Sistem Pakar Program Diet Diabetes Mellitus Tipe 2 Berdasarkan Bmi dan Bmr Menggunakan Metode Forward Chaining dan Constraint Satisfaction Problems (Studi Kasus: Puskesmas Manduro Ngoro)

Diabetes Mellitus(DM) is one of the degenerative disease, which is one of the diseases in the top ten diseases in Indonesia. Based on the pattern of population growth, estimated in 2030 there will be194 million people with age over 20 years which have diabetes. DM will have an impact on the quality of human resources and increasing of health care cost. Both public and government shouldparticipate to evercome diabetes, especially for prevention. The number of cases of diabetes inHEALTH MANDURO are not proportional to the number of nutritional experts that are limited. Condition that occurs today is reason to create a tool that can replace the role of a nutritionist as theexpert system of diet program for people which have diabetes mellitus. Expert system is web based thediet expert system for patient which have diabetes mellitus using Constraint Satisfaction ProblemsAnd Forward Chaining method. We make the expert system program based on BMI and BMR diet can help the user or the patient to consult a diet for diabetics by providing information based on the amount of daily calories BMR (basal metabolic rate) there for services for people with diabetes inHEALTH MANDURO can be maximum. Expert systems provides information for right diet, diet schedule information for patients and convenience to the user or patient for consultation

Pengaruh Metode Penilaian Persediaan Terhadap Penentuan Harga Pokok Penjualan (Study Kasus Pada PT. Dirgantara Pancapersada Di Bandar Lampung)

This study aims to determine whether the company is able to generate a reasonable cost of goods sold in its trading inventory count and also to determine whether the inventory valuation method used by the company in accordance with the conditions of the company. Problems faced by PT. Aerospace Pancapersada is whether there is an influence on the determination of inventory valuation method of sales at PT. Aerospace Pancapersada. The hypothesis is the application of the inventory valuation method used to determine the most reasonable cost of sales at PT. Aerospace Pancapersada is FIFO.The research method used was the literature research and field research. The analytical method used is the method of qualitative and quantitative methods. Qualitative method is a method used to compare the inventory valuation method used by companies with other inventory valuation method. While quantitative methods is the method of analysis to perform calculations using numbers

Crystallographic and Magnetic Properties of the Spinel-type Ferrites ZnxCo1-xFe2O4 (0.0 <= x <= 0.75)

Ultrahigh frequencies (UHF) have applications in signal and power electronics to minimize product sizes, increase production quantity and lower manufacturing cost. In the UHF range of 300 MHz to 3 GHz, ferrimagnetic iron oxides (ferrites) are especially useful because they combine the properties of a magnetic material with that of an electrical insulator. Ferrites have much higher electrical resistivity than metallic ferromagnetic materials, resulting in minimization of the eddy current losses, and total penetration of the electromagnetic (EM) field. Hence ferrites are frequently applied as circuit elements, magnetic storage media like read/write heads, phase shifters and Faraday rotators. The electromagnetic properties of ferrites are affected by operating conditions such as field strength, temperature and frequency. The spinel system ZnxCo1-xFe2O4 (x= 0.0, 0.25, 0.50 and 0.75) has been prepared by the standard solid state sintering method. X-ray and neutron powder diffraction measurements were performed at room temperature. Neutron diffraction data analysis confirms the cubic symmetry corresponding to the space group Fd3m. The distribution of three cations Zn2+, Co2+ and Fe3+ over the spinel lattice and other crystallographic parameters like lattice constant, oxygen position parameter, overall temperature factor and occupancies of different ions in different lattice sites for the samples have been determined from the analysis of neutron diffraction data. The lattice constant increases with increasing Zn content in the system. The magnetic structure was found to be ferrimagnetic for the samples with x <= 0.50. Magnetization measurements show that with the increase of Zn content in the system the value of saturation magnetization first increases and then decreases. The variation of the magnetic moment with Zn substitution has been discussed in terms of the distribution of magnetic and non-magnetic ions over the A and B sub-lattices and their exchange coupling

Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains

This work was supported by grants from Cancer Research UK (C434/A13067), the Wellcome Trust (098391/Z/12/Z) and Biotechnology and Biological Sciences Research Council (BB/J016004/1).The RING E3 ligase catalysed formation of lysine 63 linked ubiquitin chains by the Ube2V2–Ubc13 E2 complex is required for many important biological processes. Here we report the structure of the RING domain dimer of rat RNF4 in complex with a human Ubc13~Ub conjugate and Ube2V2. The structure has captured Ube2V2 bound to the acceptor (priming) ubiquitin with Lys63 in a position that could lead to attack on the linkage between the donor (second) ubiquitin and Ubc13 that is held in the active “folded back” conformation by the RING domain of RNF4. The interfaces identified in the structure were verified by in vitro ubiquitination assays of site directed mutants. This represents the first view of the synthesis of Lys63 linked ubiquitin chains in which both substrate ubiquitin and ubiquitin-loaded E2 are juxtaposed to allow E3 ligase mediated catalysis.PostprintPeer reviewe

