A companion to a quasar at redshift 4.7

There is a growing consensus that the emergence of quasars at high redshifts is related to the onset of galaxy formation, suggesting that the detection of concentrations of gas accompanying such quasars should provide clues about the early history of galaxies. Quasar companions have been recently identified at redshifts up to $z \approx 3$. Here we report observations of Lyman-$\alpha$ emission (a tracer of ionised hydrogen) from the companion to a quasar at $z$=4.702, corresponding to a time when the Universe was less than ten per cent of its present age. We argue that most of the emission arises in a gaseous nebula that has been photoionised by the quasar, but an additional component of continuum light -perhaps quasar light scattered from dust in the companion body, or emission from young stars within the nebula- appears necessary to explain the observations. These observations may be indicative of the first stages in the assembly of galaxy-sized structures.Comment: 8 pages, 4 figures, plain LaTeX. Accepted for publication in Natur

Metabolically healthy and unhealthy obesity: differential effects on myocardial function according to metabolic syndrome, rather than obesity.

BACKGROUND: The term 'metabolically healthy obese (MHO)' is distinguished using body mass index (BMI), yet BMI is a poor index of adiposity. Some epidemiological data suggest that MHO carries a lower risk of cardiovascular disease (CVD) or mortality than being normal weight yet metabolically unhealthy. OBJECTIVES: We aimed to undertake a detailed phenotyping of individuals with MHO by using imaging techniques to examine ectopic fat (visceral and liver fat deposition) and myocardial function. We hypothesised that metabolically unhealthy individuals (irrespective of BMI) would have adverse levels of ectopic fat and myocardial dysfunction compared with MHO individuals. SUBJECTS: Individuals were categorised as non-obese or obese (BMI ⩾30 kg m(-2)) and as metabolically healthy or unhealthy according to the presence or absence of metabolic syndrome. METHODS: Sixty-seven individuals (mean±s.d.: age 49±11 years) underwent measurement of (i) visceral, subcutaneous and liver fat using magnetic resonance imaging and proton magnetic resonance spectroscopy, (ii) components of metabolic syndrome, (iii) cardiorespiratory fitness and (iv) indices of systolic and diastolic function using tissue Doppler echocardiography. RESULTS: Cardiorespiratory fitness was similar between all groups; abdominal and visceral fat was highest in the obese groups. Compared with age- and BMI-matched metabolically healthy counterparts, the unhealthy (lean or obese) individuals had higher liver fat and decreased early diastolic strain rate, early diastolic tissue velocity and systolic strain indicative of subclinical systolic and diastolic dysfunction. The magnitude of dysfunction correlated with the number of components of metabolic syndrome but not with BMI or with the degree of ectopic (visceral or liver) fat deposition. CONCLUSIONS: Myocardial dysfunction appears to be related to poor metabolic health rather than simply BMI or fat mass. These data may partly explain the epidemiological evidence on CVD risk relating to the different obesity phenotypes

Neptune’s carbon monoxide profile and phosphine upper limits from Herschel/SPIRE: Implications for interior structure and formation

On Neptune, carbon monoxide and phosphine are disequilibrium species, and their abundance profiles can provide insights into interior processes and the external space environment. Here we use Herschel/SPIRE (Spectral and Photometric Imaging REceiver) observations from 14.9–51.5 cm-1 to obtain abundances from multiple CO and PH3 spectral features. For CO, we find that nine CO bands can be simultaneously fitted using a step profile with a 0.22 ppm tropospheric abundance, a 1.03 ppm stratospheric abundance, and a step transition pressure of 0.11 bar near the tropopause. This is in broad agreement with previous studies. However, we also find that the CO spectral features could be fitted, to well within measurement errors, with a profile that contains no tropospheric CO for pressure levels deeper than 0.5 bar, which is our preferred interpretation. This differs from previous studies that have assumed CO is well mixed throughout the troposphere, which would require an internal CO source to explain and a high O/H enrichment. Our interpretation removes the requirement for extreme interior O/H enrichment in thermochemical models and can finally reconcile D/H and CO measurements. If true, the lack of lower tropospheric CO would imply a decrease in Neptune’s interior water content, favouring a silicate-rich instead of an ice-rich interior. This would be consistent with a protoplanetary ice source with a similar D/H ratio to the current solar system comet population. The upper tropospheric and stratospheric CO at pressures less than 0.5 bar could then be entirely externally sourced from a giant impact as suggested by Lellouch et al.(2005). We also derive a 3-σ upper limit for PH3 of 1.1 ppb at 0.4–0.8 bar. This is the most stringent upper limit to-date and is entirely consistent with predictions from a simple photochemical model

Search for sterile neutrino mixing in the MINOS long-baseline experiment

A search for depletion of the combined flux of active neutrino species over a 735 km baseline is reported using neutral-current interaction data recorded by the MINOS detectors in the NuMI neutrino beam. Such a depletion is not expected according to conventional interpretations of neutrino oscillation data involving the three known neutrino flavors. A depletion would be a signature of oscillations or decay to postulated noninteracting sterile neutrinos, scenarios not ruled out by existing data. From an exposure of 3.18×1020 protons on target in which neutrinos of energies between ~500¿¿MeV and 120 GeV are produced predominantly as ¿µ, the visible energy spectrum of candidate neutral-current reactions in the MINOS far detector is reconstructed. Comparison of this spectrum to that inferred from a similarly selected near-detector sample shows that of the portion of the ¿µ flux observed to disappear in charged-current interaction data, the fraction that could be converting to a sterile state is less than 52% at 90% confidence level (C.L.). The hypothesis that active neutrinos mix with a single sterile neutrino via oscillations is tested by fitting the data to various models. In the particular four-neutrino models considered, the mixing angles ¿24 and ¿34 are constrained to be less than 11° and 56° at 90% C.L., respectively. The possibility that active neutrinos may decay to sterile neutrinos is also investigated. Pure neutrino decay without oscillations is ruled out at 5.4 standard deviations. For the scenario in which active neutrinos decay into sterile states concurrently with neutrino oscillations, a lower limit is established for the neutrino decay lifetime t3/m3>2.1×10-12¿¿s/eV at 90% C.L

Imputation of Assay Bioactivity Data Using Deep Learning.

