1,771 research outputs found
Measurement of the gluon polarisation at COMPASS
COMPASS experiment measurements of the gluon polarisation in nucleon,
DeltaG/G are reviewed. Two different approaches based on tagging the Photon
Gluon Fusion process are described. They rely on the open charm meson or
high-p_T hadron pairs detection.Comment: 4 pages, To appear in the proceedings of 42st Rencontres de Moriond
on QCD and Hadronic interactions, La Thuile, Aosta Valley, Italy, 17-24 Mar
200
eHealth interventions to support self-management: Perceptions and experiences of people with musculoskeletal disorders and physiotherapists:‘eHealth: It’s TIME’: A qualitative study
The Apoptosome Pathway to Caspase Activation in Primary Human Neutrophils Exhibits Dramatically Reduced Requirements for Cytochrome c
Caspase activation is a central event in numerous forms of apoptosis and results in the proteolytic degradation of multiple substrate proteins that contribute to the apoptotic phenotype. An important route to caspase activation proceeds via assembly of the “apoptosome” as a result of the cell stress–associated release of mitochondrial cytochrome c. Previous studies have shown that primary neutrophils are largely incapable of mitochondrial respiration, suggesting that these cells either lack functional mitochondria or possess a defective respiratory chain. This prompted us to examine whether neutrophils retain an intact cytochrome c/apoptotic protease-activating factor 1 (Apaf-1) pathway to caspase activation and apoptosis. We show that primary human neutrophils contain barely detectable levels of cytochrome c as well as other mitochondrial proteins. Surprisingly, neutrophil cell–free extracts readily supported Apaf-1–dependent caspase activation, suggesting that these cells may assemble cytochrome c–independent apoptosomes. However, further analysis revealed that the trace amount of cytochrome c present in neutrophils is both necessary and sufficient for Apaf-1–dependent caspase activation in these cells. Thus, neutrophils have a lowered threshold requirement for cytochrome c in the Apaf-1–dependent cell death pathway. These observations suggest that neutrophils retain cytochrome c for the purpose of assembling functional apoptosomes rather than for oxidative phosphorylation
Musculoskeletal Pain:Current and Future Directions of Physical Therapy Practice
Musculoskeletal (MSK) pain is 1 of the most common problems managed by clinicians in MSK care. This article reviews current frameworks for the assessment and management of MSK pain within evidence-based physical therapy practice. Key considerations related to the biopsychosocial model of pain, evidence-based practice, assessment, treatment, physical activity/movement behavior, risk stratification, communication as well as patient education and self-management skills within physical therapy and physical and rehabilitation medicine are addressed. The future direction of MSK pain management is also discussed, including strategies to promote evidence-based practice, behavior change, social prescribing, and the use of technologies.status: Published onlin
Proof of concept of prehabilitation: a combination of education and behavioural change, to promote physical activity in people with fibromyalgia
Design and development of an eHealth intervention to support self-management in people with musculoskeletal disorders - ‘eHealth: It’s TIME’: a study protocol [version 2; peer review: 2 approved]
Background: Musculoskeletal disorders (MSDs) are a leading cause of global morbidity, with the burden expected to increase in the near future. Self-management, with the support of healthcare professionals, is recommended for many MSDs. However, frequent clinical contact is not feasible. Previous research has highlighted the need for a co-designed eHealth-mediated self-management follow-up support intervention which integrates remote monitoring and behavioural change. Thus, the current study aims to develop and design a user-centred, eHealth-mediated self-management support prototype for people with MSDs. Methods: A three-step, iterative system development cycle will be utilised to develop and design the “eHealth: It’s TIME prototype”. The three-step process will include creating website features and content using two sequential focus groups with people with MSDs (n = 6 – 8); heuristic testing using the 10 heuristic principles of Nielsen (n = 5); and usability testing through in-person 60-minute interviews with people with MSDs (n = 3 – 5) and musculoskeletal physiotherapists (n = 3 – 5). Conclusion: The eHealth: It’s TIME prototype will be a systematically developed, follow-up self-management support intervention guided by behavioural change theory and the preferences of end users
