583 research outputs found
Linearity of a silicon carbide photodiode in the deep-UV spectral region: implications on Doppler broadening thermometry
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Hypoimmunogenic Derivatives of Induced Pluripotent Stem Cells Evade Immune Rejection in Fully Immunocompetent Allogeneic Recipients
Ghost-gluon coupling, power corrections and from twisted-mass lattice QCD at Nf=2
We present results concerning the non-perturbative evaluation of the
ghost-gluon running QCD coupling constant from twisted-mass lattice
calculations. A novel method for calibrating the lattice spacing, independent
of the string tension and hadron spectrum is presented with results in
agreement with previous estimates. The value of is
computed from the running of the QCD coupling only after extrapolating to zero
dynamical quark mass and after removing a non-perturbative OPE contribution
that is assumed to be dominated by the dimension-two \VEV{A^2} gluon
condensate. The effect due to the dynamical quark mass in the determination of
\Lams is discussed.Comment: 33 pages, 6 fig
First Report on the Benthic Invertebrate Community Associated With a Bronze Naval Ram From the First Punic War: A Proxy of Marine Biodiversity
Historical traces of organisms on the seafloor, such as shells and tubes, constitute the
ecological memory of ancient benthic assemblages and serve as an important resource
for understanding the assembly of modern communities. Archeological shipwrecks are
particularly interesting submerged substrata for both their archeological and biological
implications. For the first time, we studied the species composition and life-history
traits of dominant organisms in the benthic assemblage on a bronze Carthaginian
naval ram, which sank more than two thousand years ago in the Southern Tyrrhenian
Sea. By comparing the species composition of the ram assemblage with those of
the surrounding habitats, we inferred possible colonization patterns for the ram and
discussed the informative role of the shipwreck as a proxy of marine biodiversity.
The ram assemblage was rich in species, including both sessile (bryozoans, serpulid
polychaetes, and few bivalves) and motile (gastropods) species. Sexual reproduction
with free-spawning fertilization and long-duration larvae characterized most species.
The long submersion time of the ram, together with the reproductive strategies, growth
forms, and motility of the dominant species were key factors shaping the community
of the ram. The ram itself offers an archeological artifact of inestimable value, but
our analysis revealed it to be an effective collector of fauna from the surrounding
seabed. The ram community hosted species from a range of nearby natural habitats
(mostly coralligenous, detritic bottoms, and zoosteracean meadows) and thus served
as a proxy for marine biodiversity on the surrounding seabed. We conclude that the
presence of many species on the ram that commonly occur in adjacent habitats of great
environmental value was informative and highlight the important marine biodiversity in
the area of the Aegadian archipelago
Inseticidas no controle da transmissão de begomovírus ao tomateiro.
O objetivo deste trabalho foi avaliar a interferencia dos inseticidas na transmissão de begomovírus ao tomateiro.Resumo 1321
Sulodexide counteracts endothelial dysfunction induced by metabolic or non-metabolic stresses through activation of the autophagic program
OBJECTIVE: Endothelial dysfunction (ED) predisposes to venous thrombosis (VT) and post-thrombotic syndrome (PTS), a long-term VT-related complication. Sulodexide (SDX) is a highly purified glycosaminoglycan with antithrombotic, pro-fibrinolytic and anti-inflammatory activity used in the treatment of chronic venous disease (CVD), including patients with PTS. SDX has recently obtained clinical evidence in the “extension therapy” after initial-standard anticoagulant treatment for the secondary prevention of recurrent deep vein thrombosis (DVT). Herein, we investigated how SDX counteracts ED. MATERIALS AND METHODS: Human umbilical vein endothelial cells (HUVEC) were used. Metabolic and non metabolic-induced ED was induced by treating with methylglyoxal (MGO) or irradiation (IR), respectively. Bafilomycin A1 was used to inhibit autophagy. The production of reactive oxygen species (ROS), tetrazolium bromide (MTT) assay for cell viability, terminal de-oxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay for cell apoptosis, Real-time PCR and Western blot analysis for gene and protein expression were used. RESULTS: SDX protected HUVEC from MGO- or IR-induced apoptosis by counteracting the activation of the intrinsic and extrinsic caspase cascades. The cytoprotective effects of SDX resulted from a reduction in a) ROS production, b) neo-synthesis and release of pro-inflammatory cytokines (TNFα, IL1, IL6, IL8), c) DNA damage induced by MGO or IR. These effects were reduced when autophagy was inhibited. CONCLUSIONS: Data herein collected indicate the ability of SDX to counteract ED induced by metabolic or non-metabolic stresses by involving the intracellular autophagy pathway. Our experience significantly increases the knowledge of the mechanisms of action of SDX against ED and supports the use of SDX in the treatment of CVD, PTS and in the secondary prevention of recurrent DVT
Eficiência de produtos alternativos sobre Tetranychus urticae e sua compatibilidade com Neoseiulus californicus em morangueiro.
Eficiência de produtos alternativos sobre Tetranychus urticae e sua compatibilidade com Neoseiulus californicus em morangueiro.
Resumo 136
Oral platelet gel supernatant plus supportive medical treatment versus supportive medical treatment in the management of radiation-induced oral mucositis: a matched explorative active control trial by propensity analysis
OBJECTIVES:: In this active control trial, the rate of radio-induced WHO grade 3/4 oral mucositis and the change in quality of life, assessed by OMWQ-HN, were measured in subjects with head and neck cancer treated by platelet gel supernatant (PGS) and supportive medical treatment versus subjects treated by supportive medical treatment alone. MATERIALS AND METHODS:: Eighty patients with nonmetastatic head and neck cancer underwent curative or adjuvant radiotherapy. All patients underwent supportive medical treatment and/or PGS at the beginning and during radiotherapy. Sixteen patients received PGS in association with supportive medical treatment. To obtain 2 groups virtually randomized for important clinical characteristics subjects were matched, by propensity analysis, with a group of subjects (64 patients) treated with supportive medical treatment alone. RESULTS:: Subjects treated with standard supportive treatment experienced significant higher WHO grade 3/4 toxicity (55%; 35/64) than subjects treated by PGS (13%; 3/16). The reduced toxicity found in PGS group paralleled with the evidence that they developed later symptoms with respect to controls. The Cox proportional hazard model indicated that patients treated with standard supportive medical treatment experienced 2.7-fold increase (hazard ratio=2.7; 95% confidence interval, 1.3-5.7) in the occurrence of WHO grade 3/4 toxicity. PGS group significantly experienced higher quality of life than control groups as measured by OMWQ-HN. A significant decrease in the opioid analgesics usage was found in the PGS group. CONCLUSIONS:: These preliminary data should be interpreted with caution and could serve as a framework around which to design future trials
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