Material affective engagements: Examples from ancient Mesopotamia

This is the final version. Available from University of Toronto Libraries via the DOI in this record. This article applies approaches from current emotion research on material affective scaffolds—objects made and used to enhance, and more generally transform, affective states—to the emerging field of study focusing on emotions in ancient Near Eastern societies. Its main goal is to extend the framework of 4E cognition—with its central notion that human cognition is embodied, embedded, enactive, and extended—to the realm of affective states, emphasizing that through our bodily interactions with material objects we transform not just our cognitive processes but also our emotions, moods, and so forth. Thereby, the present study seeks to contribute to the exploration of the relationships between sensory experiences, emotions, moods, and the material world by investigating the affective meanings that material things acquire through people’s entanglements with them. The study focuses on one particular class of objects—Mesopotamian amulets from the first millennium BC, which served as bodily adornments but were also understood to have the power to evoke affective responses through their activation in ritual performances. Referring to scholarly compendia in Mesopotamian cuneiform texts, this study demonstrates that these objects were recommended by healing experts to influence different affective states, both in oneself and others. It examines the connection between affective states and specific material features of the amulet components (consisting of minerals, metals, and plant and animal substances). Finally, Mesopotamian views of affective states and their management are compared with those of contemporary cognitive-affective science. This comparison shows that although there are some analogies, there are also important differences that depend mainly on different understandings of the human mind and agency.Deutsche Forschungsgemeinschaft (DFG)Deutsche Forschungsgemeinschaft (DFG

Opportunities and challenges for using automatic human affect analysis in consumer research

The ability to automatically assess emotional responses via contact-free video recording taps into a rapidly growing market aimed at predicting consumer choices. If consumer attention and engagement are measurable in a reliable and accessible manner, relevant marketing decisions could be informed by objective data. Although significant advances have been made in automatic affect recognition, several practical and theoretical issues remain largely unresolved. These concern the lack of cross-system validation, a historical emphasis of posed over spontaneous expressions, as well as more fundamental issues regarding the weak association between subjective experience and facial expressions. To address these limitations, the present paper argues that extant commercial and free facial expression classifiers should be rigorously validated in cross-system research. Furthermore, academics and practitioners must better leverage fine-grained emotional response dynamics, with stronger emphasis on understanding naturally occurring spontaneous expressions, and in naturalistic choice settings. We posit that applied consumer research might be better situated to examine facial behavior in socio-emotional contexts rather than decontextualized, laboratory studies, and highlight how AHAA can be successfully employed in this context. Also, facial activity should be considered less as a single outcome variable, and more as a starting point for further analyses. Implications of this approach and potential obstacles that need to be overcome are discussed within the context of consumer research

Nitrergic modulation of ion channel function in regulating neuronal excitability

Nitric oxide (NO) signaling in the brain provides a wide range of functional properties in response to neuronal activity. NO exerts its effects through different signaling pathways, namely, through the canonical soluble guanylyl cyclase-mediated cGMP production route and via post-translational protein modifications. The latter pathways comprise cysteine S-nitrosylation and 3-nitrotyrosination of distinct tyrosine residues. Many ion channels are targeted by one or more of these signaling routes, which leads to their functional regulation under physiological conditions or facilities their dysfunction leading to channelopathies in many pathologies. The resulting alterations in ion channel function changes neuronal excitability, synaptic transmission, and action potential propagation. Transient and activity-dependent NO production mediates reversible ion channel modifications via cGMP and S-nitrosylation signaling, whereas more pronounced and longer-term NO production during conditions of elevated oxidative stress leads to increasingly cumulative and irreversible protein 3-nitrotyrosination. The complexity of this regulation and vast variety of target ion channels and their associated functional alterations presents a challenging task in assessing and understanding the role of NO signaling in physiology and disease

Therapeutic combinations and compositions for the treatment of inflammatory bowel disease (II)

The present invention relates to pharmaceutical combinations of at least one TNF inhibitor and riboflavin to treat patients suffering from inflammatory bowel disease (IBD) or other inflammatory conditions (such as rheumatoid arthritis, ankylosing spondylitis, psoriasis, lupus erythematous and multiple sclerosis). This invention also relates to additive and/or combinations of at least one TNF inhibitor and riboflavin. This invention is also related to a method for the treatment or prophylaxis of IBD, which method comprises administering a therapeutically effective amount of TNF inhibitor and riboflavin