Bialy L.

Boutros R.

Brezak M. C.

Brisson M.

Buhrman G.

Cao S.

Cho S. H.

Contour-Galcera M. O.

Hirai G.

Kar S.

Kristjánsdóttir K.

Lazo J. S.

Lyon M. A.

Malumbres M.

Mineo C.

Pu L.

Rahmouni S.

Sodeoka M.

Th'ng J. P. H

Zhou Y. B.

English

PubMed

Ayako Tsuchiya

Go Hirai

Yusuke Koyama

Kana Oonuma

Yuko Otani

Hiroyuki Osada

Mikiko Sodeoka

Crossref

ACS Medicinal Chemistry Letters

Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure

CDC25 phosphatases and cancer.

CDC25 phosphatases in cancer cells: Key players? Good targets?

Cell cycle, CDKs and cancer: a changing paradigm.

Development of a Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure. ChemMedChem

Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase CDC25.

Dual G1 and G2 phase inhibition by a novel, selective CDC25 inhibitor 6-chloro-7-(2-morpholin-4-ylethylamino)quinoline-5,8-dione.

Dual-specificity phosphatases as targets for antineoplastic agents.

H32, a non-quinone sulfone analog of vitamin K3, inhibits human hepatoma cell growth by inhibiting CDC25 and activating

Halenaquinone and xestoquinone derivatives, inhibitors of CDC25B phosphatase from a Xestospongia sp.

Identification of a potent and selective pharmacophore for CDC25 dual specificity phosphatase inhibitors.

Inhibitors of protein tyrosine phosphatases: Next-generation drugs?

IRC-083864, a novel bis quinone inhibitor of CDC25 phosphatases active against human cancer cells.

Isolation and analysis of a mammalian temperature-sensitive mutant defective in G2 functions. Exp. Cell Res.

LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation. Acta Pharmacol.

Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and

Redox regulation of CDC25B by cell-active quinolinediones.

Redox regulation of PTEN and protein tyrosine phosphatases in H2O2 mediated cell signaling. FEBS Lett.

See the Supporting Information.

Structural mechanism of oxidative regulation of the phosphatase CDC25B via an intramolecular disulfide bond. Biochemistry

Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and CDC25B inhibition.

The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product. Cell

The inhibitory activity of 10d against CDC25B in the presence of surfactants is discussed in the Supporting Information.

W i l c o x ,C .S . ;C a r r ,B .I .B i n d i n ga n di n h i b i t i o no fC

What's new on CDC25 phosphatase inhibitors.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3324983

Dual-Specificity Phosphatase
CDC25A/B Inhibitor Identified
from a Focused Library with Nonelectrophilic Core Structure

Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure

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