Pharmacokinetics studying fenibut in experiment at pregnancy

Purpose: To spend an estimation of parities between the maintenance fenibut in plasma of blood and a brain of rats and its maintenance in a placenta and an organism of embryos of rats.Materials and Methods: Experimental researches are spent on 124 pregnant females of rats. The preparation was entered in a stomach, unitary in doses of weight of an animal by of 100 and 200 mg/kg. Through 5, 10, 20, 40 mines, 1 h 20 min, 2 h 40 min., 6 and 12 hours after preparation introduction took samples of blood, a brain, a placenta, an embryos and waters about an embryo.Results: The maximum concentration fenibut in all bodies and fabrics is reached on 40 minute, then throughout 6 hours stable level of a preparation with constant smooth decrease is observed that quite arranges obstetrics clinic as in the course of regulation of the patrimonial certificate are especially important stability, duration and absence of sharp jumps in concentration of a preparation.Summary: The preparation greatest quantity concentrates in the basic body of the appendix – a brain. The least quantity fenibut gets to an embryo. The obtained data confirms expediency of use fenibut in obstetrics clinic

MADE ULTRASONIC DIAGNOSIS OF FETAL MALFORMATION. REALITY AND PERSPECTIVE

Purpose: Analysis of the identified congenital malformations of the fetus, as well as identifying opportunities for their prenatal diagnosis.Materials and methods: In a medical and social audit, analysis of data, examine the anamnesis approaches for pregnancy, birth, and fetal outcomes among 204 women who gave birth with defects of development. Given the dynamics of growth of malformations for the years 2010-2012 based on the maternity hospital No. 1 of Rostov-on-Don.Results: There were different types of stains. The work is given the structure of the identified defects. Noted that out of 204 women, only 9 (4.41%) during pregnancy, fetal abnormalities have been identified, the remaining 195 (95.59%) patients vices have not been diagnosed. Such defects have been diagnosed as lumbar hernia, abnormalities of the cardiovascular system and intestines. Other malformations, including chromosomal disease, were not identified. UntimelySummary: All this requires on the one hand to improve prenatal diagnosis of fetal malformation, and improving the training of professionals who know fully the methods of ultrasoun

Outcome of Pregnancy and Labour in a Patient with Hodgkin’s Lymphoma (Clinical Case)

Background. Hodgkin’s lymphoma (HL) is a malignant disease of lymphoid tissue, which is characterised by the appearance of giant Reed—Berezovsky—Sternberg cells in the lymph nodes affected by the pathological process. These cells can be detected through microscopic examination. Currently, HL is one of the most treatable oncological diseases. In recent years, the recovery rate in patients suffering from this pathology has increased (70–90%), almost reaching the recovery rate in patients starting treatment at the early stages. Given the above, the quality of life in these patients during remission is becoming more important, since most of them are women of childbearing age planning to have children. In this connection, it is of great importance to study the course of pregnancy and labour, along with their effect on the possibility of a relapse, in such patients.Aim. In this paper, we set out to analyse the course of pregnancy and childbirth in a patient suffering from HL.Materials and methods. We studied the medical records (including medical history and pregnancy records) of a patient whose pregnancy occurred in the setting of a severe oncological pathology – HL in remission. The patient underwent a thorough examination and the baby was successfully delivered.Result. The outcome of pregnancy and childbirth for the patient and foetus was studied in the setting of a severe oncological pathology (HL in remission).Conclusion. The pregnancy of a woman suffering from a serious oncological pathology (HL in remission) was prolonged to full-term and successfully completed. The patient was able to experience the joy of motherhood for the third time

Episiotomy as one of the problems of modern periniology

Objective: to analyze the course of pregnancy, childbirth and indications for mediolateral episiotomy in 439 women.Materials and methods: the comparative analysis of outcomes of Rostov-on-Don in two clinical groups on materials of maternity Department of the state hospital of emergency medical care No. 1 of the city of Rostov-on-Don was carried out. The  first group consisted of 439 women who are in childbirth according to the testimony was made episiotomy. Th e second clinical group consisted of 128 women who had no episiotomy if indicated.Results: the main indications for episiotomy in the fi rst clinical group was: threatened rupture of the perineum in 376 (85,65 %) cases, 41 (9,34 %) v distress of the fetus, at 22 (5,01 %) cases — the weakness of the attempts. In 128 women of the second clinical group, in the absence of an episiotomy, although indications for this operation were, there was a rupture of the perineum of the first and second degree.Conclusions: at the signs of a threatening rupture of the perineum or at the clinic of fetal hypoxia in the second period of labor, the mediolateral episiotomy is justified in modern obstetrics

Ichthyosis as one of the forms of hereditary pathology of fetus and newborn

A retrospective analysis of the course of pregnancy and childbirth during the birth of a child with a congenital pathology «ichthyosis» was carried out. This clinical case is interesting because fetal ichthyosis was not diagnosed during pregnancy, but all the signs of this disease were revealed in the newborn after the birth

The rational conducting of pregnancy and kinds with the immunological conflikt (experience of 35-years work)

Purpose: To estimate efficiency of work of the specialized reception of pregnant with an immunological conflict.Materials and Methods: The analysis of flow of pregnancy is conducted, births, ends for a fruit in 5- ti clinical groups. A dynamic supervision was conducted, a title was determined groups and anti-rezusnykh antibodies, ULTRASONIC, dopplerometriya fruit.Results: In all 21659 children borned in all clinical groups, at the 1377 (6,4%) new-born was GB is diagnosed.Summary: The got results confirmed efficiency of work of the specialized reception, that allowed to reduce morbidity ot gemoliticheskoy illness in 6 times

Dysfunction of the symphysis as one of the actual problems of modern obstetrics

Objective: To analyze the factors of the course and outcome of pregnancy in women with pubic joint dysfunction (DLS).Materials and Methods: Th e authors performed a retrospective analysis of the course of pregnancy and the outcome of childbirth in women with pubic joint dysfunction (DLS) observed in 2016 – 2019. As a result, data on the clinical course of pregnancy and childbirth in 75 women with DLS were obtained. All women underwent routine clinical and biochemical examinations, ultrasound diagnostics (US), dopplerometry (DPM), and cardiotocography (CTG). Th e analysis of all the above parameters was carried out according to the data of birth histories for 2016-2018. Statistical processing of the obtained results was carried out using the programs Statistica 10 and Microsoft Excel 2013.Results: Clinical manifestations, as well as changes in ultrasound data, became the main factor in deciding on the method of delivery. All patients with second-degree DLS delivered by elective Caesarean section at 39 – 40 weeks of gestation. Women with the fi rst degree of DLS had a vaginal birth. Ultrasound examination in the postpartum period did not reveal an increase in the diastasis of the pubic joint in any woman. All the postpartum women had no complications during the postpartum period.Conclusion: DLS is a serious complication, which can lead to serious consequences in some cases in the postpartum period. It may require surgical treatment and subsequent long-term rehabilitation. For early diagnostics of DLS, it may be advisable to conduct a mandatory ultrasonic examination of the pubic joint, which is the “gold standard” for the diagnosis of this pathology, to all patients during screening ultrasonic examination

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe

Effect of SGLT2 inhibitors on stroke and atrial fibrillation in diabetic kidney disease: Results from the CREDENCE trial and meta-analysis

BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-Analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus. METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-Analysis. RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: Total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]). CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe