Effect of oxidative stress on ABC transporters: contribution to epilepsy pharmacoresistance

Epilepsy is a neurological disorder affecting around 1%-2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression of ATP-binding cassette transporters is considered one of the major reasons for pharmacoresistance. In this review, we have summarized the regulation of ABC transporters in response to oxidative stress due to disease and antiepileptic drugs. Further, ketogenic diet and antioxidants were examined for their role in pharmacoresistance. The understanding of signalling pathways and mechanism involved may help in identifying potential therapeutic targets and improving drug response

Who fakes support for the military? Experimental evidence from Tunisia

Surveys around the world report exceptionally high levels of support for the military. This is particularly relevant for countries in transition from authoritarian rule to democracy, where militaries can play a vital role for democratic consolidation or autocratic backsliding. Given the sensitive nature of the issue, we suspect that figures indicating strong support for the military are at least partly driven by sensitivity bias. We explore this possibility through list experiments in two nationally representative surveys in Tunisia. We find that misreporting of support for the military in Tunisia is substantial, with respondents overreporting positive attitudes by 40–50 percentage points. Moreover, misreporting is not random, but instead varies systematically by incumbency, with supporters of governing parties misreporting support for the military to a significantly higher degree than opposition supporters or non-voters. Our results suggest that public opinion researchers should be wary of using direct questions to measure support for the military

NUMERICAL TRANSIENT HEAT TRANSFER ANALYSIS OF REACTOR FOR MAGNESIUM BASED ALLOY FOR HYDROGEN STORAGE APPLICATION

Metal hydrides are potential hydrogen storage media. They release hydrogen at moderate temperatures and pressures. Magnesium hydride is a promising approach for stationary power system application, due to high hydrogen storage capacity by weight. Magnesium hydride based reactor design is more complex due to high thermal energy release and absorption during hydriding reaction and dehydriding reaction, respectively. In this study, results of a numerical modeling study are presented for a 1.5 kg Magnesium alloy based hydriding reactor. Temperature profile in the reactor is computed by FEM analysis using ANSYS software for hydriding and dehydriding reaction. FEM analysis indicates that the reactor temperature is raised from 200 C to 422 ºC in 20 minutes during the hydriding process. Hence, a “cooling system” is required for maintaining temperature during the hydriding process. During the dehydriding process, maximum temperature drop occurs from 350 C to 189 ºC in 20 minutes. Therefore, an external heat source of 2 kW is required for maintaining the temperature during dehydriding. Details are presented

Mineralogy of soils of major geomorphic units of north-eastern Haryana, India

The study was carried to determine the mineralogy of soils of different geomorphic units for providing the more detailed information needed to improve agricultural production in north-eastern part of Haryana. The soils of the study area were slightly acidic to strongly alkaline in reaction (6-9.4). The cation exchange capacity and electrical conductivity varied from 3.10-26.80 cmol (+) kg-1 and 0.16-1.20 dSm-1, respectively. In general, the soils were siliceous in nature with SiO2 ranging from 68.60 to 87.90 percent. The soil samples from surface and subsurface diagnostic horizons were studied through X-ray diffraction. In fine sand, quartz was the dominant mineral followed by feldspars, muscovite, hornblende, tourmaline, zircon, biotite, iron ores and sphene. In silt fraction, quartz was the dominant mineral followed by mica, feldspars, chlorite, kaolinite, interstratified and traces of smectite and vermiculite. Semi-quantitative estimation of clay fraction indicated that illite was the single dominant mineral in the clay fraction of these pedons, however, its quantity was less in alluvial plains (28-30 %) compared to Shiwalik hills (36-49 %). Next to illite, a high amount of smectite (14-20 %) and vermiculite (11-17 %) were observed in clays of alluvial plains of Ghaggar (recent and old) whereas in Shiwalik hills (top and valley) these minerals were detected in small amount (6-11 %). Fairly good amount of kaolinite (10-17 %) and small amount of chlorite (4-11 %) were uniformly distributed in soil clays irrespective of geomorphic units showing their detrital origin. Medium intensity broad peaks in higher range diffractograms (14-24 AËš) indicated the presence of regular and irregular interstratified minerals in old alluvial plains of Ghaggar

