On the dbar/ubar Asymmetry and Parton Distributions

We discuss the impact of different measurements of the dbar/ubar asymmetry in the extraction of parameterizations of parton distribution functions.Comment: Contributed paper to LP01, 13 pages, 4 figure

Dynamic longitudinal discriminant analysis using multiple longitudinal markers of different types

There is an emerging need in clinical research to accurately predict patients disease status and disease progression by optimally integrating multivariate clinical information. Clinical data is often collected over time for multiple biomarkers of different types (e.g. continuous, binary, counts). In this paper, we present a flexible and dynamic (time-dependent) discriminant analysis approach in which multiple biomarkers of various types are jointly modelled for classification purposes by the multivariate generalized linear mixed model. We propose a mixture of normal distributions for the random effects to allow additional flexibility when modelling the complex correlation between longitudinal biomarkers and to robustify the model and the classification procedure against misspecification of the random effects distribution. These longitudinal models are subsequently used in a multivariate time-dependent discriminant scheme to predict, at any time point, the probability of belonging to a particular risk group. The methodology is illustrated using clinical data from patients with epilepsy, where the aim is to identify patients who will not achieve remission of seizures within a 5-year follow up period

Extending invariant complex structures

We study the problem of extending a complex structure to a given Lie algebra g, which is firstly defined on an ideal h of g. We consider the next situations: h is either complex or it is totally real. The next question is to equip g with an additional structure, such as a (non)-definite metric or a symplectic structure and to ask either h is non-degenerate, isotropic, etc. with respect to this structure, by imposing a compatibility assumption. We show that this implies certain constraints on the algebraic structure of g. Constructive examples illustrating this situation are shown, in particular computations in dimension six are given.Comment: 22 pages, plus an Addendu

Development and Dissemination of a New Multidisciplinary Undergraduate Curriculum in Digital Forensics

The Information Trust Institute (ITI) at the University of Illinois at Urbana-Champaign is developing an entirely new multidisciplinary undergraduate curriculum on the topic of digital forensics, and this paper presents the findings of the development process, including initial results and evaluation of a pilot offering of the coursework to students. The curriculum consists of a four-course sequence, including introductory and advanced lecture courses with parallel laboratory courses, followed by an advanced course. The content has been designed to reflect both the emerging national standards and the strong multidisciplinary character of the profession of digital forensics, and includes modules developed collaboratively by faculty experts in multiple fields of computer science, law, psychology, social sciences, and accountancy. A preliminary plan for the introductory course was presented to a workshop of digital forensics experts in May 2013 and received their strong approval. Pilot versions of the introductory and introductory lab courses were taught to a mixture of computer science and law students at the University of Illinois in the fall of 2013, and were very positively received by the students, who made it clear that they appreciated the multidisciplinary approach. The curriculum, which is designed to obviate the need for expensive labs or team-teaching by specialized faculty, will be made available to other colleges and universities in order to improve the content and quality of existing digital forensics programs, to inspire and greatly facilitate the creation of new programs, and, ultimately, to increase the number of educated practitioners. The developed resources can be used as the basis for future academic programs, distance learning, and multidisciplinary, multi-institutional programs that meet evolving digital forensics educational standards. Much of the material, including a virtual laboratory, will be provided on-line. Introductory course materials will be distributed to other institutions beginning in the summer of 2014; advanced course materials should be available for distribution in 2015. Related outreach activities have been undertaken and will be continued. Keywords: Digital forensics, Computer forensics, Curriculum development, Curriculum standards, Education standards, Training standards, Undergraduate education, Interdisciplinary studie

