From Sociology and Economics to World History

World History has only recently emerged as a distinctive and vibrant field of study. Its origins arose from a cross-fertilization of economics, history, and comparative sociology, and from particular conjunctions of people and places in the 1980s and 1990s. World historians now, thanks to unprecedented access to quantitative historical data and international networks of scholars, can develop increasingly precise, formal, and detailed accounts of changes and comparisons across historical periods. However, our goal is not to create new master narratives or theories that predict a grand historical trajectory for mankind; rather we seek to better understand the similarities and differences among societies, and the likely consequences of those similarities and differences.World History has only recently emerged as a distinctive and vibrant field of study. Its origins arose from a cross-fertilization of economics, history, and comparative sociology, and from particular conjunctions of people and places in the 1980s and 1990s. World historians now, thanks to unprecedented access to quantitative historical data and international networks of scholars, can develop increasingly precise, formal, and detailed accounts of changes and comparisons across historical periods. However, our goal is not to create new master narratives or theories that predict a grand historical trajectory for mankind; rather we seek to better understand the similarities and differences among societies, and the likely consequences of those similarities and differences

The Once and Future Middle Kingdom: China’s Return to Dominance in the Global Economy

Im 16. und 17. Jahrhundert führten alle Wege nach China. Die Nachfrage Europas nach chinesischer Seide, Keramik und Tee führte die europäischen Kaufleute in den Orient. Als Europa industrialisiert war, dominierten die Europäer den Welthandel, indem sie eine Reihe von Stützpunkten und Kolonien in Afrika, im Indischen Ozean und in China errichteten. Heute versucht China, diesen „devianten“ Trend umzukehren und China wieder zu seiner „normalen“ Position als führende Wirtschaftsmacht zu verhelfen. China strebt nach einer Führungsrolle in den Bereichen Wind- und Sonnenenergie, künstlicher Intelligenz, Elektromobilität und Quantencomputer, um die beherrschende Macht unter den Volkswirtschaften des 21. Jahrhunderts zu werden. Außerdem errichtet China eigene Stützpunkte quer durch den Indischen Ozean und nach Südeuropa, um seine Kontrolle über diese Handelsrouten wiederherzustellen. Wenn China Erfolghat, wird es die letzten zweihundert Jahre der Weltwirtschaftsgeschichte umkehren und seine frühere Rolle als Hauptakteur in der globalen Wirtschaft wiederherstellen.In the sixteenth and seventeenth centuries, all roads led to China. Europe’s demand for Chinese silks, ceramics, and tea led European traders to the Orient. Then as Europe industrialized, Europeans came to dominate world trade, building a string of bases and colonies around Africa, across the Indian Ocean, and in China. Today, China is seeking to reverse this “deviant” trend and restore China to its “normal” position as the world’s dominant economy. Seeking leadership in wind and solar power, artificial intelligence, electric vehicles, and quantum computing to become the dominant power among twenty-first century economies, China is also building its own set of bases across the Indian Ocean and into southern Europe to reassert its control of these trade routes. If China succeeds, it will reverse the last two hundred years of world economic history and reassert its earlier role as the core actor in the global economy

Diazoxide choline extended‐release tablet in people with Prader‐Willi syndrome: results from long‐term open‐label study

Objective: This study assessed the effect of 1-year administration of diazoxide choline extended-release tablet (DCCR) on hyperphagia and other complications of Prader-Willi syndrome (PWS). Methods: The authors studied 125 participants with PWS, age ≥ 4 years, who were enrolled in the DESTINY PWS Phase 3 study and who received DCCR for up to 52 weeks in DESTINY PWS and/or its open-label extension. The primary efficacy endpoint was Hyperphagia Questionnaire for Clinical Trials (HQ-CT) score. Other endpoints included behavioral assessments, body composition, hormonal measures, and safety. Results: DCCR administration resulted in significant improvements in HQ-CT (mean [SE] −9.9 [0.77], p < 0.0001) and greater improvements in those with more severe baseline hyperphagia (HQ-CT > 22). Improvements were seen in aggression, anxiety, and compulsivity (all p < 0.0001). There were reductions in leptin, insulin, and insulin resistance, as well as a significant increase in adiponectin (all p < 0.004). Lean body mass was increased (p < 0.0001). Disease severity was reduced as assessed by clinician and caregiver (both p < 0.0001). Common treatment-emergent adverse events included hypertrichosis, peripheral edema, and hyperglycemia. Adverse events infrequently resulted in discontinuation (7.2%). Conclusions: DCCR administration to people with PWS was well tolerated and associated with broad-ranging improvements in the syndrome. Sustained administration of DCCR has the potential to reduce disease severity and the burden of care for families

Where you look matters for body perception: Preferred gaze location contributes to the body inversion effect

The Body Inversion Effect (BIE; reduced visual discrimination performance for inverted compared to upright bodies) suggests that bodies are visually processed configurally; however, the specific importance of head posture information in the BIE has been indicated in reports of BIE reduction for whole bodies with fixed head position and for headless bodies. Through measurement of gaze patterns and investigation of the causal relation of fixation location to visual body discrimination performance, the present study reveals joint contributions of feature and configuration processing to visual body discrimination. Participants predominantly gazed at the (body-centric) upper body for upright bodies and the lower body for inverted bodies in the context of an experimental paradigm directly comparable to that of prior studies of the BIE. Subsequent manipulation of fixation location indicates that these preferential gaze locations causally contributed to the BIE for whole bodies largely due to the informative nature of gazing at or near the head. Also, a BIE was detected for both whole and headless bodies even when fixation location on the body was held constant, indicating a role of configural processing in body discrimination, though inclusion of the head posture information was still highly discriminative in the context of such processing. Interestingly, the impact of configuration (upright and inverted) to the BIE appears greater than that of differential preferred gaze locations

Social Structure in the Explanation and Prediction of Social Discontinuities: A Response to Lempert's Critique of the Multipath Forecasting Project (MFP)

Response to Lempert: A Response to Multipath Forecastin