Myomectomy as a pregnancy-preserving option in the carefully selected patient

Objectives: To present the indications for myomectomy during pregnancy and to discuss complications possibly related and unrelated to the procedure. Method and Results: A 33-year-old patient at 18 weeks of gestation underwent removal of a 1,570-gram symptomatic fundic myoma. Histologically the patient had a leiomyomatous neoplasm of uncertain malignant potential. The pregnancy was continued under sequential observation with magnetic resonance imaging and ultrasound. At 36 weeks of gestation a healthy girl with an upper extremity limb defect was born via cesarean section. Follow-up of the mother and the child was uneventful. Conclusions: Certain known risk factors in pregnant women with myomas can predispose to complications during pregnancy. Women with such risk factors or women who have failed medical therapy should be offered the option of undergoing myomectomy as a pregnancy-preserving procedure. Copyright (C) 2002 S. Karger AG, Basel

Evidence That Hydra I is a Tidally Disrupting Milky Way Dwarf Galaxy

The Eastern Banded Structure (EBS) and Hydra I halo overdensities are very nearby (d ~ 10 kpc) objects discovered in Sloan Digital Sky Survey (SDSS) data. Previous studies of the region have shown that EBS and Hydra I are spatially coincident, cold structures at the same distance, suggesting that Hydra I may be the EBS's progenitor. We combine new wide-field Dark Energy Camera (DECam) imaging and MMT/Hectochelle spectroscopic observations of Hydra I with SDSS archival spectroscopic observations to quantify Hydra I's present-day chemodynamical properties, and to infer whether it originated as a star cluster or dwarf galaxy. While previous work using shallow SDSS imaging assumed a standard old, metal-poor stellar population, our deeper DECam imaging reveals that Hydra I has a thin, well-defined main sequence turnoff of intermediate age (~5–6 Gyr) and metallicity ([Fe/H] = −0.9 dex). We measure statistically significant spreads in both the iron and alpha-element abundances of σ_[(Fe)/H}= 0.13 ± 0.02 dex and σ_[ɑ/Fe] = 0.09 ± 0.03 dex, respectively, and place upper limits on both the rotation and its proper motion. Hydra I's intermediate age and [Fe/H]—as well as its low [α/Fe], apparent [Fe/H] spread, and present-day low luminosity—suggest that its progenitor was a dwarf galaxy, which has subsequently lost more than 99.99% of its stellar mass

Combining Stochastic Constraint Optimization and Probabilistic Programming

Algorithms and the Foundations of Software technolog

Characterising Tidal Features Around Galaxies in Cosmological Simulations

Tidal features provide signatures of recent mergers and offer a unique insight into the assembly history of galaxies. The Vera C. Rubin Observatory’s Legacy Survey of Space and Time (LSST) will enable an unprecedentedly large survey of tidal features around millions of galaxies. To decipher the contributions of mergers to galaxy evolution it will be necessary to compare the observed tidal features with theoretical predictions. Therefore, we use cosmological hydrodynamical simulations NewHorizon, eagle, IllustrisTNG, and Magneticum to produce LSST-like mock images of z ∼ 0 galaxies (z ∼ 0.2 for NewHorizon) with $M_{\scriptstyle \star ,\text{ 30 pkpc}}\ge 10^{9.5}$ M$_{\scriptstyle \odot }$. We perform a visual classification to identify tidal features and classify their morphology. We find broadly good agreement between the simulations regarding their overall tidal feature fractions: $f_{\small {\rm NEWHORIZON}}=0.40\pm 0.06$, $f_{\small {\rm EAGLE}}=0.37\pm 0.01$, $f_{\small {\rm TNG}}=0.32\pm 0.01$ and $f_{\small {\rm MAGNETICUM}}=0.32\pm 0.01$, and their specific tidal feature fractions. Furthermore, we find excellent agreement regarding the trends of tidal feature fraction with stellar and halo mass. All simulations agree in predicting that the majority of central galaxies of groups and clusters exhibit at least one tidal feature, while the satellite members rarely show such features. This agreement suggests that gravity is the primary driver of the occurrence of visually-identifiable tidal features in cosmological simulations, rather than subgrid physics or hydrodynamics. All predictions can be verified directly with LSST observations