PENINGKATAN PENDAPATAN PETERNAK DESA BINAAN FAPET UNDANA MELALUI DIVERSIVIKASI PEMELIHARAAN TERNAK PUYUH

Abstrak Masyarakat desa binaan Fapet Undana (Desa Oelatsala) mempunyai usaha utama penggemukan sapi. Pemeliharan ternak besar ini dengan pola peternak membutuhkan waktu&nbsp; paling cepat 8 – 12 bulan untuk mendapatkan uang tunai, oleh karena itu perlu adanya usaha ternak lain atau diversivikasi usaha misalnya ternak puyuh agar dapat menopang kebutuhan keluarga peternak dalam jangka waktu yang lebih pendek. Tujuan pelatihan untuk meningkatkan pemahaman dan ketrampilan masyarakat desa binaan dalam memelihara ternak puyuh dan ayam KUB. Kegiatan ini dilakukan dengan mengikuti tahapan&nbsp; yang terdiri dari&nbsp; kegiatan pelatihan yang terdiri dari penyampaian materi dan praktek, penyerahan saprodi, pendampingan, monitoring dan evaluasi. Hasil kegiatan menunjukkan peserta latih mempunyai peluang usaha ternak puyuh&nbsp; yang menarik dapat dikerjakan karena pakannya bisa diramu dengan penambahan bahan pakan local yang tersedia disekitar mereka,&nbsp; tidak membutuhkan lahan yang luas dan mereka membutuhkan pengetahuan dan ketrampilan terkait manajemen pemeliharaan puyuh. Seluruh peserta dengan semangat berdiskusi selama penyampaian materi dan mengikuti kegiatan praktek menyusun ransum puyuh, meramu ransum puyuh, dan diikuti dengan kegiatan membuat kendang puyuh skala 25-30 ekor. Hasil monitoring dan evaluasi produksi telur diperoleh pada hari ke 46 sebanyak 38 butir (42%), adanya respon positif dari warga sekitar dengan melakukan perkunjungan dengan keinginan tahuan yang tinggi tentang beternak puyuh ini. &nbsp; &nbsp; Abstract The village community assisted by Fapet Undana (Oelatsala Village) has the main business of fattening cattle. Raising large livestock according to a farmer pattern takes at least 8 – 12 months to get cash money; therefore it is necessary to have other livestock businesses or business diversification such as quail livestock in order to support the needs of the farmer's family in a shorter period of time. The purpose of the training is to improve the knowledge and skills of the assisted village communities in raising quail and KUB chickens. This activity is carried out by following stages consisting of training activities, giving of material and practice, delivery of livestock production facilities, accompaniment, monitoring and evaluation. The results of this activity showed that the trainees have an interesting quail business opportunity that can be done because the feed can be mixed with the addition of local feed ingredients available around them, it does not require a large area of ​​land and they need knowledge and skills related to quail rearing management. All participants enthusiastically discussed during the delivery of the material and participated in practical activities of formulate quail rations, mix quail rations, and followed by make a quail cage with a capacity of 25-30 tails. The results of monitoring and evaluation of egg production were obtained on day 46 as many as 38 eggs (42%), there was a positive response from local residents by visiting with a high desire to know about rising this quail

Effects of molecular structure on the physical, chemical, and electrical properties of ester‐based transformer insulating liquids

This article presents the experimental studies carried out on the environmental friendly polyol ester insulating liquids to investigate the effect of molecular structure on the physical, chemical, and electrical properties. Six different polyol esters that can be produced from the transesterification of various methyl esters with neopentylglycol/trimethylolpropane alcohols were synthesized and compared with those of refined, bleached, and deodorized palm oil (RBDPO) and mineral transformer oil. The finding suggests that the physical properties like fire point, pour point, and viscosity are very much affected by the molecular weight and molecular composition of the polyol esters. The electrical properties are also highly influenced by the molecular structure‐related characteristics, such as the polarity, dipole polarization, carbon chain length, and degree of branching. The results confirm the findings of previous studies that the polyol esters and RBDPO have more polarity and dipole polarization compared to mineral oil. The experimental evidence showed that the newly synthesized insulating liquids have favorable thermal and electrical properties, thus suggesting that the insulating liquids have the potential to replace conventional insulating liquids to provide a more sustainable power system in the future

Antioxidant, Anti-inflammatory and Cytotoxicity of Phaleria macrocarpa (Boerl.) Scheff Fruit

