454 research outputs found

    59th Commencement Address

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    Capitalismo si, pero ¿cual?.

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    La caída del comunismo en Europa del Este es la más grande transformación del mundo económico y político desde la Segunda Guerra Mundial. Nada tan importante pudo imaginarse. Pero esta transformación ha padecido una lectura política simplista y hasta peligrosa. Consecuencia de lo que yo llamo ideología primitiva: es la idea de que existe una muralla muy definida entre los principios del comunismo y las reglas que preceden la economía capitalista de libre empresa.Según esta ideología, ahora los países víctimas del comunismo, caminan hacia el nirvana del capitalismo puro y duro. De los principios del socialismo de Marx y Lenin pasaremos a los formulados por Adam Smith y David Ricardo sobre el capitalismo en su forma más clásica

    A disparada rumo ao capitalismo

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    Desafios ao capitalismo

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    Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

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    This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

    Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

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    Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment
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