2,675 research outputs found
Clinical performance of bleeding risk scores for predicting major and clinically relevant non-major bleeding events in patients receiving warfarin
Background: Oral anticoagulant therapy is associated with an increased risk of hemorrhage, which can be assessed by bleeding risk scores. We evaluated the performance of five validated scores for predicting major and clinically relevant non-major bleeding events in patients receiving warfarin. Methods and results: We conducted an ambispective, single-center cohort study of 321 consecutive patients enrolled in an academic anticoagulation clinic. The following scores were calculated: modified Outpatient Bleeding Risk Index, Contemporary Bleeding Risk Model, HEMORR2HAGES (Hepatic or Renal Disease, Ethanol Abuse, Malignancy, Older Age, Reduced Platelet Count or Function, Re-Bleeding, Hypertension, Anemia, Genetic Factors, Excessive Fall Risk and Stroke), ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation), and HAS-BLED (Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile International Normalized Ratio, Elderly, Drugs/Alcohol). Main outcomes were major bleeding and a composite of major plus clinically relevant non-major bleeding. Incidence rates for all group were 3.8 (95% confidence interval [CI] 2.0-6.4) and 11.9 (95% CI 8.6-16.4) events per 100 patient-years for major bleeding and major plus clinically relevant non-major bleeding, respectively. Agreement among the five scores was low to moderate (Kendall\u27s tau-b coefficients 0.22-0.54). For major bleeding, the c-statistics ranged from 0.606 to 0.735, whereas for major plus clinically relevant non-major bleeding, they ranged from 0.549 to 0.613. For all scores, the 95% CI for the c-statistics crossed 0.5 or was very close. Among high-risk patients, the hazard ratios for major bleeding ranged from 0.90 to 39.01, whereas for major plus clinically relevant non-major bleeding, they ranged from 1.52 to 8.71. For intermediate-risk patients, no score, except the Contemporary Bleeding Risk Model, produced statistically significant hazard ratios. Conclusion: The scores demonstrated poor agreement and low to moderate discriminatory ability. General clinical implementation of these scores cannot be recommended yet. © 2013 International Society on Thrombosis and Haemostasis
Asymmetric exclusion model with several kinds of impurities
We formulate a new integrable asymmetric exclusion process with
kinds of impurities and with hierarchically ordered dynamics.
The model we proposed displays the full spectrum of the simple asymmetric
exclusion model plus new levels. The first excited state belongs to these new
levels and displays unusual scaling exponents. We conjecture that, while the
simple asymmetric exclusion process without impurities belongs to the KPZ
universality class with dynamical exponent 3/2, our model has a scaling
exponent . In order to check the conjecture, we solve numerically the
Bethe equation with N=3 and N=4 for the totally asymmetric diffusion and found
the dynamical exponents 7/2 and 9/2 in these cases.Comment: to appear in JSTA
The Bethe ansatz as a matrix product ansatz
The Bethe ansatz in its several formulations is the common tool for the exact
solution of one dimensional quantum Hamiltonians. This ansatz asserts that the
several eigenfunctions of the Hamiltonians are given in terms of a sum of
permutations of plane waves. We present results that induce us to expect that,
alternatively, the eigenfunctions of all the exact integrable quantum chains
can also be expressed by a matrix product ansatz. In this ansatz the several
components of the eigenfunctions are obtained through the algebraic properties
of properly defined matrices. This ansatz allows an unified formulation of
several exact integrable Hamiltonians. We show how to formulate this ansatz for
a huge family of quantum chains like the anisotropic Heisenberg model,
Fateev-Zamolodchikov model, Izergin-Korepin model, model, Hubbard model,
etc.Comment: 4 pages and no figure
Exactly solvable interacting vertex models
We introduce and solvev a special family of integrable interacting vertex
models that generalizes the well known six-vertex model. In addition to the
usual nearest-neighbor interactions among the vertices, there exist extra
hard-core interactions among pair of vertices at larger distances.The
associated row-to-row transfer matrices are diagonalized by using the recently
introduced matrix product {\it ansatz}. Similarly as the relation of the
six-vertex model with the XXZ quantum chain, the row-to-row transfer matrices
of these new models are also the generating functions of an infinite set of