Generating Random Logic Programs Using Constraint Programming

Testing algorithms across a wide range of problem instances is crucial to ensure the validity of any claim about one algorithm's superiority over another. However, when it comes to inference algorithms for probabilistic logic programs, experimental evaluations are limited to only a few programs. Existing methods to generate random logic programs are limited to propositional programs and often impose stringent syntactic restrictions. We present a novel approach to generating random logic programs and random probabilistic logic programs using constraint programming, introducing a new constraint to control the independence structure of the underlying probability distribution. We also provide a combinatorial argument for the correctness of the model, show how the model scales with parameter values, and use the model to compare probabilistic inference algorithms across a range of synthetic problems. Our model allows inference algorithm developers to evaluate and compare the algorithms across a wide range of instances, providing a detailed picture of their (comparative) strengths and weaknesses.Comment: This is an extended version of the paper published in CP 202

An extended star formation history in an ultra-compact dwarf

There has been significant controversy over the mechanisms responsible for forming compact stellar systems like ultra-compact dwarfs (UCDs), with suggestions that UCDs are simply the high-mass extension of the globular cluster population, or alternatively, the liberated nuclei of galaxies tidally stripped by larger companions. Definitive examples of UCDs formed by either route have been difficult to find, with only a handful of persuasive examples of stripped-nucleus-type UCDs being known. In this paper, we present very deep Gemini/GMOS spectroscopic observations of the suspected stripped-nucleus UCD NGC 4546-UCD1 taken in good seeing conditions (<0.7 arcsec). With these data we examine the spatially resolved kinematics and star formation history of this unusual object. We find no evidence of a rise in the central velocity dispersion of the UCD, suggesting that this UCD lacks a massive central black hole like those found in some other compact stellar systems, a conclusion confirmed by detailed dynamical modelling. Finally, we are able to use our extremely high signal-to-noise spectrum to detect a temporally extended star formation history for this UCD. We find that the UCD was forming stars since the earliest epochs until at least 1–2 Gyr ago. Taken together these observations confirm that NGC 4546-UCD1 is the remnant nucleus of a nucleated dwarf galaxy that was tidally destroyed by NGC 4546 within the last 1–2 Gyr

Optic Flow Stimuli in and Near the Visual Field Centre: A Group fMRI Study of Motion Sensitive Regions

Motion stimuli in one visual hemifield activate human primary visual areas of the contralateral side, but suppress activity of the corresponding ipsilateral regions. While hemifield motion is rare in everyday life, motion in both hemifields occurs regularly whenever we move. Consequently, during motion primary visual regions should simultaneously receive excitatory and inhibitory inputs. A comparison of primary and higher visual cortex activations induced by bilateral and unilateral motion stimuli is missing up to now. Many motion studies focused on the MT+ complex in the parieto-occipito-temporal cortex. In single human subjects MT+ has been subdivided in area MT, which was activated by motion stimuli in the contralateral visual field, and area MST, which responded to motion in both the contra- and ipsilateral field. In this study we investigated the cortical activation when excitatory and inhibitory inputs interfere with each other in primary visual regions and we present for the first time group results of the MT+ subregions, allowing for comparisons with the group results of other motion processing studies. Using functional magnetic resonance imaging (fMRI), we investigated whole brain activations in a large group of healthy humans by applying optic flow stimuli in and near the visual field centre and performed a second level analysis. Primary visual areas were activated exclusively by motion in the contralateral field but to our surprise not by central flow fields. Inhibitory inputs to primary visual regions appear to cancel simultaneously occurring excitatory inputs during central flow field stimulation. Within MT+ we identified two subregions. Putative area MST (pMST) was activated by ipsi- and contralateral stimulation and located in the anterior part of MT+. The second subregion was located in the more posterior part of MT+ (putative area MT, pMT)

