1,327 research outputs found
Application of linear switched reluctance motors to precision position control
Author name used in this publication: Norbert C. CheungRefereed conference paper2004-2005 > Academic research: refereed > Refereed conference paperVersion of RecordPublishe
Dual Conformal Properties of Six-Dimensional Maximal Super Yang-Mills Amplitudes
We demonstrate that the tree-level amplitudes of maximal super-Yang-Mills
theory in six dimensions, when stripped of their overall momentum and
supermomentum delta functions, are covariant with respect to the
six-dimensional dual conformal group. Using the generalized unitarity method,
we demonstrate that this property is also present for loop amplitudes. Since
the six-dimensional amplitudes can be interpreted as massive four-dimensional
ones, this implies that the six-dimensional symmetry is also present in the
massively regulated four-dimensional maximal super-Yang-Mills amplitudes.Comment: 20 pages, 3 figures, minor clarification, references update
Spinor Helicity and Dual Conformal Symmetry in Ten Dimensions
The spinor helicity formalism in four dimensions has become a very useful
tool both for understanding the structure of amplitudes and also for practical
numerical computation of amplitudes. Recently, there has been some discussion
of an extension of this formalism to higher dimensions. We describe a
particular implementation of the spinor-helicity method in ten dimensions.
Using this tool, we study the tree-level S-matrix of ten dimensional super
Yang-Mills theory, and prove that the theory enjoys a dual conformal symmetry.
Implications for four-dimensional computations are discussed.Comment: 24 pages, 1 figure
Local Spacetime Physics from the Grassmannian
A duality has recently been conjectured between all leading singularities of
n-particle N^(k-2)MHV scattering amplitudes in N=4 SYM and the residues of a
contour integral with a natural measure over the Grassmannian G(k,n). In this
note we show that a simple contour deformation converts the sum of Grassmannian
residues associated with the BCFW expansion of NMHV tree amplitudes to the CSW
expansion of the same amplitude. We propose that for general k the same
deformation yields the (k-2) parameter Risager expansion. We establish this
equivalence for all MHV-bar amplitudes and show that the Risager degrees of
freedom are non-trivially determined by the GL(k-2) "gauge" degrees of freedom
in the Grassmannian. The Risager expansion is known to recursively construct
the CSW expansion for all tree amplitudes, and given that the CSW expansion
follows directly from the (super) Yang-Mills Lagrangian in light-cone gauge,
this contour deformation allows us to directly see the emergence of local
space-time physics from the Grassmannian.Comment: 22 pages, 13 figures; v2: minor updates, typos correcte
An Exactly Solvable Model for the Integrability-Chaos Transition in Rough Quantum Billiards
A central question of dynamics, largely open in the quantum case, is to what
extent it erases a system's memory of its initial properties. Here we present a
simple statistically solvable quantum model describing this memory loss across
an integrability-chaos transition under a perturbation obeying no selection
rules. From the perspective of quantum localization-delocalization on the
lattice of quantum numbers, we are dealing with a situation where every lattice
site is coupled to every other site with the same strength, on average. The
model also rigorously justifies a similar set of relationships recently
proposed in the context of two short-range-interacting ultracold atoms in a
harmonic waveguide. Application of our model to an ensemble of uncorrelated
impurities on a rectangular lattice gives good agreement with ab initio
numerics.Comment: 29 pages, 5 figure
Circulating CD133+VEGFR2+ and CD34+VEGFR2+ cells and arterial function in patients with beta-thalassaemia major
Arterial dysfunction has been documented in patients with beta-thalassaemia major. This study aimed to determine the quantity and proliferative capacity of circulating CD133+VEGFR2+ and CD34+VEGFR2+ cells in patients with beta-thalassaemia major and those after haematopoietic stem cell transplantation (HSCT), and their relationships with arterial function. Brachial arterial flow-mediated dilation (FMD), carotid arterial stiffness, the quantity of these circulating cells and their number of colony-forming units (CFUs) were determined in 17 transfusion-dependent thalassaemia patients, 14 patients after HSCT and 11 controls. Compared with controls, both patient groups had significantly lower FMD and greater arterial stiffness. Despite having increased CD133+VEGFR2+ and CD34+VEGFR2+ cells, transfusion-dependent patients had significantly reduced CFUs compared with controls (p = 0.002). There was a trend of increasing CFUs across the three groups with decreasing iron load (p = 0.011). The CFUs correlated with brachial FMD (p = 0.029) and arterial stiffness (p = 0.02), but not with serum ferritin level. Multiple linear regression showed that CFU was a significant determinant of FMD (p = 0.043) and arterial stiffness (p = 0.02) after adjustment of age, sex, body mass index, blood pressure and serum ferritin level. In conclusion, arterial dysfunction found in patients with beta-thalassaemia major before and after HSCT may be related to impaired proliferation of CD133+VEGFR2+ and CD34+VEGFR2+ cells
