Specific Absorption Rate of Assembly of Magnetite Nanoparticles with Cubic Magnetic Anisotropy

The presence of strong magnetic dipole interaction in assemblies of fractal clusters of nearly spherical magnetite nanoparticles, which arise in a biological media loaded with magnetic nanoparticles, leads to a significant decrease of the specific absorption rate of these assemblies in alternating magnetic field. However, the specific absorption rate of the assembly can be increased if the nanoparticles are covered by non magnetic shells of sufficiently large thickness comparable with the nanoparticle diameter. Keywords: Magnetite nanoparticles, Magneto- dipole interaction, Specific absorption rate, Numerical simulatio

STATE OF DIAGNOSIS AND TREATMENT OF PATIENTS WITH OVARIAN CANCER IN KRASNODAR KRAI IN 2005-2014

Aim. To study the features of the diagnosis of ovarian cancer in the territory of a large agro-industrial region of Russia – Krasnodar Krai. Materials and methods. Materials for the study were data from the Population Cancer Registry of Krasnodar Krai, as well as the statistical registration form No. 1090/y "Notification of a patient with a first-time diagnosis of cancer or other malignant neoplasm". Based on data on 5 583 newly diagnosed patients with ovarian cancer for the period 2005-2014, in Krasnodar Krai, the analysis of the dynamics of the main indicators of diagnostic quality (morphological verification, stepwise diagnosis, advanced stage of disease, one-year mortality, preventive detection, etc.) taking into consideration the particular qualities of territorial location in the large agro-industrial region of Russia. The analysis of methods of treatment for the patients with ovarian cancer which are subject to special treatment was carried out for the ten-year period. Results. Analysis of the dynamics of the main indicators of the diagnosis of ovarian cancer in Krasnodar Krai for 2005- 2014 showed that the specific gravity of the morphological verification of the diagnosis in 2014 was 88.7% that is 3.1% lower than the average Russian indicator (91.5%). The level of diagnosis of ovarian cancer in the I-II stage increased by 1.5 times and amounted to 33.3% in 2014, with an average Russian indicator of 37.1%. The level of late diagnosis (III-IV stage) was higher than the Russian average by 8.9%. A low level of active diagnosis of ovarian cancer was registered, which was 15.7%, which is 13.2% lower than the Russian average (18.1%). Conclusion. Recommendations are given to practical public health services to improve the quality of medical care for patients with ovarian cancer in Krasnodar Krai

System of legal limitations on state power: in search of criteria

In the presented paper, some questions concerning the system of legal limitations on state power were covered. In the search for universal criteria for limiting power, the evolution of the main theories of such was analyzed in accordance with the chronology of their emergence and subsequent modernization: the limitation on power by another power, self-limitation of state power, the limitation of state power by law and human rights in conjunction with contemporary problems of limiting a state power in a state governed by the rule of law. Based on the results of the study, a conclusion was drawn on the role of law as the main criterion for limiting state power in the context of the legal state paradig

Effect of electron irradiation on vortex dynamics in YBa_2Cu_3O_{7-x} single crystals

We report on drastic change of vortex dynamics with increase of quenched disorder: for rather weak disorder we found a single vortex creep regime, which we attribute to a Bragg-glass phase, while for enhanced disorder we found an increase of both the depinning current and activation energy with magnetic field, which we attribute to entangled vortex phase. We also found that introduction of additional defects always increases the depinning current, but it increases activation energy only for elastic vortex creep, while it decreases activation energy for plastic vortex creep.Comment: 4 pages, 3 figures, submited to Phys. Rev.

Uniparental Genetic Heritage of Belarusians: Encounter of Rare Middle Eastern Matrilineages with a Central European Mitochondrial DNA Pool

Ethnic Belarusians make up more than 80% of the nine and half million people inhabiting the Republic of Belarus. Belarusians together with Ukrainians and Russians represent the East Slavic linguistic group, largest both in numbers and territory, inhabiting East Europe alongside Baltic-, Finno-Permic- and Turkic-speaking people. Till date, only a limited number of low resolution genetic studies have been performed on this population. Therefore, with the phylogeographic analysis of 565 Y-chromosomes and 267 mitochondrial DNAs from six well covered geographic sub-regions of Belarus we strove to complement the existing genetic profile of eastern Europeans. Our results reveal that around 80% of the paternal Belarusian gene pool is composed of R1a, I2a and N1c Y-chromosome haplogroups – a profile which is very similar to the two other eastern European populations – Ukrainians and Russians. The maternal Belarusian gene pool encompasses a full range of West Eurasian haplogroups and agrees well with the genetic structure of central-east European populations. Our data attest that latitudinal gradients characterize the variation of the uniparentally transmitted gene pools of modern Belarusians. In particular, the Y-chromosome reflects movements of people in central-east Europe, starting probably as early as the beginning of the Holocene. Furthermore, the matrilineal legacy of Belarusians retains two rare mitochondrial DNA haplogroups, N1a3 and N3, whose phylogeographies were explored in detail after de novo sequencing of 20 and 13 complete mitogenomes, respectively, from all over Eurasia. Our phylogeographic analyses reveal that two mitochondrial DNA lineages, N3 and N1a3, both of Middle Eastern origin, might mark distinct events of matrilineal gene flow to Europe: during the mid-Holocene period and around the Pleistocene-Holocene transition, respectively