<p>Abstract</p> <p>Background</p> <p><it>Phaleria macrocarpa </it>(Scheff.) Boerl (Thymelaceae) originates from Papua Island, Indonesia and grows in tropical areas. The different parts of the fruit of <it>P. macrocarpa </it>were evaluated for antioxidant, anti-inflammatory, and cytotoxic activities.</p> <p>Methods</p> <p><it>Phaleria macrocarpa </it>fruit were divided into pericarp, mesocarp and seed. All parts of the fruit were reflux extracted with methanol. The antioxidant activity of the extracts were characterized in various <it>in vitro </it>model systems such as FTC, TBA, DPPH radical, reducing power and NO radical. Anti-inflammatory assays were done by using NO production by macrophage RAW 264.7 cell lines induced by LPS/IFN-γ and cytotoxic activities were determined by using several cancer cell lines and one normal cell line</p> <p>Results</p> <p>The results showed that different parts (pericarp, mesocarp, and seed) of <it>Phaleria macrocarpa </it>fruit contain various amount of total phenolic (59.2 ± 0.04, 60.5 ± 0.17, 47.7 ± 1.04 mg gallic acid equivalent/g DW) and flavonoid compounds (161.3 ± 1.58, 131.7 ± 1.66, 35.9 ± 2.47 mg rutin equivalent/g DW). Pericarp and mesocarp showed high antioxidant activities by using DPPH (71.97%, 62.41%), ferric reducing antioxidant power (92.35%, 78.78%) and NO scavenging activity (65.68%, 53.45%). Ferric thiocyanate and thiobarbituric acid tests showed appreciable antioxidant activity in the percentage hydroperoxides inhibitory activity from pericarp and mesocarp in the last day of the assay. Similarly, the pericarp and mesocarp inhibited inducible nitric oxide synthesis with values of 63.4 ± 1.4% and 69.5 ± 1.4% in macrophage RAW 264.7 cell lines induced by LPS/IFN-γ indicating their notable anti-inflammatory potential. Cytotoxic activities against HT-29, MCF-7, HeLa and Chang cell lines were observed in all parts.</p> <p>Conclusions</p> <p>These results indicated the possible application of <it>P. macrocarpa </it>fruit as a source of bioactive compounds, potent as an antioxidant, anti inflammatory and cytotoxic agents.</p

A Mechanistic View of the Role of E3 in Sumoylation

Sumoylation, the covalent attachment of SUMO (Small Ubiquitin-Like Modifier) to proteins, differs from other Ubl (Ubiquitin-like) pathways. In sumoylation, E2 ligase Ubc9 can function without E3 enzymes, albeit with lower reaction efficiency. Here, we study the mechanism through which E3 ligase RanBP2 triggers target recognition and catalysis by E2 Ubc9. Two mechanisms were proposed for sumoylation. While in both the first step involves Ubc9 conjugation to SUMO, the subsequent sequence of events differs: in the first E2-SUMO forms a complex with the target and E3, followed by SUMO transfer to the target. In the second, Ubc9-SUMO binds to the target and facilitates SUMO transfer without E3. Using dynamic correlations obtained from explicit solvent molecular dynamic simulations we illustrate the key roles played by allostery in both mechanisms. Pre-existence of conformational states explains the experimental observations that sumoylation can occur without E3, even though at a reduced rate. Furthermore, we propose a mechanism for enhancement of sumoylation by E3. Analysis of the conformational ensembles of the complex of E2 conjugated to SUMO illustrates that the E2 enzyme is already largely pre-organized for target binding and catalysis; E3 binding shifts the equilibrium and enhances these pre-existing populations. We further observe that E3 binding regulates allosterically the key residues in E2, Ubc9 Asp100/Lys101 E2, for the target recognition

Effects of metal-contaminated soils on the accumulation of heavy metals in gotu kola (Centella asiatica) and the potential health risks: a study in Peninsular Malaysia

Centella asiatica is a commonly used medicinal plant in Malaysia. As heavy metal accumulation in medicinal plants which are highly consumed by human is a serious issue, thus the assessment of heavy metals in C. asiatica is important for the safety of consumers. In this study, the heavy metal accumulation in C. asiatica and the potential health risks were investigated. Samples of C. asiatica and surface soils were collected from nine different sites around Peninsular Malaysia. The concentration of six heavy metals namely Cd, Cu, Ni, Fe, Pb and Zn were determined by air-acetylene flame atomic absorption spectrophotometer (AAS). The degree of anthropogenic influence was assessed by calculating the enrichment factor (EF) and index of geoaccumulation (Igeo). The heavy metal uptake into the plant was estimated through the calculation of translocation factor (TF), bioconcentration factor (BCF) and correlation study. Estimated daily intakes (EDI) and target hazard quotients (THQ) were used to determine the potential health risk of consuming C. asiatica. The results showed that the overall surface soil was polluted by Cd, Cu and Pb, while the uptake of Zn and Ni by the plants was high. The value of EDI and THQ showed that the potential of Pb toxicity in C. asiatica was high as well. As heavy metal accumulation was confirmed in C. asiatica, daily consumption of the plant derived from polluted sites in Malaysia was not recommended