Is standard breast-conserving therapy (BCT) in elderly breast cancer patients justified? A prospective measurement of acute toxicity according CTC-classification

<p>Abstract</p> <p>Background</p> <p>Breast conserving therapy (BCT) is an accepted treatment for early-stage breast cancer. This study aimed to measure prospectively acute radiation-related toxicity and to create a comprehensive data base for long-term temporal analyses of 3D conformal adjuvant radiotherapy. The specific aspect of age has been neglected by traditional research. Therefore, the impact of age on acute BCT toxicity should be also specifically adressed.</p> <p>Methods</p> <p>Toxicity was measured in 109 patients at initiation (t1), during radiotherapy (t2-t7), and 6 weeks after treatment completion (t8) using a new topographic module. Organ systems were recorded in 15 scales and scored according to symptom intensity (grade 0-5) based on CTC (Common Toxicity Criteria) -classification. Radiotherapy was virtually CT-based planned and applied with 6-MeV-photons. Mean total dose was 60.1 Gy. Patients were stratified by age in 3 Groups: <50, 50-60, and >60 years.</p> <p>Results</p> <p>Registered toxicity was generally low. Mean overall-grade climbed from 0.29-0.40 (t1-t7), and dropped to 0.23 (t8). Univariate analyses revealed slightly higher toxicity in older (> 60 years) versus young patients (< 50 years) in 2 scales only: breast-symmetry (p = 0.033), and arm function (p = 0.007). However, in the scale "appetite" toxicity was higher in younger (< 50 years) versus older (> 60 years) patients (p = 0.039). Toxicity differences in all other scales were not significant. Between older (> 60 years) and midaged patients (50-60 years) no significant differences in toxicity were found. This was also true for the comparison between young (< 50 years) versus midaged patient groups (50-60 years).</p> <p>Conclusion</p> <p>The treatment concept of BCT for breast cancer is generally well tolerated. The toxicity-measurement with the new topographic module is feasible. Not modified standard treatment for BC should be performed in elderly women.</p

A super-spreading ewe infects hundreds with Q fever at a farmers' market in Germany

BACKGROUND: In May 2003 the Soest County Health Department was informed of an unusually large number of patients hospitalized with atypical pneumonia. METHODS: In exploratory interviews patients mentioned having visited a farmers' market where a sheep had lambed. Serologic testing confirmed the diagnosis of Q fever. We asked local health departments in Germany to identiy notified Q fever patients who had visited the farmers market. To investigate risk factors for infection we conducted a case control study (cases were Q fever patients, controls were randomly selected Soest citizens) and a cohort study among vendors at the market. The sheep exhibited at the market, the herd from which it originated as well as sheep from herds held in the vicinity of Soest were tested for Coxiella burnetii (C. burnetii). RESULTS: A total of 299 reported Q fever cases was linked to this outbreak. The mean incubation period was 21 days, with an interquartile range of 16–24 days. The case control study identified close proximity to and stopping for at least a few seconds at the sheep's pen as significant risk factors. Vendors within approximately 6 meters of the sheep's pen were at increased risk for disease compared to those located farther away. Wind played no significant role. The clinical attack rate of adults and children was estimated as 20% and 3%, respectively, 25% of cases were hospitalized. The ewe that had lambed as well as 25% of its herd tested positive for C. burnetii antibodies. CONCLUSION: Due to its size and point source nature this outbreak permitted assessment of fundamental, but seldom studied epidemiological parameters. As a consequence of this outbreak, it was recommended that pregnant sheep not be displayed in public during the 3(rd )trimester and to test animals in petting zoos regularly for C. burnetii