277 research outputs found
Understanding Pediatric Dentistsâ Dental Caries Management Treatment Decisions: A Conjoint Experiment
When traditional ranking
and rating surveys are used to
assess dentistsâ treatment decisions, the
patientâs source of payment appears
to be of little importance. Therefore,
this study used the marketing research
tool conjoint analysis to investigate the
relative impact of source of payment
along with the childâs age and cooperativeness
on pediatric dentistsâ willingness
to use Atraumatic Restorative
Treatment (ART) to restore posterior
primary teeth. A conjoint survey was
completed by 707 pediatric dentists.
Three factors (age of the child, cooperativeness,
type of insurance) were varied
across 3 levels to create 9 patient
scenarios. The relative weights that
dentists placed on these factors in the
restorative treatment decision process
were determined by conjoint analysis.
âCooperativenessâ (52%) was the most
important factor, âage of the childâ
(26%) the second-most important factor,
followed by âinsurance status of
the childâ (22%). For the third factor,
insurance, pediatric dentists were
least willing to use ART with publicly
insured children (â0.082), and this
was significantly different from their
willingness to use ART with uninsured children (0.010) but not significantly
different than their willingness to use
ART for children with private insurance
(0.073). Unlike traditional ranking
and rating tools, conjoint analysis
found that the insurance status of
the patient appeared to be an important
factor in dentistsâ decisions about
different restorative treatment options.
When pediatric dentists were forced
to make tradeoffs among different
patientsâ factors, they were most willing
to use ART technique with young,
uncooperative patients when they had
no insurance.This project was funded by National
Institutes of Health / National Institute
of Dental and Craniofacial Research (T32
grant DEO 14678-06) and the Academic
Fellowship Program (Zamalah) for the
development of higher education. The
authors declare no potential conflicts of
interest with respect to the authorship
and/or publication of this article
A Glimpse Far into the Future: Understanding Long-term Crowd Worker Quality
Microtask crowdsourcing is increasingly critical to the creation of extremely
large datasets. As a result, crowd workers spend weeks or months repeating the
exact same tasks, making it necessary to understand their behavior over these
long periods of time. We utilize three large, longitudinal datasets of nine
million annotations collected from Amazon Mechanical Turk to examine claims
that workers fatigue or satisfice over these long periods, producing lower
quality work. We find that, contrary to these claims, workers are extremely
stable in their quality over the entire period. To understand whether workers
set their quality based on the task's requirements for acceptance, we then
perform an experiment where we vary the required quality for a large
crowdsourcing task. Workers did not adjust their quality based on the
acceptance threshold: workers who were above the threshold continued working at
their usual quality level, and workers below the threshold self-selected
themselves out of the task. Capitalizing on this consistency, we demonstrate
that it is possible to predict workers' long-term quality using just a glimpse
of their quality on the first five tasks.Comment: 10 pages, 11 figures, accepted CSCW 201
The Role of Subclass Switching in the Pathogenesis of Endemic Pemphigus Foliaceus
Endemic pemphigus foliaceus, like the sporadic form seen in the developed world, is mediated by IgG antibodies to desmoglein-1. We studied an endemic focus in Limao Verde, Brazil, where disease prevalence is 3.4%. We previously detected IgG antibodies to desmoglein-1 in 97% of patients, but also in 55% of normal subjects in the endemic focus, with progressively lower levels in normal subjects in surrounding areas. An environmental trigger is hypothesized to explain these and other findings. In this study we sought to determine if patients and enzyme-linked-immunosorbent-assay-positive normal subjects in Limao Verde differ in IgG subclass response to desmoglein-1. We developed a sensitive and specific subclass enzyme-linked immunosorbent assay using recombinant desmoglein-1 and standardized the assay to enable comparability between the four subclasses. We found that normal subjects have an IgG1 and IgG4 response, whereas patients have similar levels of IgG1 but a mean 19.3-fold higher IgG4 response. Patients in remission have a weak IgG4 response, and a 74.3-fold higher IgG4 response is associated with active disease. Finally, in five patients in whom we had blood samples from both before and after the onset of clinical disease, a mean 103.08-fold rise in IgG4 was associated with onset of clinical disease, but only a mean 3.45-fold rise in IgG1. These results suggest that the early antibody response in normal subjects living in the endemic area and in patients before the onset of clinical disease is mainly IgG1. Acquisition of an IgG4 response is a key step in the development of clinical disease
First-principles study of the structural energetics of PdTi and PtTi
The structural energetics of PdTi and PtTi have been studied using
first-principles density-functional theory with pseudopotentials and a
plane-wave basis. We predict that in both materials, the experimentally
reported orthorhombic phase will undergo a low-temperature phase
transition to a monoclinic ground state. Within a soft-mode framework,
we relate the structure to the cubic structure, observed at high
temperature, and the structure to via phonon modes strongly
coupled to strain. In contrast to NiTi, the structure is extremely close
to hcp. We draw on the analogy to the bcc-hcp transition to suggest likely
transition mechanisms in the present case.Comment: 8 pages 5 figure
quasiharmonic equations of state for dynamically-stabilized soft-mode materials
We introduce a method for treating soft modes within the analytical framework
of the quasiharmonic equation of state. The corresponding double-well
energy-displacement relation is fitted to a functional form that is harmonic in
both the low- and high-energy limits. Using density-functional calculations and
statistical physics, we apply the quasiharmonic methodology to solid periclase.