We describe a novel deep learning neural network method and its application to impute assay pIC50 values. Unlike conventional machine learning approaches, this method is trained on sparse bioactivity data as input, typical of that found in public and commercial databases, enabling it to learn directly from correlations between activities measured in different assays. In two case studies on public domain data sets we show that the neural network method outperforms traditional quantitative structure-activity relationship (QSAR) models and other leading approaches. Furthermore, by focusing on only the most confident predictions the accuracy is increased to R2 > 0.9 using our method, as compared to R2 = 0.44 when reporting all predictions

Forward modelling low-spectral-resolution Cassini/CIRS observations of Titan

The Composite InfraRed Spectrometer (CIRS) instrument onboard the Cassini spacecraft performed 8.4 million spectral observations of Titan at resolutions between 0.5–15.5 cm-1. More than 3 million of these were acquired at a low spectral resolution (SR) (13.5–15.5 cm-1), which have excellent spatial and temporal coverage in addition to the highest spatial resolution and lowest noise per spectrum of any of the CIRS observations. Despite this, the CIRS low-SR dataset is currently underused for atmospheric composition analysis, as spectral features are often blended and subtle compared to those in higher SR observations. The vast size of the dataset also poses a challenge as an efficient forward model is required to fully exploit these observations. Here, we show that the CIRS FP3/4 nadir low-SR observations of Titan can be accurately forward modelled using a computationally efficient correlated-k method. We quantify wavenumber-dependent forward modelling errors, with mean 0.723 nW cm-2 sr-1/cm-1 (FP3: 600–890 cm-1) and 0.248 nW cm-2 sr-1/ cm-1 (FP4: 1240–1360 cm-1), that can be used to improve the rigour of future retrievals. Alternatively, in cases where more accuracy is required, we show observations can be forward modelled using an optimised line-by-line method, significantly reducing computation time

Autism as a disorder of neural information processing: directions for research and targets for therapy

The broad variation in phenotypes and severities within autism spectrum disorders suggests the involvement of multiple predisposing factors, interacting in complex ways with normal developmental courses and gradients. Identification of these factors, and the common developmental path into which theyfeed, is hampered bythe large degrees of convergence from causal factors to altered brain development, and divergence from abnormal brain development into altered cognition and behaviour. Genetic, neurochemical, neuroimaging and behavioural findings on autism, as well as studies of normal development and of genetic syndromes that share symptoms with autism, offer hypotheses as to the nature of causal factors and their possible effects on the structure and dynamics of neural systems. Such alterations in neural properties may in turn perturb activity-dependent development, giving rise to a complex behavioural syndrome many steps removed from the root causes. Animal models based on genetic, neurochemical, neurophysiological, and behavioural manipulations offer the possibility of exploring these developmental processes in detail, as do human studies addressing endophenotypes beyond the diagnosis itself

Ancient hydrothermal seafloor deposits in Eridania basin on Mars

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. The file attached is the Published/publisher’s pdf version of the article

Temporal variations in vertical cloud structure of Jupiter’s Great Red Spot, its surroundings and Oval BA from HST/WFC3 imaging

In this study, we present the evolution of the properties and vertical distribution of the hazes in Jupiter's Great Red Spot (GRS), its surroundings and Oval BA from 2015 to 2021. To retrieve the main atmospheric parameters, we model the spectral reflectivity of a number of dynamically and/or spectrally interesting regions with a radiative transfer tool that uses an optimal estimator scheme. The spectra of the selected regions are obtained from high-resolution Hubble Space Telescope Wide Field Camera 3 images that cover the spectral range from 200 to 900 nm. The a priori model atmosphere used to describe the various Jovian regions is taken from Anguiano-Arteaga et al. (2021, https://doi.org/10.1029/2021JE006996) for each corresponding area. We find that the biggest variations in the GRS occur in the optical thickness of the stratospheric and tropospheric haze layers starting in 2019 and in the mean size of the tropospheric haze particles in 2018. The absorption spectra of both hazes show little variations among the analyzed regions and years, with the stratospheric haze properties seeming compatible with the chromophore proposed by Carlson et al. (2016, https://doi.org/10.1016/j.icarus.2016.03.008). We report a color change of Oval BA from red to white during these years that, according to our models, can be mostly explained in terms of a decrease in the stratospheric haze optical depth

Search for Sterile Neutrinos Mixing with Muon Neutrinos in MINOS

We report results of a search for oscillations involving a light sterile neutrino over distances of 1.04 and 735 km in a νμ-dominated beam with a peak energy of 3 GeV. The data, from an exposure of 10.56 × 10^20 protons on target, are analyzed using a phenomenological model with one sterile neutrino. We constrain the mixing parameters θ24 and Δm41^2 and set limits on parameters of the four-dimensional Pontecorvo-Maki- Nakagawa-Sakata matrix, |Uμ4|2 and |Uτ4|2, under the assumption that mixing between νe and νs is negligible (|Ue4|^2 = 0). No evidence for νμ → νs transitions is found and we set a world-leading limit on θ24 for values of Δm41^2 ≲ 1 eV^2