CosmoQuest: Better Citizen Science Through Education

In the modern era, NASA SMD missions and facilities are producing data at a rate too great for the science community to maximally utilize. While software can help, what is really needed is additional eyes, hands, and minds - help we can find in the form of citizen scientist volunteers. The CosmoQuest virtual research facility has demonstrated through published research results that classroom students and the public can, with proper training and support from Subject Matter Experts (SMEs), fill roles more traditionally filled by university students. The research question behind CosmoQuest's creation was simple: if students and the public are provided a properly scaffolded experience that mirrors that of researchers, will they come and perform as well as our students? and can they rise up to be research collaborators? In creating CosmoQuest, we started with a core of citizen science portals, educational materials for both students and life-long learners, and collaboration areas. These three primary focuses mirror the research, courses, and collaboration spaces that form the foundation of a university department. We then went on to add the features that make a center stand out - we added seminars in the form of Google Hangouts on Air, planetarium content through our Science on the Half Sphere program, and even the chance to vicariously attend conferences through live blogging by our team members. With this design for a virtual research facility, the answer to our foundational question has been a resounding yes; the public can aid us in doing science provided they are properly trained. To meet the needs of our population we have developed four areas of engagement: research, education, media, and community

Pharmacologic Inhibition of the TGF-β Type I Receptor Kinase Has Anabolic and Anti-Catabolic Effects on Bone

During development, growth factors and hormones cooperate to establish the unique sizes, shapes and material properties of individual bones. Among these, TGF-β has been shown to developmentally regulate bone mass and bone matrix properties. However, the mechanisms that control postnatal skeletal integrity in a dynamic biological and mechanical environment are distinct from those that regulate bone development. In addition, despite advances in understanding the roles of TGF-β signaling in osteoblasts and osteoclasts, the net effects of altered postnatal TGF-β signaling on bone remain unclear. To examine the role of TGF-β in the maintenance of the postnatal skeleton, we evaluated the effects of pharmacological inhibition of the TGF-β type I receptor (TβRI) kinase on bone mass, architecture and material properties. Inhibition of TβRI function increased bone mass and multiple aspects of bone quality, including trabecular bone architecture and macro-mechanical behavior of vertebral bone. TβRI inhibitors achieved these effects by increasing osteoblast differentiation and bone formation, while reducing osteoclast differentiation and bone resorption. Furthermore, they induced the expression of Runx2 and EphB4, which promote osteoblast differentiation, and ephrinB2, which antagonizes osteoclast differentiation. Through these anabolic and anti-catabolic effects, TβRI inhibitors coordinate changes in multiple bone parameters, including bone mass, architecture, matrix mineral concentration and material properties, that collectively increase bone fracture resistance. Therefore, TβRI inhibitors may be effective in treating conditions of skeletal fragility

Geological interpretation of volcanism and segmentation of the Mariana back-arc spreading center between 12.7°N and 18.3°N

The relationships between tectonic processes, magmatism, and hydrothermal venting along ∼600 km of the slow-spreading Mariana back-arc between 12.7°N and 18.3°N reveal a number of similarities and differences compared to slow-spreading mid-ocean ridges. Analysis of the volcanic geomorphology and structure highlights the complexity of the back-arc spreading center. Here, ridge segmentation is controlled by large-scale basement structures that appear to predate back-arc rifting. These structures also control the orientation of the chains of cross-arc volcanoes that characterize this region. Segment-scale faulting is oriented perpendicular to the spreading direction, allowing precise spreading directions to be determined. Four morphologically distinct segment types are identified: dominantly magmatic segments (Type I); magmatic segments currently undergoing tectonic extension (Type II); dominantly tectonic segments (Type III); and tectonic segments currently undergoing magmatic extension (Type IV). Variations in axial morphology (including eruption styles, neovolcanic eruption volumes, and faulting) reflect magma supply, which is locally enhanced by cross-arc volcanism associated with N-S compression along the 16.5°N and 17.0°N segments. In contrast, cross-arc seismicity is associated with N-S extension and increased faulting along the 14.5°N segment, with structures that are interpreted to be oceanic core complexes—the first with high-resolution bathymetry described in an active back-arc basin. Hydrothermal venting associated with recent magmatism has been discovered along all segment types

The molecular logic of endocannabinoid signalling

The endocannabinoids are a family of lipid messengers that engage the cell surface receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana (Cannabis). They are made on demand through cleavage of membrane precursors and are involved in various short-range signalling processes. In the brain, they combine with CB1 cannabinoid receptors on axon terminals to regulate ion channel activity and neurotransmitter release. Their ability to modulate synaptic efficacy has a wide range of functional consequences and provides unique therapeutic possibilities. © 2003, Nature Publishing Group. All rights reserved

Defining the language assessment literacy gap:evidence from a parliamentary inquiry

This study identifies a unique context for exploring lay understandings of language testing, and by extension for characterising the nature of language assessment literacy among non-practitioners, stemming from data in an inquiry into the registration processes and support for overseas trained doctors by the Australian House of Representatives Standing Committee on Health and Ageing. The data come from Hansard transcripts of public hearings of the inquiry. Sections of the data related to language and language testing (as part of the current registration process for doctors seeking employment in Australia) were identified and coded using a thematic analysis. Findings reveal misconceptions about who is responsible for tests and for decisions based on scores in this context, as well as misconceptions about language testing procedures. Issues also emerge concerning the location of expertise in language and language testing. Discussion of these findings contributes to current debate within the language testing community (e.g., Taylor, 2009) about where responsibility lies for increasing language assessment literacy among non-practitioner stakeholders, and how this might best be achieved