Emotional, cognitive and behavioral self-regulation in forensic psychiatric patients:Changes over time and associations with childhood trauma, identity and personality pathology

The construct of self-regulation is of particular interest to the forensic psychiatric practice due to its associations with both clinical and criminal outcomes, as well as recidivism. However, research on different components of self-regulation within forensic psychiatric practice is rare. The current study aimed to gain knowledge on the construct of self-regulation in a sample of forensic psychiatric patients (N = 94). Firstly, by investigating change of emotional, behavioral and cognitive self-regulation over the course of 12 months in state-mandated care in a treatment facility. Secondly, by looking at the associations between these three elements of self-regulation and childhood trauma, identity dysfunction and personality pathology. Repeated measures ANOVA showed little to no difference in average self-regulation over time (only for behavioral regulation), and rank-order stability was relatively high in most cases. Path analysis showed that: emotion regulation was associated with all outcomes; behavioral regulation with all except childhood trauma and detachment; and cognitive regulation only with antagonism and negative affectivity. Findings suggest short-term changes are unlikely and indicate relative importance of emotional, and to some extent behavioral regulation for clinical practice. However, due to sample size restrictions, interpretations should be made with caution

Nonlinear diffusion & thermo-electric coupling in a two-variable model of cardiac action potential

This work reports the results of the theoretical investigation of nonlinear dynamics and spiral wave breakup in a generalized two-variable model of cardiac action potential accounting for thermo-electric coupling and diffusion nonlinearities. As customary in excitable media, the common Q10 and Moore factors are used to describe thermo-electric feedback in a 10-degrees range. Motivated by the porous nature of the cardiac tissue, in this study we also propose a nonlinear Fickian flux formulated by Taylor expanding the voltage dependent diffusion coefficient up to quadratic terms. A fine tuning of the diffusive parameters is performed a priori to match the conduction velocity of the equivalent cable model. The resulting combined effects are then studied by numerically simulating different stimulation protocols on a one-dimensional cable. Model features are compared in terms of action potential morphology, restitution curves, frequency spectra and spatio-temporal phase differences. Two-dimensional long-run simulations are finally performed to characterize spiral breakup during sustained fibrillation at different thermal states. Temperature and nonlinear diffusion effects are found to impact the repolarization phase of the action potential wave with non-monotone patterns and to increase the propensity of arrhythmogenesis

Laparoscopic versus Open Surgery in Complicated Appendicitis in Children Less Than 5 Years Old: A Six-Year Single-Centre Experience

Introduction. Acute appendicitis is the most common surgical emergency in the pediatric population. The peak incidence occurs in the first decade of life, while it is uncommon to face appendicitis in children younger than 5 years of age. Laparoscopy is now demonstrated to be the optimal approach also to treat complicated appendicitis, but in very young children this standardized operation is not always easy to perform. Material and Methods. From January 2009 to December 2015 we operated on 525 acute appendicitis, with 120 patients less than 5 years of age. Results. 90 children had a complicated appendicitis (localized or diffuse peritonitis): 43 (48%) were operated on by open approach and 47 (52%) by laparoscopy. The overall incidence of postoperative complications was greater in the open appendectomy group (63% versus 26%) and all severe complications requiring reintervention (6% of cases: 3 postoperative abscesses resolved with ultrasound guided percutaneous abscess drainage; 1 tubal surgery for salpingitis; 1 adhesion-related ileus requiring relaparotomy) were mostly associated with open surgery. Conclusions. Laparoscopic surgery resulted as the best approach for treating complicated appendicitis also in younger children, with minor and less severe postoperative complications compared to open surgery

Starter Cultures for Sparkling Wine

The sparkling wine market has expanded in recent years, boosted by the increasing demand of the global market. As for other fermented beverages, technological yeasts and bacteria selected to design commercial starter cultures represent key levers to maximize product quality and safety. The increasing economic interest in the sector of sparkling wine has also implied a renewed interest in microbial resource management. In this review, after a brief introduction, we report an overview of the main characterization criteria in order to select Saccharomyces cerevisiae strains suitable for use as starter cultures for the production of base wines and to drive re-fermentation of base wines to obtain sparkling wines. Particular attention has been reserved to the technological characterization aspects of re-fermenting phenotypes. We also analysed the possible uses of selected non-Saccharomyces and malolactic strains in order to differentiate specific productions. Finally, we highlighted the main safety aspects related to microbes of enological interest and underlined some microbial-based biotechnological applications helpful to pursue product and process innovations. Overall, the sparkling wine industry may find a relevant benefit from the exploitation of the wide resources associated with vineyard/wine microbial diversity