Communication in the Gig Economy: Buying and Selling in Online Freelance Marketplaces

The proliferating gig economy relies on online freelance marketplaces, which support relatively anonymous interactions by text-based messages. Informational asymmetries thus arise that can lead to exchange uncertainties between buyers and freelancers. Conventional marketing thought recommends reducing such uncertainty. However, uncertainty reduction and uncertainty management theories indicate that buyers and freelancers might benefit more from balancing, rather than reducing, uncertainty, such as by strategically adhering to or deviating from common principles. With dyadic analyses of calls for bids and bids from a leading online freelance marketplace, this study reveals that buyers attract more bids from freelancers when they provide moderate degrees of task information and concreteness, avoid sharing personal information, and limit the affective intensity of their communication. Freelancers’ bid success and price premiums increase when they mimic the degree of task information and affective intensity exhibited by buyers. However, mimicking a lack of personal information and concreteness reduces freelancers’ success, so freelancers should always be more concrete and offer more personal information than buyers do. These contingent perspectives offer insights into buyer–seller communication in two-sided online marketplaces; they clarify that despite, or sometimes due to, communication uncertainty, both sides can achieve success in the online gig economy

Unveiling What is Written in The Stars: Analyzing Explicit, Implicit, and Discourse Patterns of Sentiment in Social Media

Deciphering consumers' sentiment expressions from big data (e.g., online reviews) has become a managerial priority to monitor product and service evaluations. However, sentiment analysis, the process of automatically distilling sentiment from text, provides little insight regarding the language granularities beyond the use of positive and negative words. Drawing on speech act theory, this study provides a fine-grained analysis of the implicit and explicit language used by consumers to express sentiment in text. An empirical text-mining study using more than 45,000 consumer reviews demonstrates the differential impacts of activation levels (e.g., tentative language), implicit sentiment expressions (e.g., commissive language), and discourse patterns (e.g., incoherence) on overall consumer sentiment (i.e., star ratings). In two follow-up studies, we demonstrate that these speech act features also influence the readers' behavior and are generalizable to other social media contexts, such as Twitter and Facebook. We contribute to research on consumer sentiment analysis by offering a more nuanced understanding of consumer sentiments and their implications

The emotional review–reward effect: how do reviews increase impulsivity?

A growing reliance on customer reviews prompts firms to develop strategies to encourage customers to post online reviews of their products. However, little research investigates the behavioral consequences of writing a review. The act of sharing personal opinions through reviews is a rewarding experience and makes customers feel socially connected. With an application of reverse alliesthesia theory, the current study predicts that such rewarding experiences drive online reviewers to seek other rewards, such as impulsive buying. Three lab-based and two field studies demonstrate such an emotional review–reward effect: sharing emotional inf ormation in the public realm of customer reviews, rather than forming similar opinions privately, drives participants to make more impulsive buying decisions

Inverse problem of photoelastic fringe mapping using neural networks

This paper presents an enhanced technique for inverse analysis of photoelastic fringes using neural networks to determine the applied load. The technique may be useful in whole-field analysis of photoelastic images obtained due to external loading, which may find application in a variety of specialized areas including robotics and biomedical engineering. The presented technique is easy to implement, does not require much computation and can cope well within slight experimental variations. The technique requires image acquisition, filtering and data extraction, which is then fed to the neural network to provide load as output. This technique can be efficiently implemented for determining the applied load in applications where repeated loading is one of the main considerations. The results presented in this paper demonstrate the novelty of this technique to solve the inverse problem from direct image data. It has been shown that the presented technique offers better result for the inverse photoelastic problems than previously published works