Clinical and radiographic evaluations of healing femoral fractures managed with conventional and novel allo-cadaveric bone plates in dogs

Femoral diaphyseal fractures are usually amenable to reduction with the use of orthodox fixation implants, which in most cases are expensive and cause intense stress to the patient, hence the need for safer, new biomaterials. This study assessed the use of allo-cadaveric bone plates (CBP-A) and conventional bone plates in managing femoral fractures in dogs. A total of four 8-12 kg Nigerian indigenous dogs were randomly divided into two groups, with each consisting of a male and female dog. Sterilized osteotome wire was employed to surgically create transverse mid-shaft femoral fractures in all the dogs. The fractures in Group I dogs were managed using Vitallium-alloy bone plates and served as control, while Group II fractures were reduced and fixed using CBP-A. Clinical and radiographic assessments for three months were carried out to compare the fracture healing between the groups. Results showed an early stabilization of vital parameters with a premature attempt to use the operated limb on days 4 and 5 post-reduction in groups I and II, respectively. The radiographs revealed good fracture reduction and fixation in all the dogs with the gradual disappearance of the fracture line, as well as progressive bone remodelling as the fracture healing advanced through the sixth week. At 12 weeks, there was distinct medullary and cortical continuity in all the dogs. Therefore, the novel CBP-A used in this study has effectively provided the needed fixation stability with minimal external immobilization for the repair of dog femoral fractures; hence, it should be recommended for use

Determining the optimal range of coupling coefficient to suppress decline in WPTs efficiency due to increased resistance with temperature rise

The continuous operation of the wireless power transfer system (WPTS) under high-frequency switching activity might cause a temperature rise in various system\u27s components. That temperature rise might increase the resistance of the primary and secondary coils, which will lead to a significant decline in the system\u27s efficiency. To address this problem at the design stage, we investigate the optimal range of the coupling coefficient that suppresses the efficiency drop due to the increasing resistance of the WPTS components. The proposed optimal range of the coupling coefficient can also ensure the output power requirements of the WPTS. Using four different WPTSs, the determination method for the optimal range of coupling coefficients under different system operational frequencies was developed and implemented. A 3-kW resonant experimental prototype WPTS was designed and built to validate the proposed coupling coefficients experimentally. The experimental results show that the optimized coupling range successfully suppressed the efficiency decline resulting from the increasing resistance caused by temperature rise

A Layer-Wise Information Reinforcement Approach to Improve Learning in Deep Belief Networks

With the advent of deep learning, the number of works proposing new methods or improving existent ones has grown exponentially in the last years. In this scenario, "very deep" models were emerging, once they were expected to extract more intrinsic and abstract features while supporting a better performance. However, such models suffer from the gradient vanishing problem, i.e., backpropagation values become too close to zero in their shallower layers, ultimately causing learning to stagnate. Such an issue was overcome in the context of convolution neural networks by creating "shortcut connections" between layers, in a so-called deep residual learning framework. Nonetheless, a very popular deep learning technique called Deep Belief Network still suffers from gradient vanishing when dealing with discriminative tasks. Therefore, this paper proposes the Residual Deep Belief Network, which considers the information reinforcement layer-by-layer to improve the feature extraction and knowledge retaining, that support better discriminative performance. Experiments conducted over three public datasets demonstrate its robustness concerning the task of binary image classification

Delineation of potential managed aquifer recharge sites of Kuchlak sub-basin, Balochistan, using remote sensing and GIS

In the Kuchlak Sub-Basin (Pakistan), groundwater is overexploited, resulting in growing stress on groundwater resources. The water table level has declined rapidly due to intensive pumping. Artificial recharge methods and good management strategies are vital for the sustainable production of groundwater resources. Managed aquifer recharge is an artificial way of recharging the subsurface aquifers using surplus surface water, treated wastewater, and stormwater. It is a potential strategy for increasing freshwater supply and adapting to climate change. The present study proposes a method to delineate potential zones for MAR suitability in the Kuchlak Sub-Basin. INOWAS, a web-based tool, is utilized for narrowing down the available MAR techniques based on the hydrogeologic parameter and objectives of the study area. A geographic information system (GIS) coupled with the multi-criteria decision analysis (MCDA), commonly known as GIS-MCDA, is used to develop the MAR suitability map. Six criterion maps, including geology, land use, slope analysis, drainage density, soil, and rainfall, were created in ArcGIS for suitability mapping. The criterion maps are ranked and weighted based on their relative contribution to the groundwater recharge and published literature using the Multi Influence Factor (MIF) method. The final suitability map was developed by overlaying all the criterion maps using a weighted linear combination (WLC) technique. The MAR suitability map was divided into five zones, namely, very high, high, moderate, very low, and low. The unsuitable zones reflect the urban and slope constraints that reduce surface infiltration. The suitability map reveals that 45% of the Kuchlak Sub-Basin exists in a very high-high suitability zone, 33% in moderate, and 17% in a very low-low suitability zone, while 5% of the study area was unsuitable due to the urban and slope constraints. The MAR suitability map developed in this study can serve as a basis for conducting a focused analysis of MAR implementation. Furthermore, the technique and results of this study may aid in mapping MAR suitability in any arid or semi-arid region

