A perspective on the landscape problem

I discuss the historical roots of the landscape problem and propose criteria for its successful resolution. This provides a perspective to evaluate the possibility to solve it in several of the speculative cosmological scenarios under study including eternal inflation, cosmological natural selection and cyclic cosmologies.Comment: Invited contribution for a special issue of Foundations of Physics titled: Forty Years Of String Theory: Reflecting On the Foundations. 31 pages, no figure

Proton propagation in nuclei studied in the (e,e’p) reaction

Proton propagation in nuclei was studied using the (e,e’p) reaction in the quasifree region. The coincidence (e,e’p) cross sections were measured at an electron angle of 50.4° and proton angles of 50.1°, 58.2°, 67.9°, and 72.9° for 12C, 27Al, 58Ni, and 181Ta targets at a beam energy of 779.5 MeV. The average outgoing proton energy was 180 MeV. The ratio of the (e,e’p) yield to the simultaneously measured (e,e’) yield was compared to that calculated in the plane-wave impulse approximation and an experimental transmission defined. These experimental transmissions are considerably larger (a factor of ∼2 for 181Ta) than those one would calculate from the free N-N cross sections folded into the nuclear density distribution. A new calculation that includes medium effects (N-N correlations, density dependence of the N-N cross sections and Pauli suppression) accounts for this increase

Some remarks on the angular momenta of galaxies, their clusters and superclusters

We discuss the relation between angular momenta and masses of galaxy structures base on the Li model of the universe with global rotation. In our previous paper (God{\l}owski et al 2002) it was shown that the model predicts the presence of a minimum in this relation. In the present paper we discuss observational evidence allowing us to verify this relation. We find null angular momentum J=0 for the masses corresponding to mass of galaxy grups and non-vanishing angular momenta for other galactic structures. We check these theoretical predictions analysing Tully's galaxy grups. The existing data comparing alignment in different galactic structure are consistent with obtained theoretical relation $J(M)$ if we interpret the groving alignment as the galactic increasing angular momenta in the galactic structure.Comment: 20 pages 1 figure. GRG accepte

Dynamics of the Universe with global rotation

We analyze dynamics of the FRW models with global rotation in terms of dynamical system methods. We reduce dynamics of these models to the FRW models with some fictitious fluid which scales like radiation matter. This fluid mimics dynamically effects of global rotation. The significance of the global rotation of the Universe for the resolution of the acceleration and horizon problems in cosmology is investigated. It is found that dynamics of the Universe can be reduced to the two-dimensional Hamiltonian dynamical system. Then the construction of the Hamiltonian allows for full classification of evolution paths. On the phase portraits we find the domains of cosmic acceleration for the globally rotating universe as well as the trajectories for which the horizon problem is solved. We show that the FRW models with global rotation are structurally stable. This proves that the universe acceleration is due to the global rotation. It is also shown how global rotation gives a natural explanation of the empirical relation between angular momentum for clusters and superclusters of galaxies. The relation $J \sim M^2$ is obtained as a consequence of self similarity invariance of the dynamics of the FRW model with global rotation. In derivation of this relation we use the Lie group of symmetry analysis of differential equation.Comment: Revtex4, 22 pages, 5 figure

Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.

The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading target for next-generation vaccines against the disease-causing blood-stage of malaria. However, little is known about how human antibodies confer functional immunity against this antigen. We isolated a panel of human monoclonal antibodies (mAbs) against PfRH5 from peripheral blood B cells from vaccinees in the first clinical trial of a PfRH5-based vaccine. We identified a subset of mAbs with neutralizing activity that bind to three distinct sites and another subset of mAbs that are non-functional, or even antagonistic to neutralizing antibodies. We also identify the epitope of a novel group of non-neutralizing antibodies that significantly reduce the speed of red blood cell invasion by the merozoite, thereby potentiating the effect of all neutralizing PfRH5 antibodies as well as synergizing with antibodies targeting other malaria invasion proteins. Our results provide a roadmap for structure-guided vaccine development to maximize antibody efficacy against blood-stage malaria. Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved

Proton propagation in nuclei studied in the A dependence of the (e,e’p) reaction in the quasifree region

The A dependence of the (e,e’p) reaction in the quasifree region has been measured at an average Q2 of 0.33 (GeV/c)2 for targets of 12C, 27Al, 58Ni, and 181Ta. The outgoing proton kinetic energy was 180±30 MeV. By comparing the ratio of (e,e’p) coincidence to (e,e’) singles yields, average proton transmissions are obtained for each target. The resulting ‘‘mean free path’’ or, more precisely, the attenuation length for protons in the nucleus is significantly longer than expectations based on the free nucleon-nucleon cross section