ИНТРАПЕРИТОНЕАЛЬНОЕ ХИМИОПЕРФУЗИОННОЕ ЛЕЧЕНИЕ ДИССЕМИНИРОВАННОГО РАКА ЯИЧНИКА ДИОКСАДЭТОМ В СРАВНЕНИИ С ЦИСПЛАТИНОМ В ЭКСПЕРИМЕНТЕ

Comparative study of antitumor activity of cisplatin and dioxadet in chemoperfusion treatment was carried out on ascitic ovarian cancer model in 172 Vistar female rats. Ovarian cancer was inoculated intraperitoneally at a volume of 0.5 ml per rat with concentration of tumor cells 2×107 / ml. The drugs were administered once in 48 hours after inoculation of ovarian cancer in maximum tolerated doses (MTD). Normothermic intraperitoneal chemoperfusion (IPEC) and hyperthermic intraperitoneal chemoperfusion (HIPEC) were performed with cisplatin or dioxadet at doses that were 5−20 times higher than those for their standard intraperitoneal administration. Antitumor effects of the drugs were estimated in increase of median survival time (MST). In case of IPEC and HIPEC cisplatin increased the MST by 317  % and 183  % (р<0.05) respectively, when dioxadet increased the MST by 244  % and 444  % (р<0.05) respectively compared to the control group of animals that didn’t receive any treatment. HIPEC with dioxadet is the most effective regimen in experimental treatment of advanced ovarian cancer

ВОЗМОЖНОСТИ ЖИДКОСТНОЙ ЦИТОЛОГИИ В ДИАГНОСТИКЕ РАКА МОЧЕВОГО ПУЗЫРЯ

The study included 323 patients (the first group - 150 patients with suspected bladder cancer, the second - 173 patients with bladder cancer after treatment). All patients underwent cytological investigation of washings of bladder using conventional method and liquid cytology. This study presents comparative characteristics of these methods and shows considerable effectiveness of the method of liquid cytology in the diagnosis of bladder cancer and its local recurrence.В исследование  включено 323 человека (первая  группа – 150 пациентов с подозрением на рак мочевого пузыря, вторая – 173 больных раком мочевого пузыря, после проведенного лечения). Всем обследуемым было выполнено цитологическое исследование  промывных вод мочевого пузыря традиционным методом и методом жидкостной цитологии. Дана сравнительная характеристика этих методов исследования и показана значительная эффективность метода жидкостной цитологии в диагностике рака мочевого пузыря и его местных рецидивов

Совершенствование цитологической диагностики рака мочевого пузыря

The paper gives the comparative results of cytological examination of alcohol-induced bladder washouts by liquid-based cytology and conventional cytology in 323 patients, including 150 with suspected bladder cancer (BC) and 173 patients after performed combination or combined treatment for BC. The performed investigation has established that the diagnostic value of liquid-based cytology in diagnosing BC and its local recurrences is 1.3-fold higher than that of conventional cytology.В работе представлены сравнительные результаты цитологического исследования методом жидкостной цитологии и традиционного цитологического исследования спиртовых смывов мочевого пузыря 323 пациентов, 150 из которых были с подозрением на рак мочевого пузыря (РМП) и 173 пациента – после проведенного комплексного или комбинированного лечения по поводу РМП. В результате проведенного исследования установлено, что диагностическая ценность метода жидкостной цитологии в диагностике РМП и его местных рецидивов в 1,3 раза выше традиционного цитологического метода

Species Diversity and Phylogeographical Affinities of the Branchiopoda (Crustacea) of Churchill, Manitoba, Canada

The region of Churchill, Manitoba, contains a wide variety of habitats representative of both the boreal forest and arctic tundra and has been used as a model site for biodiversity studies for nearly seven decades within Canada. Much previous work has been done in Churchill to study the Daphnia pulex species complex in particular, but no study has completed a wide-scale survey on the crustacean species that inhabit Churchill's aquatic ecosystems using molecular markers. We have employed DNA barcoding to study the diversity of the Branchiopoda (Crustacea) in a wide variety of freshwater habitats and to determine the likely origins of the Churchill fauna following the last glaciation. The standard animal barcode marker (COI) was sequenced for 327 specimens, and a 3% divergence threshold was used to delineate potential species. We found 42 provisional and valid branchiopod species from this survey alone, including several cryptic lineages, in comparison with the 25 previously recorded from previous ecological works. Using published sequence data, we explored the phylogeographic affinities of Churchill's branchiopods, finding that the Churchill fauna apparently originated from all directions from multiple glacial refugia (including southern, Beringian, and high arctic regions). Overall, these microcrustaceans are very diverse in Churchill and contain multiple species complexes. The present study introduces among the first sequences for some understudied genera, for which further work is required to delineate species boundaries and develop a more complete understanding of branchiopod diversity over a larger spatial scale