The Suzaku view of 3C 382

We present a long Suzaku observation of 3C 382. A Swift BAT spectrum from the 58-month survey is also analyzed, together with an archival XMM-Newton EPIC exposure. Our main result is the finding with Suzaku of a broad FeK line with a relativistic profile consistent with emission from an accretion disk at tens of gravitational radii from the central black hole. The XIS data indicate emission from highly ionized iron and allow us to set tight, albeit model-dependent, constraints on the inner and outer radii of the disk reflecting region, r_in~10r_g and r_out~20r_g, respectively, and on the disk inclination, i~30deg. Two ionized reflection components are possibly observed, with similar contributions of ~10% to the total continuum. A highly ionized one, with log_xi~3, which successfully models the relativistic line and a mildly ionized one, with log_xi~1.5, which models the narrow Fe K line and high energy hump. When both these components are included, there is no further requirement for an additional black body soft excess below 2keV. The Suzaku data confirm the presence of a warm absorber previously known from grating studies. After accounting for all the spectral features, the intrinsic photon index of the X-ray continuum is ~1.8 with a cutoff energy at ~200keV, consistent with Comptonization models and excluding jet-related emission up to these energies. Comparison of the X-ray properties of 3C 382 and other BLRGs to Seyferts confirms the idea that the distinction between radio-loud and radio-quiet AGN at X-rays is blurred.Comment: Accepted for publication in Ap

Local behavior of p-harmonic Green's functions in metric spaces

We describe the behavior of p-harmonic Green's functions near a singularity in metric measure spaces equipped with a doubling measure and supporting a Poincar\'e inequality

Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli

PURPOSE: Recent in vitro studies suggested that the autocrine leptin loop might contribute to breast cancer development by enhancing cell growth and survival. To evaluate whether the leptin system could become a target in breast cancer therapy, we examined the expression of leptin and its receptor (ObR) in primary and metastatic breast cancer and noncancer mammary epithelium. We also studied whether the expression of leptin/ObR in breast cancer can be induced by obesity-related stimuli, such as elevated levels of insulin, insulin-like growth factor-I (IGF-I), estradiol, or hypoxic conditions. EXPERIMENTAL DESIGN: The expression of leptin and ObR was examined by immunohistochemistry in 148 primary breast cancers and 66 breast cancer metastases as well as in 90 benign mammary lesions. The effects of insulin, IGF-I, estradiol, and hypoxia on leptin and ObR mRNA expression were assessed by reverse transcription-PCR in MCF-7 and MDA-MB-231 breast cancer cell lines. RESULTS: Leptin and ObR were significantly overexpressed in primary and metastatic breast cancer relative to noncancer tissues. In primary tumors, leptin positively correlated with ObR, and both biomarkers were most abundant in G3 tumors. The expression of leptin mRNA was enhanced by insulin and hypoxia in MCF-7 and MDA-MB-231 cells, whereas IGF-I and estradiol stimulated leptin mRNA only in MCF-7 cells. ObR mRNA was induced by insulin, IGF-I, and estradiol in MCF-7 cells and by insulin and hypoxia in MDA-MB-231 cells. CONCLUSIONS: Leptin and ObR are overexpressed in breast cancer, possibly due to hypoxia and/or overexposure of cells to insulin, IGF-I, and/or estradiol

Broad emission lines for negatively spinning black holes

We present an extended scheme for the calculation of the profiles of emission lines from accretion discs around rotating black holes. The scheme includes discs with angular momenta which are parallel and antiparallel with respect to the black hole's angular momentum, as both configurations are assumed to be stable (King et al., 2005). We discuss line shapes for such discs and present a code for modelling observational data with this scheme in X-ray data analysis programs. Based on a Green's function approach, an arbitrary radius dependence of the disc emissivity and arbitrary limb darkening laws can be easily taken into account, while the amount of precomputed data is significantly reduced with respect to other available models.Comment: 7 pages, 6 figures; accepted by MNRAS for Publication, now matches the proof read versio