Lasso Estimation of an Interval-Valued Multiple Regression Model

A multiple interval-valued linear regression model considering all the cross-relationships between the mids and spreads of the intervals has been introduced recently. A least-squares estimation of the regression parameters has been carried out by transforming a quadratic optimization problem with inequality constraints into a linear complementary problem and using Lemke's algorithm to solve it. Due to the irrelevance of certain cross-relationships, an alternative estimation process, the LASSO (Least Absolut Shrinkage and Selection Operator), is developed. A comparative study showing the differences between the proposed estimators is provided

Control of magnetic domain wall motion in Co microwires by tridimensional e-beam lithographied structures

Resumen del póster presentado al 6th Spanish Workshop in Nanolithography celebrado en Zaragoza (España) del 28 al 30 de octubre de 2014.Work supported by the Spanish MICINN FIS2008-06249 and CSIC JAE Predoc grants.Peer Reviewe

Control strategies for DFIG wind turbines under grid fault conditions

The classical control techniques for regulating the active and reactive power delivery in doubly fed induction generators (DFIG), for wind power applications, are normally based on voltage oriented control (VOC) strategies. Among these algorithms, those that work in a synchronous reference frame, attached to the magnetic flux vector, became very popular. In spite of the good behaviour of such algorithms their performance depends highly on an accurate detection of the stator flux position, something that can be critical under unbalanced or distorted grid voltage conditions. This paper presents a new VOC strategy able to control the operation of a DFIG in the αβ reference frame, with no need of flux position estimation, something that conducts to a more simple and robust algorithm. In order to evaluate the advantages of this new control proposal, namely VOC-RRF, their performance will be compared with the response obtained with a classical VOC algorithm by means of PSCAD/EMTDC® simulation models.Peer ReviewedPostprint (published version

Alfalfa but not milk in lamb's diet improves meat fatty acid profile and a-tocopherol content

To establish animal feeding recommendations, it is required to quantify whether the effects of combining dietary alfalfa and milk on meat composition of light lambs are overlapped or independent. This experiment aimed to evaluate the separate effects of dietary alfalfa and milk access on the light lamb carcass quality (10–11 kg), meat colour, chemical composition, fatty acid profile and a-tocopherol content. Thirty-two lambs were assigned to one of four treatments in a 2 × 2 factorial design. The factors were the inclusion of dietary forage (grazed alfalfa vs. concentrate-fed indoors) and lactation length (weaning at a target live-weight of 13 kg vs. suckling until slaughter at 22–24 kg). Dietary alfalfa but not milk supply improved conjugated linoleic acid isomers (CLA), omega-3 fatty acids and a-tocopherol contents in lamb meat without affecting meat colour attributes. Milk supply affected more the fatty acid profile (more saturated) than the a-tocopherol content of meat. Thus, dietary alfalfa improved CLA, omega-3 fatty acids and a-tocopherol content in light lamb without affecting the meat colour, whereas lengthening the lactation period did not provide benefits in terms of meat colour or healthy nutrient composition

Deseo y actividad sexual en hombres y mujeres mayores

Considering that, aging is associated with changes that could significantly affect sexuality, and that individuals over 65 years are a group of great sexual heterogeneity, the main purpose of this work is to explore the differences between older men and women in terms of sexual desire, activity, and practices. This study was carried out through a questionnaire survey in order to analyse the differences between the men and women in terms of sexual activity during the past year, sexual desire and practices. Results show us that sexual activity in general, and the type of sexual practice in particular, as well as the frequency of such practices, reflect relevant differences between older women and men. Specifically, results of this work reveal that there are men who acknowledge a greater concern about the decrease in frequency of sexual practices; however, a significantly more pronounced decrease in the frequency of these practices in the past year occurs among women. Although there may be significant differences in some specific sexual practices and in the level of sexual desire and impulse between men and women, a significant number of men and women are sexually active throughout their old ageConsiderando que la edad está asociada con cambios que podrían afectar significativamente a la sexualidad, y que los individuos de más de 65 años son un grupo de importante heterogeneidad sexual, el propósito de este trabajo es observar las diferencias entre hombres y mujeres mayores en términos de deseo, prácticas y actividad sexual. Este estudio se llevó a cabo mediante la implementación de un cuestionario para analizar las diferencias entre mujeres y hombres mayores de 65 años en base a su actividad, deseo y prácticas sexuales en el último año. Los resultados muestran que la actividad sexual en general y el tipo de práctica sexual en particular, así como la frecuencia de dichas prácticas, reflejan diferencias relevantes entre mujeres y hombres mayores. Específicamente, los resultados de este trabajo revelan que hay hombres que reconocen una mayor preocupación por el descenso en la frecuencia de las prácticas sexuales; sin embargo, es entre las mujeres donde se produce un mayor descenso en la frecuencia de estas prácticas durante el último año. Aunque parecen existir diferencias significativas en algunas prácticas sexuales específicas y en el nivel de deseo sexual entre hombres y mujeres, un número significativo de hombres y mujeres son sexualmente activos durante su vejezS

