Controlled surface initiated polymerization of N-isopropylacrylamide from polycaprolactone substrates for regulating cell attachment and detachment

Poly(ε-caprolactone) (PCL) substrates were modified with thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) brushes to direct and control cellular attachment and detachment. Prior to brush growth, the surface of PCL was activated by a diamine to allow for initiator coupling. Infrared spectra taken before and after cell culturing demonstrated the covalently attached nature of the PNIPAM brushes. PCL is a biocompatible polymer and to prove that the modifications described above did not change this characteristic property, a cell attachment/detachment study was carried out. The modified substrates showed a lower cell attachment when compared to PCL alone and to PCL films modified with the initiator. The possibility to detach the cells in the form of a sheet was proved using PNIPAM-modified PCL films by lowering the temperature to 25 °C. No relevant detachment was shown by the unmodified or by the initiator modified surfaces. This confirmed that the detachment was temperature dependent and not connected to other factors such as polymer swelling. These functionalized polymeric films can find applications as smart cell culture systems in regenerative medicine applications

Utilising Emotion Monitoring for Developing Music Interventions for People with Dementia:A State-of-the-Art Review

The demand for smart solutions to support people with dementia (PwD) is increasing. These solutions are expected to assist PwD with their emotional, physical, and social well-being. At the moment, state-of-the-art works allow for the monitoring of physical well-being; however, not much attention is delineated for monitoring the emotional and social well-being of PwD. Research on emotion monitoring can be combined with research on the effects of music on PwD given its promising effects. More specifically, knowledge of the emotional state allows for music intervention to alleviate negative emotions by eliciting positive emotions in PwD. In this direction, the paper conducts a state-of-the-art review on two aspects: (i) the effect of music on PwD and (ii) both wearable and non-wearable sensing systems for emotional state monitoring. After outlining the application of musical interventions for PwD, including emotion monitoring sensors and algorithms, multiple challenges are identified. The main findings include a need for rigorous research approaches for the development of adaptable solutions that can tackle dynamic changes caused by the diminishing cognitive abilities of PwD with a focus on privacy and adoption aspects. By addressing these requirements, advancements can be made in harnessing music and emotion monitoring for PwD, thereby facilitating the creation of more resilient and scalable solutions to aid caregivers and PwD

Sequential Monte Carlo simulation of collision risk in free flight air traffic

Within HYBRIDGE a novel approach in speeding up Monte Carlo simulation of rare events has been developed. In the current report this method is extended for application to simulating collisions with a stochastic dynamical model of an air traffic operational concept. Subsequently this extended Monte Carlo simulation approach is applied to a simulation model of an advanced free flight operational concept; i.e. one in which aircraft are responsible for self separation with each other. The Monte Carlo simulation results obtained for this advanced concept show that the novel method works well, and that it allows studying rare events that stayed invisible in previous Monte Carlo simulations of advanced air traffic operational concepts

Performance of a Non-Local Van der Waals Density Functional on the Dissociation of H2 on Metal Surfaces

Theoretical Chemistr

Interchange Slip-Running Reconnection and Sweeping SEP Beams

We present a new model to explain how particles (solar energetic particles; SEPs), accelerated at a reconnection site that is not magnetically connected to the Earth, could eventually propagate along the well-connected open flux tube. Our model is based on the results of a low-beta resistive magnetohydrodynamics simulation of a three-dimensional line-tied and initially current-free bipole, that is embedded in a non-uniform open potential field. The topology of this configuration is that of an asymmetric coronal null-point, with a closed fan surface and an open outer spine. When driven by slow photospheric shearing motions, field lines, initially fully anchored below the fan dome, reconnect at the null point, and jump to the open magnetic domain. This is the standard interchange mode as sketched and calculated in 2D. The key result in 3D is that, reconnected open field lines located in the vicinity of the outer spine, keep reconnecting continuously, across an open quasi-separatrix layer, as previously identified for non-open-null-point reconnection. The apparent slipping motion of these field lines leads to form an extended narrow magnetic flux tube at high altitude. Because of the slip-running reconnection, we conjecture that if energetic particles would be traveling through, or be accelerated inside, the diffusion region, they would be successively injected along continuously reconnecting field lines that are connected farther and farther from the spine. At the scale of the full Sun, owing to the super-radial expansion of field lines below 3 solar radii, such energetic particles could easily be injected in field lines slipping over significant distances, and could eventually reach the distant flux tube that is well-connected to the Earth

Modelling of Multi-Agent Systems: Experiences with Membrane Computing and Future Challenges

Formal modelling of Multi-Agent Systems (MAS) is a challenging task due to high complexity, interaction, parallelism and continuous change of roles and organisation between agents. In this paper we record our research experience on formal modelling of MAS. We review our research throughout the last decade, by describing the problems we have encountered and the decisions we have made towards resolving them and providing solutions. Much of this work involved membrane computing and classes of P Systems, such as Tissue and Population P Systems, targeted to the modelling of MAS whose dynamic structure is a prominent characteristic. More particularly, social insects (such as colonies of ants, bees, etc.), biology inspired swarms and systems with emergent behaviour are indicative examples for which we developed formal MAS models. Here, we aim to review our work and disseminate our findings to fellow researchers who might face similar challenges and, furthermore, to discuss important issues for advancing research on the application of membrane computing in MAS modelling.Comment: In Proceedings AMCA-POP 2010, arXiv:1008.314

A burst with double radio spectrum observed up to 212 GHz

We study a solar flare that occurred on September 10, 2002, in active region NOAA 10105 starting around 14:52 UT and lasting approximately 5 minutes in the radio range. The event was classified as M2.9 in X-rays and 1N in H\alpha. Solar Submillimeter Telescope observations, in addition to microwave data give us a good spectral coverage between 1.415 and 212 GHz. We combine these data with ultraviolet images, hard and soft X-rays observations and full-disk magnetograms. Images obtained from Ramaty High Energy Solar Spectroscopic Imaging data are used to identify the locations of X-ray sources at different energies and to determine the X-ray spectrum, while ultra violet images allow us to characterize the coronal flaring region. The magnetic field evolution of the active region is analyzed using Michelson Doppler Imager magnetograms. The burst is detected at all available radio-frequencies. X-ray images (between 12 keV and 300 keV) reveal two compact sources and 212 GHz data, used to estimate the radio source position, show a single compact source displaced by 25" from one of the hard X-ray footpoints. We model the radio spectra using two homogeneous sources, and combine this analysis with that of hard X-rays to understand the dynamics of the particles. Relativistic particles, observed at radio wavelengths above 50 GHz, have an electron index evolving with the typical soft-hard-soft behaviour.Comment: Submitted to Solar Physics, 20 pages, 8 fugure