Association rule hiding using integer linear programming

Privacy preserving data mining has become the focus of attention of government statistical agencies and database security research community who are concerned with preventing privacy disclosure during data mining. Repositories of large datasets include sensitive rules that need to be concealed from unauthorized access. Hence, association rule hiding emerged as one of the powerful techniques for hiding sensitive knowledge that exists in data before it is published. In this paper, we present a constraint-based optimization approach for hiding a set of sensitive association rules, using a well-structured integer linear program formulation. The proposed approach reduces the database sanitization problem to an instance of the integer linear programming problem. The solution of the integer linear program determines the transactions that need to be sanitized in order to conceal the sensitive rules while minimizing the impact of sanitization on the non-sensitive rules. We also present a heuristic sanitization algorithm that performs hiding by reducing the support or the confidence of the sensitive rules. The results of the experimental evaluation of the proposed approach on real-life datasets indicate the promising performance of the approach in terms of side effects on the original database

Directional translocation resistance of Zika xrRNA

xrRNAs from flaviviruses survive in host cells because of their exceptional dichotomic response to the unfolding action of different enzymes. They can be unwound, and hence copied, by replicases, and yet can resist degradation by exonucleases. How the same stretch of xrRNA can encode such diverse responses is an open question. Here, by using atomistic models and translocation simulations, we uncover an elaborate and directional mechanism for how stress propagates when the two xrRNA ends, 5 \u2032 and 3 \u2032, are driven through a pore. Pulling the 3 \u2032 end, as done by replicases, elicits a progressive unfolding; pulling the 5 \u2032 end, as done by exonucleases, triggers a counterintuitive molecular tightening. Thus, in what appears to be a remarkable instance of intra-molecular tensegrity, the very pulling of the 5 \u2032 end is what boosts resistance to translocation and consequently to degradation. The uncovered mechanistic principle might be co-opted to design molecular meta-materials

Utilization of fresh frozen plasma in a tertiary care hospital in central Kerala

Background: The demand for blood and its components always exceeds the supply in our health care setting. Hence there is a need to prioritize the usage of these components. An audit makes this possible. The present study is conducted on utilization of Fresh frozen plasma which is one of the most requested blood components.Methods: The study was conducted on the first 241 FFP transfusions during the study period of 1 year. Requisition forms for issuing FFP from various departments were reviewed and relevant data collected. Patients’ case record was also retrieved to collect data related to the transfusion episodes. The data collected were compiled, coded and expressed using descriptive statistical tools like mean, mode, percentage and ratio using Microsoft Excel 2010.Results: Most of the patients who underwent FFP transfusion were males and in the age group 60-70. Most of the requests for FFP issue came from Cardiothoracic department. Most common indication for FFP transfusion was raised PT INR. FFP units remained unutilized in CTVS, General surgery and general medicine. 20% of the received request forms were incompletely filled with the Clinical diagnosis and Indication for FFP being most frequently omitted information.Conclusions: Various departments at Government Medical College, Kottayam are efficiently utilizing FFP. But more intervention is needed in addressing issues related to the sending of requisition forms and ensuring adequate usage of FFP to prevent its wastage

Monitoring of arthropod infestations on high quality hard wheat in southern Italy

The results of a survey in 2006-2009 on high quality hard wheat, coming from 31 different storage centers located in Southern Italy, are reported. About 300 samples were analyzed by visual test, while 891 by both sieving and biological test. For the three different kinds of test the infesting species are listed and their relative incidence on the samples is reported. The most widespread species in the samples belonged to the order Coleoptera, i.e. Sitophilus granarius, Rhyzopertha dominica and Oryzaephilus spp., while Lepidoptera were less abundant. The results are discussed with the aim of providing the storage centre operators with helpful information on the correct monitoring strategies to adopt in case of arthropod infestations in high-quality hard-wheat warehouses.Keywords: Stored grain, Insects, Sampling, Coleoptera, Ital

To evaluate the effect of Dashamula Churna Pinda Sweda a touchstone procedure in the management of Vatakantaka

