100 cases. GPs and students answered a questionnaire made up of 13 questions that were structured in order to investigate the readability and comprehension of the two reports. A score ranging from 0 to 10 (0= not understandable; 10= full comprehension) was attributed to each report for each question according to the readability of the venous scheme proposed.RESULTS: The scores from each question of the questionnaire were compared. The 3D report (MEVeC(\uae)) obtained higher scores than those from the evaluation of the standard report (P<0.0001). Each question revealed the superiority of the 3D report (MEVeC(\uae)) as compared with the standard report of the ultrasound evaluation of lower limbs. When dividing the scores according to percentiles, the 3D report (MEVeC(\uae)) still continued to show more readability than the standard report in a statistically significant way (P<0.0001).CONCLUSION: The new 3D report (MEVeC(\uae)) concerning ultrasound evaluation of lower limb veins is more reproducible than the standard report when evaluated by medical physicians not specialized in the evaluation of the vein tree of lower limbs