Assessing the impact of rail investment on housing prices in north-west Sydney

Rail investments alter the accessibility and amenity of residential properties, and thus affect housing prices and overall affordability. This project investigates the impact of the Epping-Chatswood rail link in North-west Sydney on home prices, testing out alternative methodologies for estimating price impacts through spatial analysis of historical property sales data obtained from the RP Data Australia. The paper focuses on one station, comparing price trends before and after the construction of the rail link was announced in 2002, and before and after the opening of the rail line in early 2009. The paper concludes with an assessment of the usefulness of alternative methodologies

Traces, tiles and fleeting moments: art and the temporalities of geomedia

This chapter looks at the ways artists working with geomedia technologies have exposed and exploited the complex temporalities of digital mapping, dealing first with the trace of movement in locative media art practices of the early to mid 2000s, and secondly with the appropriation of remote sensing imagery and Street View imagery by artists. The aim is to challenge the idea that geomedia's only temporal effects are ones of timelessness; crucial to this challenge is a separation out of two different versions of timelessness that are often ascribed to cartography and new media respectively, and sometimes conflated. I argue that the stress on atemporality effects in studies of the aesthetics and cultural impact of geomedia, and the conflation of the cartographic and technological/cultural versions of timelessness in particular, moves too quickly to read a surfeit of temporal markers as a collapse of temporality as such

Moving bodies and the map: relational and absolute conceptions of space in GPS based art

Geographers and social scientists have argued that geospatial technologies are contributing to new understandings of space as relational and of cartography as processual and performative rather than representational. There is a fundamental tension in the fact that these new understandings of space and cartography are facilitated by a technology that epitomises an absolute conception of space. The GPS trace has been employed in new media art practices since the early 1990s, and is particularly evident in the locative media genre that emerged in the early 2000s. This article deals with the use of GPS by artists, and the role of art in producing these new understandings of space. The mapped trace of movement has been identified as an inadequate capture of spatial practices. This position –influentially articulated by Michel de Certeau – is associated with a tradition of thought that privileges time as the dimension of dynamism and denigrates space as the dimension of stasis and fixity. This denigrated space is the absolute space of cartography as it has been traditionally understood. This article uses GPS-based artworks to explore different relational understandings of space in which movement is primary, drawing on the work of Tim Ingold, Bruno Latour and Nigel Thrift. By looking at the ways in which media artists have addressed or exploited the tension between the absolute spatiality of cartography and the relational spatiality of movement in their work, it seeks to find a way past seeing these different conceptions of space in such starkly oppositional terms

BZ-MC-BP Model for Jet Production from Black Hole Accretion Disc

Three energy mechanisms invoking large-scale magnetic fields are incorporated in a model to interpret jet production in black hole (BH) systems, i.e., the Blandford-Znajek (BZ), the magnetic coupling (MC) and Blandford-Payne (BP) processes. These energy mechanisms can coexist in BH accretion disc based on the magnetic field configurations constrained by the screw instability, provided that the BH spin and the power-law index indicating the variation of the magnetic field at an accretion disc are greater than some critical values. In this model the jets are driven by the BZ process in the Poynting flux regime and by the BP process in the hydromagnetic regime, being consistent with the spine/sheath jet structure observed in BH sources of stellar and supermassive size.Comment: 9 pages, 6 figures, accepted by MNRA

p-species integrable reaction-diffusion processes

We consider a process in which there are p-species of particles, i.e. A_1,A_2,...,A_p, on an infinite one-dimensional lattice. Each particle $A_i$ can diffuse to its right neighboring site with rate $D_i$, if this site is not already occupied. Also they have the exchange interaction A_j+A_i --> A_i+A_j with rate $r_{ij}.$ We study the range of parameters (interactions) for which the model is integrable. The wavefunctions of this multi--parameter family of integrable models are found. We also extend the 2--species model to the case in which the particles are able to diffuse to their right or left neighboring sites.Comment: 16 pages, LaTe

A Selberg integral for the Lie algebra A_n

A new q-binomial theorem for Macdonald polynomials is employed to prove an A_n analogue of the celebrated Selberg integral. This confirms the g=A_n case of a conjecture by Mukhin and Varchenko concerning the existence of a Selberg integral for every simple Lie algebra g.Comment: 32 page

Cellular sheddases are induced by Merkel Cell Polyomavirus Small Tumour Antigen to mediate cell dissociation and invasiveness

Merkel cell carcinoma (MCC) is an aggressive skin cancer with a high propensity for recurrence and metastasis. Merkel cell polyomavirus (MCPyV) is recognised as the causative factor in the majority of MCC cases. The MCPyV small tumour antigen (ST) is considered to be the main viral transforming factor, however potential mechanisms linking ST expression to the highly metastatic nature of MCC are yet to be fully elucidated. Metastasis is a complex process, with several discrete steps required for the formation of secondary tumour sites. One essential trait that underpins the ability of cancer cells to metastasise is how they interact with adjoining tumour cells and the surrounding extracellular matrix. Here we demonstrate that MCPyV ST expression disrupts the integrity of cell-cell junctions, thereby enhancing cell dissociation and implicate the cellular sheddases, A disintegrin and metalloproteinase (ADAM) 10 and 17 proteins in this process. Inhibition of ADAM 10 and 17 activity reduced MCPyV ST-induced cell dissociation and motility, attributing their function as critical to the MCPyV-induced metastatic processes. Consistent with these data, we confirm that ADAM 10 and 17 are upregulated in MCPyV-positive primary MCC tumours. These novel findings implicate cellular sheddases as key host cell factors contributing to virus-mediated cellular transformation and metastasis. Notably, ADAM protein expression may be a novel biomarker of MCC prognosis and given the current interest in cellular sheddase inhibitors for cancer therapeutics, it highlights ADAM 10 and 17 activity as a novel opportunity for targeted interventions for disseminated MCC

Phenotypic and molecular assessment of seven patients with 6p25 deletion syndrome: Relevance to ocular dysgenesis and hearing impairment

BACKGROUND: Thirty-nine patients have been described with deletions involving chromosome 6p25. However, relatively few of these deletions have had molecular characterization. Common phenotypes of 6p25 deletion syndrome patients include hydrocephalus, hearing loss, and ocular, craniofacial, skeletal, cardiac, and renal malformations. Molecular characterization of deletions can identify genes that are responsible for these phenotypes. METHODS: We report the clinical phenotype of seven patients with terminal deletions of chromosome 6p25 and compare them to previously reported patients. Molecular characterization of the deletions was performed using polymorphic marker analysis to determine the extents of the deletions in these seven 6p25 deletion syndrome patients. RESULTS: Our results, and previous data, show that ocular dysgenesis and hearing impairment are the two most highly penetrant phenotypes of the 6p25 deletion syndrome. While deletion of the forkhead box C1 gene (FOXC1) probably underlies the ocular dysgenesis, no gene in this region is known to be involved in hearing impairment. CONCLUSIONS: Ocular dysgenesis and hearing impairment are the two most common phenotypes of 6p25 deletion syndrome. We conclude that a locus for dominant hearing loss is present at 6p25 and that this locus is restricted to a region distal to D6S1617. Molecular characterization of more 6p25 deletion patients will aid in refinement of this locus and the identification of a gene involved in dominant hearing loss