Measurement of the Longitudinal Spin Transfer to Lambda and Anti-Lambda Hyperons in Polarised Muon DIS
The longitudinal polarisation transfer from muons to lambda and anti-lambda
hyperons, D_LL, has been studied in deep inelastic scattering off an
unpolarised isoscalar target at the COMPASS experiment at CERN. The spin
transfers to lambda and anti-lambda produced in the current fragmentation
region exhibit different behaviours as a function of x and xF . The measured x
and xF dependences of D^lambda_LL are compatible with zero, while
D^anti-lambda_LL tends to increase with xF, reaching values of 0.4 - 0.5. The
resulting average values are D^lambda_LL = -0.012 +- 0.047 +- 0.024 and
D^anti-lambda_LL = 0.249 +- 0.056 +- 0.049. These results are discussed in the
frame of recent model calculations.Comment: 13 pages, 7 figure
Azimuthal asymmetries of charged hadrons produced by high-energy muons scattered off longitudinally polarised deuterons
Azimuthal asymmetries in semi-inclusive production of positive (h^+) and
negative hadrons (h^-) have been measured by scattering 160 GeV muons off
longitudinally polarised deuterons at CERN. The asymmetries were decomposed in
several terms according to their expected modulation in the azimuthal angle phi
of the outgoing hadron. Each term receives contributions from one or several
spin and transverse-momentum-dependent parton distribution and fragmentation
functions. The amplitudes of all phi-modulation terms of the hadron asymmetries
integrated over the kinematic variables are found to be consistent with zero
within statistical errors, while the constant terms are nonzero and equal for
h^+ and h^- within the statistical errors. The dependencies of the
phi-modulated terms versus the Bjorken momentum fraction x, the hadron
fractional momentum z, and the hadron transverse momentum p_h^T were studied.
The x dependence of the constant terms for both positive and negative hadrons
is in agreement with the longitudinal double-spin hadron asymmetries, measured
in semi-inclusive deep-inelastic scattering. The x dependence of the sin
phi-modulation term is less pronounced than that in the corresponding HERMES
data. All other dependencies of the phi-modulation amplitudes are consistent
with zero within the statistical errors.Comment: 12 pages, 11 Figures; revision 1 signs in Eq 5 corrected, polishe
Observation of a J^PC = 1-+ exotic resonance in diffractive dissociation of 190 GeV/c pi- into pi- pi- pi+
The COMPASS experiment at the CERN SPS has studied the diffractive
dissociation of negative pions into the pi- pi- pi+ final state using a 190
GeV/c pion beam hitting a lead target. A partial wave analysis has been
performed on a sample of 420000 events taken at values of the squared
4-momentum transfer t' between 0.1 and 1 GeV^2/c^2. The well-known resonances
a1(1260), a2(1320), and pi2(1670) are clearly observed. In addition, the data
show a significant natural parity exchange production of a resonance with
spin-exotic quantum numbers J^PC = 1-+ at 1.66 GeV/c^2 decaying to rho pi. The
resonant nature of this wave is evident from the mass-dependent phase
differences to the J^PC = 2-+ and 1++ waves. From a mass-dependent fit a
resonance mass of 1660 +- 10+0-64 MeV/c^2 and a width of 269+-21+42-64 MeV/c^2
is deduced.Comment: 7 page, 3 figures; version 2 gives some more details, data unchanged;
version 3 updated authors, text shortened, data unchange
The Polarised Valence Quark Distribution from semi-inclusive DIS
The semi-inclusive difference asymmetry A^{h^{+}-h^{-}} for hadrons of
opposite charge has been measured by the COMPASS experiment at CERN. The data
were collected in the years 2002-2004 using a 160 GeV polarised muon beam
scattered off a large polarised ^6LiD target and cover the range 0.006 < x <
0.7 and 1 < Q^2 < 100 (GeV/c)^2. In leading order QCD (LO) the asymmetry
A_d^{h^{+}-h^{-}} measures the valence quark polarisation and provides an
evaluation of the first moment of Delta u_v + Delta d_v which is found to be
equal to 0.40 +- 0.07 (stat.) +- 0.05 (syst.) over the measured range of x at
Q^2 = 10 (GeV/c)^2. When combined with the first moment of g_1^d previously
measured on the same data, this result favours a non-symmetric polarisation of
light quarks Delta u-bar = - Delta d-bar at a confidence level of two standard
deviations, in contrast to the often assumed symmetric scenario Delta u-bar =
Delta d-bar = Delta s-bar = Delta s.Comment: 7 pages, 3 figures, COMPASS, revised: details added, author list
update
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