Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet

Seedling root traits impact plant establishment under challenging environments. Pearl millet is one of the most heat and drought tolerant cereal crops that provides a vital food source across the sub-Saharan Sahel region. Pearl millet’s early root system features a single fast-growing primary root which we hypothesize is an adaptation to the Sahelian climate. Using crop modeling, we demonstrate that early drought stress is an important constraint in agrosystems in the Sahel where pearl millet was domesticated. Furthermore, we show that increased pearl millet primary root growth is correlated with increased early water stress tolerance in field conditions. Genetics including genome-wide association study and quantitative trait loci (QTL) approaches identify genomic regions controlling this key root trait. Combining gene expression data, re-sequencing and re-annotation of one of these genomic regions identified a glutaredoxin-encoding gene PgGRXC9 as the candidate stress resilience root growth regulator. Functional characterization of its closest Arabidopsis homolog AtROXY19 revealed a novel role for this glutaredoxin (GRX) gene clade in regulating cell elongation. In summary, our study suggests a conserved function for GRX genes in conferring root cell elongation and enhancing resilience of pearl millet to its Sahelian environment

Intérêt des CVIMAR dans le collage des brackets en céramique

Le collage en orthodontie se heurte aujourd'hui à ses effets délétères. Le mordançage acide, responsable d'une perte pure et simple d'émail, la persistance des resins tags après dépose, et les fractures récurrentes à l'interface émail-adhésif ne permettent pas de restituer la dent telle que le patient nous l'a confiée. L'utilisation des Ciments verres ionomères modifiés par adjonction de résine pourrait apporter une solution à ces inconvénients. Leur adhésion chimique intrinsèque au substrat amélaire, doublée de propriétés mécaniques améliorées, laissent espérer une adhésion équivalente pour une restitution ad integrum de l'émail. A l'heure d'une recrudescence des consultations adultes dans les services d'orthodontie, la demande en traitements invisibles explose. Les brackets céramiques à rétention mécanique cherchent à répondre à cette demande, autant qu'à éviter les travers de la rétention chimique par silanisation, responsable de trop fréquents dégâts amélaires. LA question posée par l'étude réalisée dans cette thèse est la suivante: les CVIMAR constituent-ils une alternative intéressante aux composites de collage traditionnels, dans le collage des brackets en céramique à rétention mécanique? Le CVIMAR peut-il supporter les contraintes imposées par les microclavetage des bases? Des questions subsidiaires, telles que le collage aux dents déciduales bovines, sont aussi abordées.RENNES1-BU Santé (352382103) / SudocSudocFranceF

Antithrombotic therapies for neurointerventional surgery: a 2021 French comprehensive national survey

International audienceBackground Neurointerventionists lack guidelines for the use of antithrombotic therapies in their clinical practice; consequently, there is likely to be significant heterogeneity in antithrombotic use between centers. Through a nationwide survey, we aimed to obtain an exhaustive cross-sectional overview of antithrombotic use in neurointerventional procedures in France. Methods In April 2021, French neurointerventional surgery centers were invited to participate in a nationwide 51-question survey disseminated through an active trainee-led research collaborative network (the JENI-RC). Results All 40 centers answered the survey. Fifty-one percent of centers reported using ticagrelor and 43% used clopidogrel as premedication before intracranial stenting. For flow diversion treatment, dual antiplatelet therapy was maintained for 3 or 6 months in 39% and 53% of centers, respectively, and aspirin was prescribed for 12 months or more than 12 months in 63% and 26% of centers, respectively. For unruptured aneurysms, the most common heparin bolus dose was 50 IU/kg (59%), and only 35% of centers monitored heparin activity for dose adjustment. Tirofiban was used in 64% of centers to treat thromboembolic complications. Fifteen percent of these comprehensive stroke centers reported using tenecteplase to treat acute ischemic strokes. Cangrelor appeared as an emergent drug in specific indications. Conclusion This nationwide survey highlights the important heterogeneity in clinical practices across centers. There is a pressing need for trials and guidelines to further evaluate and harmonize antithrombotic regimens in the neurointerventional field

Vasculitis associated with myelodysplastic syndrome and chronic myelomonocytic leukemia: French multicenter case-control study

International audienc