983 research outputs found
What a difference a term makes:the effect of educational attainment on marital outcomes in the UK
Abstract In the past, students in England and Wales born within the first 5 monthsof the academic year could leave school one term earlier than those born later inthe year. Focusing on women, those who were required to stay on an extra termmore frequently hold some academic qualification. Using having been required tostay on as an exogenous factor affecting academic attainment, we find that holding alow-level academic qualification has no effect on the probability of being currentlymarried for women aged 25 or above, but increases the probability of the husbandholding some academic qualification and being economically active.33 Halama
Hysteresis phenomenon in turbulent convection
Coherent large-scale circulations of turbulent thermal convection in air have
been studied experimentally in a rectangular box heated from below and cooled
from above using Particle Image Velocimetry. The hysteresis phenomenon in
turbulent convection was found by varying the temperature difference between
the bottom and the top walls of the chamber (the Rayleigh number was changed
within the range of ). The hysteresis loop comprises the one-cell
and two-cells flow patterns while the aspect ratio is kept constant (). We found that the change of the sign of the degree of the anisotropy of
turbulence was accompanied by the change of the flow pattern. The developed
theory of coherent structures in turbulent convection (Elperin et al. 2002;
2005) is in agreement with the experimental observations. The observed coherent
structures are superimposed on a small-scale turbulent convection. The
redistribution of the turbulent heat flux plays a crucial role in the formation
of coherent large-scale circulations in turbulent convection.Comment: 10 pages, 9 figures, REVTEX4, Experiments in Fluids, 2006, in pres
Terahertz underdamped vibrational motion governs protein-ligand binding in solution
Low-frequency collective vibrational modes in proteins have been proposed as being responsible for efficiently directing biochemical reactions and biological energy transport. However, evidence of the existence of delocalized vibrational modes is scarce and proof of their involvement in biological function absent. Here we apply extremely sensitive femtosecond optical Kerr-effect spectroscopy to study the depolarized Raman spectra of lysozyme and its complex with the inhibitor triacetylchitotriose in solution. Underdamped delocalized vibrational modes in the terahertz frequency domain are identified and shown to blue-shift and strengthen upon inhibitor binding. This demonstrates that the ligand-binding coordinate in proteins is underdamped and not simply solvent-controlled as previously assumed. The presence of such underdamped delocalized modes in proteins may have significant implications for the understanding of the efficiency of ligand binding and protein–molecule interactions, and has wider implications for biochemical reactivity and biological function
Linear-T resistivity and change in Fermi surface at the pseudogap critical point of a high-Tc superconductor
A fundamental question of high-temperature superconductors is the nature of
the pseudogap phase which lies between the Mott insulator at zero doping and
the Fermi liquid at high doping p. Here we report on the behaviour of charge
carriers near the zero-temperature onset of that phase, namely at the critical
doping p* where the pseudogap temperature T* goes to zero, accessed by
investigating a material in which superconductivity can be fully suppressed by
a steady magnetic field. Just below p*, the normal-state resistivity and Hall
coefficient of La1.6-xNd0.4SrxCuO4 are found to rise simultaneously as the
temperature drops below T*, revealing a change in the Fermi surface with a
large associated drop in conductivity. At p*, the resistivity shows a linear
temperature dependence as T goes to zero, a typical signature of a quantum
critical point. These findings impose new constraints on the mechanisms
responsible for inelastic scattering and Fermi surface transformation in
theories of the pseudogap phase.Comment: 24 pages, 6 figures. Published in Nature Physics. Online at
http://www.nature.com/nphys/journal/vaop/ncurrent/full/nphys1109.htm
Energy- and flux-budget (EFB) turbulence closure model for the stably stratified flows. Part I: Steady-state, homogeneous regimes
We propose a new turbulence closure model based on the budget equations for
the key second moments: turbulent kinetic and potential energies: TKE and TPE
(comprising the turbulent total energy: TTE = TKE + TPE) and vertical turbulent
fluxes of momentum and buoyancy (proportional to potential temperature).