The orienteering: Inclusion and sensitization from a cooperative experience

La orientación es una herramienta formativa en-caminada al desarrollo de la persona en todas sus facetas. Entre esos factores que desarrollamos están el trabajo en equipo, la empatía con el com-pañero y el fomento, a través de este tipo de acti-vidades en el medio natural, de la inclusión de per-sonas con diversidad funcional buscando un disfru-te compartido. Esto nos lleva a plantear en este taller que presentamos una propuesta de sensibili-zación, a través de la orientación, hacia las perso-nas con ceguera o deficiencia visual. La metodolo-gía más ajustada, a la propuesta sensibilizadora, es la pedagogía de la aventura, que permite la interio-rización de las experiencias desde la emoción y la reflexión de las actividades. Los contenidos que setratarán en el desarrollo del taller serán los diferen-tes sistemas de referencia, la elaboración e inter-pretación de mapas, la elección de rutas y rumbos, limitando en los participantes el sentido de la vista en alguno de los momentos de aprendizaje de la sesión. En las actividades que se plantearán, los participantes deberán resolver diferentes retos cooperativos con la ayuda de los compañeros de actividad. Entre los materiales que se utilizarán para llevar a cabo el taller estarán diferentes ele-mentos de simulación de las deficiencias visuales, mapas táctiles tridimensionales, mapas táctiles, balizas y hojas de control sensoriales. La orienta-ción dirigida a la sensibilización para la discapaci-dad visual cobra su sentido como propuesta que nos acerca a la inclusión de cualquier participanteen las actividades en el medio natural y a la refle-xión que las limitaciones y posibilidades de partici-pación, en muchos casos, está en la mano todosOrientation is a formative tool aimed at the devel-opment of the person in all its facets. Among thosefactors we develop are teamwork, empathy with the partner and the promotion, through these types of activities in the natural environment, of the inclu-sion of people with functional diversity seeking a shared enjoyment. This leads us to raise in this workshop that we present a proposal to raise awareness, through guidance, to people with blind-ness or visual impairment. The most accurate meth-odology, the sensitizing proposal, is the pedagogy of adventure, which allows the internalization of the experiences from the emotion and the reflection of the activities. The contents that will be treated in the development of the workshop will be the differ-ent systems of reference, the elaboration and inter-pretation of maps, the choice of routes and courses, limiting in the participants the sense of sight in some of the moments of learning of the session. In the activities that will be considered, the partici-pants will have to solve different cooperative chal-lenges with the help of the companions of activity.Among the materials that will be used to carry out the workshop will be different elements of simula-tion of visual deficiencies, three-dimensional tactile maps, tactile maps, beacons and sensory control sheets. The orientation directed at the sensitization for visual impairment, takes its meaning as a pro-posal that brings us closer to the inclusion of any articipant in the activities in the natural environ-ment and to the reflection that the limitations andpossibilities of participation in many cases is in the hands of all

Care of peripheral intravenous catheters in three hospitals in Spain: Mapping clinical outcomes and implementation of clinical practice guidelines

BACKGROUND: Peripheral intravenous catheters (PIVCs) are the most widely used invasive devices worldwide. Up to 42% of PIVCs are prematurely removed during intravenous therapy due to failure. To date, there have been few systematic attempts in European hospitals to measure adherence to recommendations to mitigate PIVC failures. AIM: To analyse the clinical outcomes from clinical practice guideline recommendations for PIVC care on different hospital types and environments. METHODS: We conducted an observational study in three hospitals in Spain from December 2017 to April 2018. The adherence to recommendations was monitored via visual inspection in situ evaluations of all PIVCs inserted in adults admitted. Context and clinical characteristics were collected by an evaluation tool, analysing data descriptively. RESULTS: 646 PIVCs inserted in 624 patients were monitored, which only 52.7% knew about their PIVC. Regarding PIVC insertion, 3.4% (22/646) patients had at least 2 PIVCs simultaneously. The majority of PIVCs were 20G (319/646; 49.4%) and were secured with transparent polyurethane dressing (605/646; 93.7%). Most PIVCs (357/646; 55.3%) had a free insertion site during the visual inspection at first sight. We identified 342/646 (53%) transparent dressings in optimal conditions (clean, dry, and intact dressing). PIVC dressings in medical wards were much more likely to be in intact conditions than those in surgical wards (234/399, 58.7% vs. 108/247, 43.7%). We identified 55/646 (8.5%) PIVCs without infusion in the last 24 hours and 58/646 (9.0%) PIVCs without infusion for more than 24 hours. Regarding PIVC failure, 74 (11.5%) adverse events were identified, all of them reflecting clinical manifestation of phlebitis. CONCLUSIONS: Our findings indicate that the clinical outcome indicators from CPG for PIVC care were moderate, highlighting differences between hospital environments and types. Also, we observed that nearly 50% of patients did not know what a PIVC is

A mild neurofibromatosis type 1 phenotype produced by the combination of the benign nature of a leaky NF1-splice mutation and the presence of a complex mosaicism

Here we analyze the genetic and molecular basis responsible for a very benign phenotype observed in an NF1 patient. Quantification of cells carrying the NF1 mutation in different samples derived from the three embryonic layers revealed mosaicism. Furthermore, the construction of a minigene with patient's mutation (c.3198 − 314G>A) confirmed its benign nature due to the leakiness of the splicing mechanism that generated a proportion of correctly spliced transcripts. Hence, we concluded that the mild phenotype observed in this patient is the result of the presence of mosaicism together with the benign nature of a leaky NF1-splice mutation. Finally, with the aim of developing a personalized therapeutic approach for this patient, we demonstrated correction of the splicing defect by using specific antisense morpholino oligomers. Our results provide an example of the molecular complexity behind disease phenotypes and highlight the importance of using comprehensive genetic approaches to better assess phenotype-genotype correlation