Vatakantaka is disease of foot and heel with Kantakavat Vedana. Vatakantaka is non fatal common condition which makes life miserable due to pain. When Vata gets vitiated due to walking long distance, excessive strain, walking on uneven surface, the vitiated Vata dosha gets accumulated in Khuddal pradesha (ankle) and causes pain as if pricked by thorn. Hence termed as Vatakantaka. Vatakantaka can be co-related to Calcaneal spur in modern parlance. Calcaneal spur is a pointed bony growth on calcaneus bone. The incidence of calcaneal spur in normal population is 15.5%. And in South Indian population it is 59% of which 60% are female. Here 10 cases of Vatatakantaka vis-a-vis Calcaneal spur were subjected to Dashamula Churna Pinda Sweda for 7 days, followed by Nirgundi Guggulu for 30 days. Patients showed significant results in subjective and objective parameters

Characteristic Study of Combined eects of MHD and Coriolis Force on Free Convection in a Rectangular Cavity with Isotropic and Anisotropic Porous Media

This investigation deals with the classic Rayleigh - Benard problem for a laminar, viscous, unsteady incompressible fluid flow heated from below is extended to three-dimensional convection in a nite geometry with isotropic and anisotropic porous media rotating with constant angular velocity and the magnetic eld is applied in the vertical direction. For the given physical set-up, governing partial differential equations are transformed to a set of non-dimensional ordinary differential equations using similarity transformation. This demands to apply Fourier series method to study the characteristic of velocity, temperature and concentration for the effect of Taylors number, Rayleigh number, Hartmanns number and Prandtl number for both anisotropic and isotropic porous media. The results of steam function and isotherms on various parameters have been discussed and found to be good agreement for the physical system

Work fluctuations of self-propelled particles in the phase separated state

We study the large deviations of the distribution P(W_\tau) of the work associated with the propulsion of individual active brownian particles in a time interval \tau, in the region of the phase diagram where macroscopic phase separation takes place. P(W_\tau) is characterised by two peaks, associated to particles in the gaseous and in the clusterised phases, and two separate non-convex branches. Accordingly, the generating function of W_\tau cumulants displays a double singularity. We discuss the origin of such non-convex branches in terms of the peculiar dynamics of the system phases, and the relation between the observation time \tau and the typical persistence times of the particles in the two phases.Comment: 7 pages, 5 figure

Autosomal Dominant Retinal Dystrophies Caused by a Founder Splice Site Mutation, c.828+3A>T, in PRPH2 and Protein Haplotypes in trans as Modifiers.

PurposeWe determined the phenotypic variation, disease progression, and potential modifiers of autosomal dominant retinal dystrophies caused by a splice site founder mutation, c.828+3A>T, in the PRPH2 gene.MethodsA total of 62 individuals (19 families) harboring the PRPH2 c.828+3A>T mutation, had phenotype analysis by fundus appearance, electrophysiology, and visual fields. The PRPH2 haplotypes in trans were sequenced for potential modifying variants and generalized estimating equations (GEE) used for statistical analysis.ResultsSeveral distinct phenotypes caused by the PRPH2 c.828+3A>T mutation were observed and fell into two clinical categories: Group I (N = 44) with mild pattern dystrophies (PD) and Group II (N = 18) with more severe cone-rod dystrophy (CRD), retinitis pigmentosa (RP), and central areolar chorioretinal dystrophy (CACD). The PRPH2 Gln304-Lys310-Asp338 protein haplotype in trans was found in Group I only (29.6% vs. 0%), whereas the Glu304-Lys310-Gly338 haplotype was predominant in Group II (94.4% vs. 70.4%). Generalized estimating equations analysis for PD versus the CRD/CACD/RP phenotypes in individuals over 43 years alone with the PRPH2 haplotypes in trans and age as predictors, adjusted for correlation within families, confirmed a significant effect of haplotype on severity (P = 0.03) with an estimated odds ratio of 7.16 (95% confidence interval [CI] = [2.8, 18.4]).ConclusionsThe PRPH2 c.828+3A>T mutation results in multiple distinct phenotypes likely modified by protein haplotypes in trans; the odds of having the CACD/RP-like phenotype (versus the PD phenotype) are 7.16 times greater with a Glu304-Lys310-Gly338 haplotype in trans. Further functional studies of the modifying haplotypes in trans and PRPH2 splice variants may offer therapeutic targets