We predict the existence of a B1--B2 phase transition at high pressures and
temperatures
Influence of Salt on the Solution Dynamics of a Phosphorylcholine-Based Polyzwitterion
The diffusion of a polyzwitterion, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), in aqueous solution containing different alkali halides was studied by fluorescence correlation spectroscopy at single molecule level. It was found that the halide anion has a greater effect on the radius of zwitterionic PMPC molecules than alkali cations, which is due to the mechanism by which PMPC molecules interact with the surrounding hydrogen bond network of water molecules and adsorbed ions. With the addition of salt, the size of PMPC remains constant while its diffusion coefficient is reduced slightly, although larger cations (e.g. K+) result in slightly increased diffusion coefficient for 1 M potassium chloride-based solutions. This enhanced diffusion coefficient is attributed to the decrease in the viscosity of the aqueous solution on the addition of salt. When the counter-ion was varied in potassium-based salts, different effects were observed for different anions, resulting a reduction in the diffusion coefficient as a function of salt concentration. This reduction was modest for KBr, but significant for KI. Overall, no discernible changes were observed as the size of the PMPC coil was varied, except in case of KI for which a significant increase was observed at higher ionic strength. Divalent cations (Ca2+ and Mg2+), produced similar effects to those found for monovalent cations. These effects are explained by the interaction of PMPC with the hydrogen bond network of water molecules and with the adsorbed ions
Extragalactic neutrino background from very young pulsars surrounded by supernova envelopes
We estimate the extragalactic muon neutrino background which is produced by
hadrons injected by very young pulsars at an early phase after supernova
explosion. It is assumed that hadrons are accelerated in the pulsar wind zone
which is filled with thermal photons captured below the expanding supernova
envelope. In collisions with those thermal photons hadrons produce pions which
decay into muon neutrinos. At a later time, muon neutrinos are also produced by
the hadrons in collisions with matter of the expanding envelope. We show that
extragalactic neutrino background predicted by such a model should be
detectable by the planned 1 km neutrino detector if a significant part of
pulsars is born with periods shorter than ms. Since such population
of pulsars is postulated by the recent models of production of extremely high
energy cosmic rays, detection of neutrinos with predicted fluxes can be used as
their observational test.Comment: 4 pages, 2 figures, A&A style, accepted to A&A Let
Isotropic-nematic phase equilibria in the Onsager theory of hard rods with length polydispersity
We analyse the effect of a continuous spread of particle lengths on the phase
behavior of rodlike particles, using the Onsager theory of hard rods. Our aim
is to establish whether ``unusual'' effects such as isotropic-nematic-nematic
(I-N-N) phase separation can occur even for length distributions with a single
peak. We focus on the onset of I-N coexistence. For a log-normal distribution
we find that a finite upper cutoff on rod lengths is required to make this
problem well-posed. The cloud curve, which tracks the density at the onset of
I-N coexistence as a function of the width of the length distribution, exhibits
a kink; this demonstrates that the phase diagram must contain a three-phase
I-N-N region.
Theoretical analysis shows that in the limit of large cutoff the cloud point
density actually converges to zero, so that phase separation results at any
nonzero density; this conclusion applies to all length distributions with
fatter-than-exponentail tails. Finally we consider the case of a Schulz
distribution, with its exponential tail. Surprisingly, even here the long rods
(and hence the cutoff) can dominate the phase behaviour, and a kink in the
cloud curve and I-N-N coexistence again result. Theory establishes that there
is a nonzero threshold for the width of the length distribution above which
these long rod effects occur, and shows that the cloud and shadow curves
approach nonzero limits for large cutoff, both in good agreement with the
numerical results.Comment: 20 pages, 13 figure
Multi-stakeholder consensus on a target product profile for an HIV cure
Developing a cure for HIV is a global priority. Target product profiles are a tool commonly used throughout the drug development process to align interested parties around a clear set of goals or requirements for a potential product. Three distinct therapeutic modalities (combination therapies, ex-vivo gene therapy, and in-vivo gene therapy) for a target product profile for an HIV cure were identified. Using a process of expert face-to-face consultation and an online Delphi consultation, we found a high degree of agreement regarding the criteria for the optimum target product profile. Although the minimum attributes for a cure were debated, the broad consensus was that an acceptable cure need not be as safe and effective as optimally delivered antiretroviral therapy. An intervention that successfully cured a reasonable fraction of adults would be sufficient to advance to the clinic. These target product profiles will require further discussion and ongoing revisions as the field matures
Charged pion form factor between Q^2=0.60 and 2.45 GeV^2. II. Determination of, and results for, the pion form factor
The charged pion form factor, Fpi(Q^2), is an important quantity which can be
used to advance our knowledge of hadronic structure. However, the extraction of
Fpi from data requires a model of the 1H(e,e'pi+)n reaction, and thus is
inherently model dependent. Therefore, a detailed description of the extraction
of the charged pion form factor from electroproduction data obtained recently
at Jefferson Lab is presented, with particular focus given to the dominant
uncertainties in this procedure. Results for Fpi are presented for
Q^2=0.60-2.45 GeV^2. Above Q^2=1.5 GeV^2, the Fpi values are systematically
below the monopole parameterization that describes the low Q^2 data used to
determine the pion charge radius. The pion form factor can be calculated in a
wide variety of theoretical approaches, and the experimental results are
compared to a number of calculations. This comparison is helpful in
understanding the role of soft versus hard contributions to hadronic structure
in the intermediate Q^2 regime.Comment: 18 pages, 11 figure
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