commuting conserved charges. Among these charges we identify the integrable
generalization of the XXZ chain that contains hard-core exclusion interactions
among the spins. These quantum chains already appeared in the literature. The
present paper explains their integrability.Comment: 20 pages, 3 figure
The Dynamical Behaviour of Test Particles in a Quasi-Spherical Spacetime and the Physical Meaning of Superenergy
We calculate the instantaneous proper radial acceleration of test particles
(as measured by a locally defined Lorentzian observer) in a Weyl spacetime,
close to the horizon. As expected from the Israel theorem, there appear some
bifurcations with respect to the spherically symmetric case (Schwarzschild),
which are explained in terms of the behaviour of the superenergy, bringing out
the physical relevance of this quantity in the study of general relativistic
systems.Comment: 14 pages, Latex. 4 figures. New references added. Typos corrected. To
appear in Int. J. Theor. Phy
Magnon delocalization in ferromagnetic chains with long-range correlated disorder
We study one-magnon excitations in a random ferromagnetic Heisenberg chain
with long-range correlations in the coupling constant distribution. By
employing an exact diagonalization procedure, we compute the localization
length of all one-magnon states within the band of allowed energies . The
random distribution of coupling constants was assumed to have a power spectrum
decaying as . We found that for ,
one-magnon excitations remain exponentially localized with the localization
length diverging as 1/E. For a faster divergence of is
obtained. For any , a phase of delocalized magnons emerges at the
bottom of the band. We characterize the scaling behavior of the localization
length on all regimes and relate it with the scaling properties of the
long-range correlated exchange coupling distribution.Comment: 7 Pages, 5 figures, to appear in Phys. Rev.
Estado del arte de la quinua en el mundo en 2013
Alimento de base de las poblaciones andinas desde hace milenios, la quinua se ha convertido hoy en un producto apreciado en el mercado internacional de alimentos dietéticos, orgánicos y equitativos. Este cambio lo iniciaron los mismos productores del Altiplano Sur de Bolivia hace aproximadamente unos 40 años. En medio de un desierto de altura, ellos lograron desarrollar una floreciente producción agrícola de exportación. Aunque cuentan con lucrativos nichos de mercado, los productores de quinua no son agricultores especializados, ni residen de forma permanente en la zona de producción. Estas son algunas de las paradojas que caracterizan la producción de quinua en el Altiplano Sur de Bolivia. Después de describir el origen, la diversidad y los rasgos biológicos del ecotipo Quinua Real en el cual se basa la producción de esta zona, se plantea la importancia de la quinua en los agrosistemas locales y, más allá, en los sistemas de actividades agrícolas y no agrícolas manejados por las familias del Altiplano Sur. Movilidad geográfica y pluriactividad forman parte del modo de vida ancestral de estas poblaciones y determinan hasta hoy en día las condiciones de uso de los recursos territoriales y la organización de los productores en el contexto del auge comercial de la quinua. La producción actual de quinua en la región presenta rasgos de vulnerabilidad agroecológica y social, así como capacidades adaptativas para enfrentarlos. Se resaltan como puntos clave para la sostenibilidad de los agrosistemas locales : i) la concertación de reglas comunales e individuales para el acceso y uso de la tierra en agrosistemas socialmente equitativos y equilibrados entre cultivo y ganadería, ii) las normas internacionales para el reconocimiento de la Quinua Real en los mercados de exportación, iii) una actualización continua de las reglas y normas para mantener la adaptabilidad de los agrosistemas locales a los cambios imprevisibles del contexto socio-ecológico a varias escalas de espacio y de tiempo
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A Search for Dark Higgs Bosons
Recent astrophysical and terrestrial experiments have motivated the proposal
of a dark sector with GeV-scale gauge boson force carriers and new Higgs
bosons. We present a search for a dark Higgs boson using 516 fb-1 of data
collected with the BABAR detector. We do not observe a significant signal and
we set 90% confidence level upper limits on the product of the Standard
Model-dark sector mixing angle and the dark sector coupling constant.Comment: 7 pages, 5 postscript figures, published version with improved plots
for b/w printin
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