Pylos and Sphacteria

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Expression alterations define unique molecular characteristics of spinal ependymomas

Ependymomas are glial tumors that originate in either intracranial or spinal regions. Although tumors from different regions are histologically similar, they are biologically distinct. We therefore sought to identify molecular characteristics of spinal ependymomas (SEPN) in order to better understand the disease biology of these tumors. Using gene expression profiles of 256 tumor samples, we identified increased expression of 1,866 genes in SEPN when compared to intracranial ependymomas. These genes are mainly related to anterior/posterior pattern specification, response to oxidative stress, glial cell differentiation, DNA repair, and PPAR signalling, and also significantly enriched with cellular senescence genes (P = 5.5 × 10-03). In addition, a high number of significantly down-regulated genes in SEPN are localized to chromosome 22 (81 genes from chr22: 43,325,255 – 135,720,974; FDR = 1.77 × 10-23 and 22 genes from chr22: 324,739 – 32,822,302; FDR = 2.07 × 10-09) including BRD1, EP300, HDAC10, HIRA, HIC2, MKL1, and NF2. Evaluation of NF2 co-expressed genes further confirms the enrichment of chromosome 22 regions. Finally, systematic integration of chromosome 22 genes with interactome and NF2 co-expression data identifies key candidate genes. Our results reveal unique molecular characteristics of SEPN such as altered expression of cellular senescence and chromosome 22 genes

Ancient Map of Asia Minor

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The Mutual Orbit, Mass, and Density of Transneptunian Binary Gknhmdm (229762 2007 UK126)

We present high spatial resolution images of the binary transneptunian object Gkn'hmdm (229762 2007 UK126) obtained with the Hubble Space Telescope and with the Keck observatory on Mauna Kea to determine the orbit of G' hG' h, the much smaller and redder satellite. G' h orbits in a prograde sense, on a circular or near-circular orbit with a period of 11.3 days and a semimajor axis of 6000 km. Tidal evolution is expected to be slow, so it is likely that the system formed already in a low-eccentricity configuration, and possibly also with the orbit plane of the satellite in or close to the plane of Gkn'hmdm's equator. From the orbital parameters we can compute the system mass to be 1.4 10(exp 20) kg. Combined with estimates of the size of Gkn'hmdm from thermal observations and stellar occultations, we can estimate the bulk density as about 1 g cm(exp 3). This low density is indicative of an ice-rich composition, unless there is substantial internal porosity. We consider the hypothesis that the composition is not unusually ice-rich compared with larger TNOs and comet nuclei, and instead the porosity is high, suggesting that mid-sized objects in the 400 to 1000 km diameter range mark the transition between small, porous objects and larger objects that have collapsed their internal void space as a result of their much higher internal pressures and temperatures

The ISO LWS high resolution spectral survey towards Sagittarius B2

A full spectral survey was carried out towards the Giant Molecular Cloud complex, Sagittarius B2 (Sgr B2), using the ISO Long Wavelength Spectrometer Fabry-Perot mode. This provided complete wavelength coverage in the range 47-196 um (6.38-1.53 THz) with a spectral resolution of 30-40 km/s. This is an unique dataset covering wavelengths inaccessible from the ground. It is an extremely important region of the spectrum as it contains both the peak of the thermal emission from dust, and crucial spectral lines of key atomic (OI, CII, OIII, NII and NIII) and molecular species (NH3, NH2, NH, H2O, OH, H3O+, CH, CH2, C3, HF and H2D+). In total, 95 spectral lines have been identified and 11 features with absorption depth greater than 3 sigma remain unassigned. Most of the molecular lines are seen in absorption against the strong continuum, whereas the atomic and ionic lines appear in emission (except for absorption in the OI 63 um and CII 158 um lines). Sgr B2 is located close to the Galactic Centre and so many of the features also show a broad absorption profile due to material located along the line of sight. A full description of the survey dataset is given with an overview of each detected species and final line lists for both assigned and unassigned features.Comment: Accepted for publication in MNRA

Combinatorial Games with a Pass: A dynamical systems approach

By treating combinatorial games as dynamical systems, we are able to address a longstanding open question in combinatorial game theory, namely, how the introduction of a "pass" move into a game affects its behavior. We consider two well known combinatorial games, 3-pile Nim and 3-row Chomp. In the case of Nim, we observe that the introduction of the pass dramatically alters the game's underlying structure, rendering it considerably more complex, while for Chomp, the pass move is found to have relatively minimal impact. We show how these results can be understood by recasting these games as dynamical systems describable by dynamical recursion relations. From these recursion relations we are able to identify underlying structural connections between these "games with passes" and a recently introduced class of "generic (perturbed) games." This connection, together with a (non-rigorous) numerical stability analysis, allows one to understand and predict the effect of a pass on a game.Comment: 39 pages, 13 figures, published versio