Climate change and the kidney

The worldwide increase in temperature has resulted in a marked increase in heat waves (heat extremes) that carries a markedly increased risk for morbidity and mortality. The kidney has a unique role not only in protecting the host from heat and dehydration but also is an important site of heat-associated disease. Here we review the potential impact of global warming and heat extremes on kidney diseases. High temperatures can result in increased core temperatures, dehydration, and blood hyperosmolality. Heatstroke (both clinical and subclinical whole-body hyperthermia) may have a major role in causing both acute kidney disease, leading to increased risk of acute kidney injury from rhabdomyolysis, or heat-induced inflammatory injury to the kidney. Recurrent heat and dehydration can result in chronic kidney disease (CKD) in animals and theoretically plays a role in epidemics of CKD developing in hot regions of the world where workers are exposed to extreme heat. Heat stress and dehydration also has a role in kidney stone formation, and poor hydration habits may increase the risk for recurrent urinary tract infections. The resultant social and economic consequences include disability and loss of productivity and employment. Given the rise in world temperatures, there is a major need to better understand how heat stress can induce kidney disease, how best to provide adequate hydration, and ways to reduce the negative effects of chronic heat exposure.Published versio

Municipal Utilities: An Overview Of Rate Models, Sustainability And The Effects On Affordability

Municipalities are faced with escalating costs, harder to find resources, and increasing regulatory restrictions in an effort to maintain public utilities.  To complicate this situation, communities must address a growing number of individuals who are unable to pay their utility bill.  This study is a review of several water utilities in Florida to determine how typical municipal utilities approaches affordability. Factors affecting utilities such as sustainability, rate models, and regulations are examined to the present methodology for an average municipality in addressing the increasing important issue of affordability.  This research is a continuation of a longitudinal study to determine how municipalities address increasing costs to maintain their utility while considering those in the community who are less fortunate and cannot continue to absorb the higher costs of water and wastewater

Cost-effectiveness and resource implications of aggressive action on tuberculosis in China, India, and South Africa: a combined analysis of nine models

Background The post-2015 End TB Strategy sets global targets of reducing tuberculosis incidence by 50% and mortality by 75% by 2025. We aimed to assess resource requirements and cost-effectiveness of strategies to achieve these targets in China, India, and South Africa. Methods We examined intervention scenarios developed in consultation with country stakeholders, which scaled up existing interventions to high but feasible coverage by 2025. Nine independent modelling groups collaborated to estimate policy outcomes, and we estimated the cost of each scenario by synthesising service use estimates, empirical cost data, and expert opinion on implementation strategies. We estimated health effects (ie, disability-adjusted life-years averted) and resource implications for 2016–35, including patient-incurred costs. To assess resource requirements and cost-effectiveness, we compared scenarios with a base case representing continued current practice. Findings Incremental tuberculosis service costs differed by scenario and country, and in some cases they more than doubled existing funding needs. In general, expansion of tuberculosis services substantially reduced patient-incurred costs and, in India and China, produced net cost savings for most interventions under a societal perspective. In all three countries, expansion of access to care produced substantial health gains. Compared with current practice and conventional cost-effectiveness thresholds, most intervention approaches seemed highly cost-effective. Interpretation Expansion of tuberculosis services seems cost-effective for high-burden countries and could generate substantial health and economic benefits for patients, although substantial new funding would be required. Further work to determine the optimal intervention mix for each country is necessary

Neutrino Masses and Lepton Flavour Violation in Thick Brane Scenarios

We address the issue of lepton flavour violation and neutrino masses in the ``fat-brane'' paradigm, where flavour changing processes are suppressed by localising different fermion field wave-functions at different positions (in the extra dimensions) in a thick brane. We study the consequences of suppressing lepton number violating charged lepton decays within this scenario for lepton masses and mixing angles. In particular, we find that charged lepton mass matrices are constrained to be quasi-diagonal. We further consider whether the same paradigm can be used to naturally explain small Dirac neutrino masses by considering the existence of three right-handed neutrinos in the brane, and discuss the requirements to obtain phenomenologically viable neutrino masses and mixing angles. Finally, we examine models where neutrinos obtain a small Majorana mass by breaking lepton number in a far away brane and show that, if the fat-brane paradigm is the solution to the absence of lepton number violating charged lepton decays, such models predict, in the absence of flavour symmetries, that charged lepton flavour violation will be observed in the next round of rare muon/tau decay experiments.Comment: 33 pages, 9 eps figure