Energy-Aware Radio Resource Management in D2D-Enabled Multi-Tier HetNets

Hybrid networks consisting of both millimeter wave (mmWave) and microwave (μW) capabilities are strongly contested for next-generation cellular communications. A similar avenue of current research is device-to-device (D2D) communications, where users establish direct links with each other rather than using central base stations. However, a hybrid network, where D2D transmissions coexist, requires special attention in terms of efficient resource allocation. This paper investigates dynamic resource sharing between network entities in a downlink transmission scheme to maximize energy efficiency (EE) of the cellular users (CUs) served by either (μW) macrocells or mmWave small cells while maintaining a minimum quality-of-service (QoS) for the D2D users. To address this problem, first, a self-adaptive power control mechanism for the D2D pairs is formulated, subject to an interference threshold for the CUs while satisfying their minimum QoS level. Subsequently, an EE optimization problem, which is aimed at maximizing the EE for both CUs and D2D pairs, has been solved. Simulation results demonstrate the effectiveness of our proposed algorithm, which studies the inherent tradeoffs between system EE, system sum rate, and outage probability for various QoS levels and varying densities of D2D pairs and CUs

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

Background & Aims: Hepatocyte-like cells (HLCs), differentiated from pluripotent stem cells by the use of soluble factors, can model human liver function and toxicity. However, at present HLC maturity and whether any deficit represents a true fetal state or aberrant differentiation is unclear and compounded by comparison to potentially deteriorated adult hepatocytes. Therefore, we generated HLCs from multiple lineages, using two different protocols, for direct comparison with fresh fetal and adult hepatocytes. Methods: Protocols were developed for robust differentiation. Multiple transcript, protein and functional analyses compared HLCs to fresh human fetal and adult hepatocytes. Results: HLCs were comparable to those of other laboratories by multiple parameters. Transcriptional changes during differentiation mimicked human embryogenesis and showed more similarity to pericentral than periportal hepatocytes. Unbiased proteomics demonstrated greater proximity to liver than 30 other human organs or tissues. However, by comparison to fresh material, HLC maturity was proven by transcript, protein and function to be fetal-like and short of the adult phenotype. The expression of 81% phase 1 enzymes in HLCs was significantly upregulated and half were statistically not different from fetal hepatocytes. HLCs secreted albumin and metabolized testosterone (CYP3A) and dextrorphan (CYP2D6) like fetal hepatocytes. In seven bespoke tests, devised by principal components analysis to distinguish fetal from adult hepatocytes, HLCs from two different source laboratories consistently demonstrated fetal characteristics. Conclusions: HLCs from different sources are broadly comparable with unbiased proteomic evidence for faithful differentiation down the liver lineage. This current phenotype mimics human fetal rather than adult hepatocytes

Biopiracy <i>versus </i>one-world medicine – from colonial relicts to global collaborative concepts

Background: Practices of biopiracy to use genetic resources and indigenous knowledge by Western companies without benefit-sharing of those, who generated the traditional knowledge, can be understood as form of neocolonialism.Hypothesis: : The One-World Medicine concept attempts to merge the best of traditional medicine from developing countries and conventional Western medicine for the sake of patients around the globe.Study design: Based on literature searches in several databases, a concept paper has been written. Legislative initiatives of the United Nations culminated in the Nagoya protocol aim to protect traditional knowledge and regulate benefit-sharing with indigenous communities. The European community adopted the Nagoya protocol, and the corresponding regulations will be implemented into national legislation among the member states. Despite pleasing progress, infrastructural problems of the health care systems in developing countries still remain. Current approaches to secure primary health care offer only fragmentary solutions at best. Conventional medicine from industrialized countries cannot be afforded by the impoverished population in the Third World. Confronted with exploding costs, even health systems in Western countries are endangered to burst. Complementary and alternative medicine (CAM) is popular among the general public in industrialized countries, although the efficacy is not sufficiently proven according to the standards of evidence-based medicine. CAM is often available without prescription as over-the-counter products with non-calculated risks concerning erroneous self-medication and safety/toxicity issues. The concept of integrative medicine attempts to combine holistic CAM approaches with evidence-based principles of conventional medicine.Conclusion: To realize the concept of One-World Medicine, a number of standards have to be set to assure safety, efficacy and applicability of traditional medicine, e.g. sustainable production and quality control of herbal products, performance of placebo-controlled, double-blind, randomized clinical trials, phytovigilance, as well as education of health professionals and patients