Besides the concept of TTE, we take into account the non-gradient correction to
the traditional buoyancy flux formulation. The proposed model grants the
existence of turbulence at any gradient Richardson number, Ri. Instead of its
critical value separating - as usually assumed - the turbulent and the laminar
regimes, it reveals a transition interval, 0.1< Ri <1, which separates two
regimes of essentially different nature but both turbulent: strong turbulence
at Ri<<1; and weak turbulence, capable of transporting momentum but much less
efficient in transporting heat, at Ri>1. Predictions from this model are
consistent with available data from atmospheric and lab experiments, direct
numerical simulation (DNS) and large-eddy simulation (LES).Comment: 40 pages, 6 figures, Boundary-layer Meteorology, resubmitted, revised
versio
Determination of Interleukin-6 and Tumor Necrosis Factor-alpha concentrations in Iranian-Khorasanian patients with preeclampsia
BACKGROUND: Our objective was to determine the role of Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-alpha), markers of immune activation and endothelial dysfunction, in patients with preeclampsia. METHODS: Twenty four women with preeclampsia and eighteen antepartum normotensive pregnant women were recruited as controls. Serum levels of IL-6 and TNF-alpha were measured by enzyme-linked immunosorbent assay. We used independent-samples t test to assess the differences in the concentration of cytokines in preeclamptic patients and control subjects. RESULTS: IL-6 levels [mean (S.D.)] were significantly higher in preeclamptic women [5.8 (4.85) pg/ml] compared to normal pregnant women [3.01 (2.45) pg/ml] (p = 0.02). There was no significant change in concentration of TNF-alpha in preeclamptic women [53.8 (30.0) pg/ml] compared to normal pregnant women [51.9 (33.8) pg/ml] (p > 0.1). CONCLUSION: The results of this study show that IL-6 as a pro-inflammatory cytokine is present in higher concentration in women with preeclampsia. The study was undertaken in women with established preeclampsia and it is not possible to determine whether the increased concentration of IL-6 is a cause or consequence of the disease. Furthermore, these findings suggest that serum TNF-alpha level is not associated with preeclampsia
Potential health impacts of heavy metals on HIV-infected population in USA.
Noninfectious comorbidities such as cardiovascular diseases have become increasingly prevalent and occur earlier in life in persons with HIV infection. Despite the emerging body of literature linking environmental exposures to chronic disease outcomes in the general population, the impacts of environmental exposures have received little attention in HIV-infected population. The aim of this study is to investigate whether individuals living with HIV have elevated prevalence of heavy metals compared to non-HIV infected individuals in United States. We used the National Health and Nutrition Examination Survey (NHANES) 2003-2010 to compare exposures to heavy metals including cadmium, lead, and total mercury in HIV infected and non-HIV infected subjects. In this cross-sectional study, we found that HIV-infected individuals had higher concentrations of all heavy metals than the non-HIV infected group. In a multivariate linear regression model, HIV status was significantly associated with increased blood cadmium (p=0.03) after adjusting for age, sex, race, education, poverty income ratio, and smoking. However, HIV status was not statistically associated with lead or mercury levels after adjusting for the same covariates. Our findings suggest that HIV-infected patients might be significantly more exposed to cadmium compared to non-HIV infected individuals which could contribute to higher prevalence of chronic diseases among HIV-infected subjects. Further research is warranted to identify sources of exposure and to understand more about specific health outcomes
Profiling microRNAs in individuals at risk of progression to rheumatoid arthritis
Background: Individuals at risk of rheumatoid arthritis (RA) demonstrate systemic autoimmunity in the form of anti-citrullinated peptide antibodies (ACPA). MicroRNAs (miRNAs) are implicated in established RA. This study aimed to (1) compare miRNA expression between healthy individuals and those at risk of and those that develop RA, (2) evaluate the change in expression of miRNA from "at-risk" to early RA and (3) explore whether these miRNAs could inform a signature predictive of progression from "at-risk" to RA. Methods: We performed global profiling of 754 miRNAs per patient on a matched serum sample cohort of 12 anti-cyclic citrullinated peptide (CCP) + "at-risk" individuals that progressed to RA. Each individual had a serum sample from baseline and at time of detection of synovitis, forming the matched element. Healthy controls were also studied. miRNAs with a fold difference/fold change of four in expression level met our primary criterion for selection as candidate miRNAs. Validation of the miRNAs of interest was conducted using custom miRNA array cards on matched samples (baseline and follow up) in 24 CCP+ individuals; 12 RA progressors and 12 RA non-progressors. Results: We report on the first study to use matched serum samples and a comprehensive miRNA array approach to identify in particular, three miRNAs (miR-22, miR-486-3p, and miR-382) associated with progression from systemic autoimmunity to RA inflammation. MiR-22 demonstrated significant fold difference between progressors and non-progressors indicating a potential biomarker role for at-risk individuals. Conclusions: This first study using a cohort with matched serum samples provides important mechanistic insights in the transition from systemic autoimmunity to inflammatory disease for future investigation, and with further evaluation, might also serve as a predictive biomarker
Higher-order multipole amplitudes in charmonium radiative transitions
Using 24 million decays in CLEO-c, we have searched
for higher multipole admixtures in electric-dipole-dominated radiative
transitions in charmonia. We find good agreement between our data and
theoretical predictions for magnetic quadrupole (M2) amplitudes in the
transitions and ,
in striking contrast to some previous measurements. Let and
denote the normalized M2 amplitudes in the respective aforementioned decays,
where the superscript refers to the angular momentum of the . By
performing unbinned maximum likelihood fits to full five-parameter angular
distributions, we determine the ratios and , where
the theoretical predictions are independent of the charmed quark magnetic
moment and are and .Comment: 32 pages, 7 figures, acceptance updat
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