A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial

Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in 'real-world' services

Studio di microzonazione sismica di dettaglio dell’area del comune di Mirabello (FE) basata sull’interpolazione tridimensionale di dati geologici e geofisici puntuali.

La pubblicazione risulta metodologie e risultati di uno studio di microzonazione sismica di dettaglio dell’area del comune di Mirabello (FE), basato sull’interpolazione tridimensionale di dati geologici e geofisici puntuali, mediante tecniche geomatiche, che integrano dati stratigrafico-sedimentologici, geotecnici e geofisici

Studio di microzonazione sismica di dettaglio dell’area del Comune di Mirabello (Ferrara) basata sull’interpolazione di dati geologici e geofisici puntuali.

The contribution describes the high resolution seismic hazard evaluation in an area severely affected by the seismic event the 20th may 2012. Surface geological mapping and reconstruction of the geophysical properties of the underground stratigraphic bodies were integrated with geotechnical evaluation of cone penetration tests to evaluate the site features affecting the seismic damage, such as amplification and liquefaction phenomena

Immune and metabolic alterations in first episode psychosis (FEP) patients

The molecular underpinnings associated to first episode psychosis (FEP) remains to be elucidated, but compelling evidence supported an association of FEP with blood alterations in biomarkers related to immune system, growth factors and metabolism regulators. Many of these studies have not been already confirmed in larger samples or have not considered the FEP diagnostic subgroups. In order to identify biochemical signatures of FEP, the serum levels of the growth factors BDNF and VEGF, the immune regulators IL-1RA, IL-6, IL-10 and IL-17, RANTES/CCL5, MIP-1b/CCL4, IL-8 and the metabolic regulators C-peptide, ghrelin, GIP, GLP-1, glucagon, insulin, leptin, PAI-1, resistin and visfatin were analysed in 260 subjects collected in the GET UP project. The results indicated an increase of MIP-1b/CCL4, VEGF, IL-6 and PAI-1, while IL-17, ghrelin, glucagon and GLP-1 were decreased in the whole sample of FEP patients (p\u202f<\u202f0.01 for all markers except for PAI-1 p\u202f<\u202f0.05). No differences were evidenced for these markers among the diagnostic groups that constitute the FEP sample, whereas IL-8 is increased only in patients with a diagnosis of affective psychosis. The principal component analysis (PCA) and variable importance analysis (VIA) indicated that MIP-1b/CCL4, ghrelin, glucagon, VEGF and GLP-1 were the variables mostly altered in FEP patients. On the contrary, none of the analysed markers nor a combination of them can discriminate between FEP diagnostic subgroups. These data evidence a profile of immune and metabolic alterations in FEP patients, providing new information on the molecular mechanism associated to the psychosis onset for the development of preventive strategies and innovative treatment targets