360 research outputs found

    Colin Clouts come home again

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    SIGLELD:D45945/83 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

    Addressing the elephant in the room:Learning from CITES CoP17

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    The seventeenth Convention on International Trade in Endangered Species (CITES) conference of the parties (CoP) exhibited a draconian opposition to any trade in ivory. A key component of this opposition was the intergovernmental regime’s consolidation of North–South power differentials through the increased presence and influence of Northern conservation-focused NGOs. Using the example of ivory, this Forum article unpacks this dynamic before advocating for more participatory, decentralized, and polycentric approaches to the global governance of endangered species trade at future CITES CoPs

    ON THE RELATION OF PRODUCTS OF ACTIVATED LYMPHOCYTES TO CELL-MEDIATED CYTOLYSIS

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    Experiments have been designed to test the hypothesis that soluble mediator production and T-cell-mediated cytotoxicity are necessarily related phenomena, and that soluble mediators may be involved in the mechanism of cytolysis. To this end, agents known to inhibit T-cell-mediated lysis in vitro have been studied for their effects on the production of two lymphocyte-derived mediators, lymphotoxin (LT) and migration inhibitory factor (MIF). A clear dissociation between mediator production and cell-mediated cytolysis was found using inhibitors of protein synthesis. Pactamycin and emetine, in doses of 10–7 M to 10–6 M, suppressed production of MIF and LT with only slight effect on killing of mastocytoma cells by immune T cells. On the other hand colchicine and vinblastine inhibited T-cell-mediated cytolysis in a dose-related manner but had no significant effect on either MIF or LT production, A striking dichotomy was also observed after augmentation of intracellular cyclic 3'5' adenosine monophosphate (cAMP) levels with cholera enterotoxin. Increased cAMP levels were associated with abrogation of direct lytic activity, but were without significant effect on MIF or LT production in guinea pigs or mice. These findings indicate that mediator production and direct lymphocyte-mediated cytolysis can be experimentally dissociated and represent independent cell-mediated immune functions

    Unveiling the prehistoric landscape at Stonehenge through multi-receiver EMI

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    YesArchaeological research at Stonehenge (UK) is increasingly aimed at understanding the dynamic of the wider archaeological landscape. Through the application of state-of-the-art geophysical techniques, unprecedented insight is being gathered into the buried archaeological features of the area. However, applied survey techniques have rarely targeted natural soil variation, and the detailed knowledge of the palaeotopography is consequently less complete. In addition, metallic topsoil debris, scattered over different parts of the Stonehenge landscape, often impacts the interpretation of geophysical datasets. The research presented here demonstrates how a single multi-receiver electromagnetic induction (EMI) survey, conducted over a 22 ha area within the Stonehenge landscape, offers detailed insight into natural and anthropogenic soil variation at Stonehenge. The soil variations that were detected through recording the electrical and magnetic soil variability, shed light on the genesis of the landscape, and allow for a better definition of potential palaeoenvironmental and archaeological sampling locations. Based on the multi-layered dataset, a procedure was developed to remove the influence of topsoil metal from the survey data, which enabled a more straightforward identification of the detected archaeology. The results provide a robust basis for further geoarchaeological research, while potential to differentiate between modern soil disturbances and the underlying sub-surface variations can help in solving conservation and management issues. Through expanding this approach over the wider area, we aim at a fuller understanding of the human–landscape interactions that have shaped the Stonehenge landscape

    EXPLORING DIFFERENCES IN ELECTROMYOGRAPHY AND GROUND REACTION FORCES BETWEEN FRONT AND BACK SQUATS BEFORE AND AFTER A FATIGUING PROTOCOL

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    Limited research has been conducted to explore differences in biomechanical and physiological demands of the front and back squat, especially in response to fatigue where technique may be altered. This study investigated differences in electromyography and ground reaction forces during a 3-repetition maximum back and front squat before and after a fatiguing protocol in 30 males. Mean and peak activation of the semitendinosus was greater in the back squat than the front squat (p \u3c 0.05). There were no differences in quadricep activation between back and front squats. There were no differences in electromyography as a result of fatigue, however, force production decreased for back squats following fatigue (p \u3c 0.01). This research disputed the notion that front squats have a greater quadricep focus, however lends support to the hypothesis that quadricep activation equal to the back squat can be achieved with lighter absolute load in a front squat. The finding of lower ground reaction forces for the back squat following the fatiguing protocol in addition to no differences in electromyography between front and back squats indicates greater effects of the fatiguing protocol on back squat performance
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