Evaluation of Indirect Fluorescent Antibody Assays Compared to Rapid Influenza Diagnostic Tests for the Detection of Pandemic Influenza A (H1N1) pdm09
Performance of indirect fluorescent antibody (IFA) assays and rapid influenza diagnostic tests (RIDT) during the 2009 H1N1 pandemic was evaluated, along with the relative effects of age and illness severity on test accuracy. Clinicians and laboratories submitted specimens on patients with respiratory illness to public health from April to mid October 2009 for polymerase chain reaction (PCR) testing as part of pandemic H1N1 surveillance efforts in Orange County, CA; IFA and RIDT were performed in clinical settings. Sensitivity and specificity for detection of the 2009 pandemic H1N1 strain, now officially named influenza A(H1N1)pdm09, were calculated for 638 specimens. Overall, approximately 30% of IFA tests and RIDTs tested by PCR were falsely negative (sensitivity 71% and 69%, respectively). Sensitivity of RIDT ranged from 45% to 84% depending on severity and age of patients. In hospitalized children, sensitivity of IFA (75%) was similar to RIDT (84%). Specificity of tests performed on hospitalized children was 94% for IFA and 80% for RIDT. Overall sensitivity of RIDT in this study was comparable to previously published studies on pandemic H1N1 influenza and sensitivity of IFA was similar to what has been reported in children for seasonal influenza. Both diagnostic tests produced a high number of false negatives and should not be used to rule out influenza infection
Expression of tumour-specific antigens underlies cancer immunoediting
Cancer immunoediting is a process by which immune cells, particularly lymphocytes of the adaptive immune system, protect the host from the development of cancer and alter tumour progression by driving the outgrowth of tumour cells with decreased sensitivity to immune attack1, 2. Carcinogen-induced mouse models of cancer have shown that primary tumour susceptibility is thereby enhanced in immune-compromised mice, whereas the capacity for such tumours to grow after transplantation into wild-type mice is reduced2, 3. However, many questions about the process of cancer immunoediting remain unanswered, in part because of the known antigenic complexity and heterogeneity of carcinogen-induced tumours4. Here we adapted a genetically engineered, autochthonous mouse model of sarcomagenesis to investigate the process of cancer immunoediting. This system allows us to monitor the onset and growth of immunogenic and non-immunogenic tumours induced in situ that harbour identical genetic and histopathological characteristics. By comparing the development of such tumours in immune-competent mice with their development in mice with broad immunodeficiency or specific antigenic tolerance, we show that recognition of tumour-specific antigens by lymphocytes is critical for immunoediting against sarcomas. Furthermore, primary sarcomas were edited to become less immunogenic through the selective outgrowth of cells that were able to escape T lymphocyte attack. Loss of tumour antigen expression or presentation on major histocompatibility complex I was necessary and sufficient for this immunoediting process to occur. These results highlight the importance of tumour-specific-antigen expression in immune surveillance, and potentially, immunotherapy.National Institutes of Health (U.S.) (Grant 1 U54 CA126515-01)National Cancer Institute (U.S.) (Cancer Center Support Grant P30-CA14051)Margaret A. Cunningham Immune Mechanisms in Cancer Research Fellowship AwardJohnD. Proctor FoundationDaniel K. Ludwig Schola
Internal delensing of cosmic microwave background polarization B-Modes with the POLARBEAR experiment
International audienceUsing only cosmic microwave background polarization data from the polarbear experiment, we measure B-mode polarization delensing on subdegree scales at more than 5σ significance. We achieve a 14% B-mode power variance reduction, the highest to date for internal delensing, and improve this result to 22% by applying for the first time an iterative maximum a posteriori delensing method. Our analysis demonstrates the capability of internal delensing as a means of improving constraints on inflationary models, paving the way for the optimal analysis of next-generation primordial B-mode experiments
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