Symptoms of anal incontinence and quality of life : A psychometric study of the Norwegian version of the ICIQ-B amongst hospital outpatients

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Exploring diffrent design spaces - VR as a tool during building design

During the design process of a building different medias are often used to depict the design. Traditional media, especially 2D requires high spatial skill and cognitive demand on the designers. For inexperienced designers, this process can be demanding, be difficult and can cause potential biased designperceptions that are significantly different from the reality. However, studies have also shown that different media and representation facilitates different cognitive reasoning processes about the design. Immersive Virtual Reality (VR) is assumed to give another level of understanding and perception of design space from an egocentric perception than 2D plan drawings or bird-eye views, which have been argued to provide opportunities for better pattern and object recognition that is suitable when studying spatial organization in an allocentric reasoning process. This paper investigates, the different design medias and spatial space explorations further, by studying how students used the different representations and medias (e.g. sketches, 3d-models and VR) during their design process. By combining and using both of these two design space representations, (e.g. egocentric and allocentric) in the design process, it gives a possibility to achieve a more developed design outcome. The methods used in this study were observations and un-structured interviews during the design process and a follow up questionnaire at the end of the design project. The result show, by combining and using both VR and traditional design sketching tools that it is possible to support the two design space representations together and give the designer the possibilities to explore, understand, discuss and work with the design in a more elaborate way from both an egocentric and allocentric perspective. The paper also presents in what way VR can contribute to the Evidence Based Design (EBD) criteria and how the students used different design spaces representations for design and spatial reasoning about the healthcare design of the psychiatric facility they were designing

Principal series of finite subgroups of SU(3)

We attempt to give a complete description of the "exceptional" finite subgroups Sigma(36x3), Sigma(72x3) and Sigma(216x3) of SU(3), with the aim to make them amenable to model building for fermion masses and mixing. The information on these groups which we derive contains conjugacy classes, proper normal subgroups, irreducible representations, character tables and tensor products of their three-dimensional irreducible representations. We show that, for these three exceptional groups, usage of their principal series, i.e. ascending chains of normal subgroups, greatly facilitates the computations and illuminates the relationship between the groups. As a preparation and testing ground for the usage of principal series, we study first the dihedral-like groups Delta(27) and Delta(54) because both are members of the principal series of the three groups discussed in the paper.Comment: 43 pages, no figures; typos corrected, clarifications and references added, version matches publication in J. Phys.

Embelin binds to human neuroserpin and impairs its polymerisation

Neuroserpin (NS) is a serpin inhibitor of tissue plasminogen activator (tPA) in the brain. The polymerisation of NS pathologic mutants is responsible for a genetic dementia known as familial encephalopathy with neuroserpin inclusion bodies (FENIB). So far, a pharmacological treatment of FENIB, i.e. an inhibitor of NS polymerisation, remains an unmet challenge. Here, we present a biophysical characterisation of the effects caused by embelin (EMB a small natural compound) on NS conformers and NS polymerisation. EMB destabilises all known NS conformers, specifically binding to NS molecules with a 1:1 NS:EMB molar ratio without unfolding the NS fold. In particular, NS polymers disaggregate in the presence of EMB, and their formation is prevented. The NS/EMB complex does not inhibit tPA proteolytic activity. Both effects are pharmacologically relevant: firstly by inhibiting the NS polymerisation associated to FENIB, and secondly by potentially antagonizing metastatic processes facilitated by NS activity in the brain

Normal neonatal TREC and KREC levels in early onset juvenile idiopathic arthritis

Objective: Dysregulated central tolerance predisposes to autoimmune diseases. Reduced thymic output as well as compromised central B cell tolerance checkpoints have been proposed in the pathogenesis of juvenile idiopathic arthritis (JIA). The aim of this study was to investigate neonatal levels of T-cell receptor excision circles (TRECs) and kappa-deleting element excision circles (KRECs), as markers of T- and B-cell output at birth, in patients with early onset JIA. Methods: TRECs and KRECs were quantitated by multiplex qPCR from dried blood spots (DBS), collected 2–5 days after birth, in 156 children with early onset JIA and in 312 matched controls. Results: When analysed from neonatal dried blood spots, the median TREC level was 78 (IQR 55–113) in JIA cases and 88 (IQR 57–117) copies/well in controls. The median KREC level was 51 (IQR 35–69) and 53 (IQR 35–74) copies/well, in JIA cases and controls, respectively. Stratification by sex and age at disease onset did not reveal any difference in the levels of TRECs and KRECs. Conclusion: T- and B-cell output at birth, as measured by TREC and KREC levels in neonatal dried blood spots, does not differ in children with early onset JIA compared to controls

The prognosis for individuals on disability retirement An 18-year mortality follow-up study of 6887 men and women sampled from the general population

BACKGROUND: Several studies have shown a markedly higher mortality rate among disability pensioners than among non-retired. Since most disability pensions are granted because of non-fatal diseases the reason for the increased mortality therefore remains largely unknown. The aim of this study was to evaluate potential explanatory factors. METHODS: Data from five longitudinal cohort studies in Sweden, including 6,887 men and women less than 65 years old at baseline were linked to disability pension data, hospital admission data, and mortality data from 1971 until 2001. Mortality odds ratios were analyzed with Poisson regression and Cox's proportional hazards regression models. RESULTS: 1,683 (24.4%) subjects had a disability pension at baseline or received one during follow up. 525 (7.6%) subjects died during follow up. The subjects on disability pension had a higher mortality rate than the non-retired, the hazards ratio (HR) being 2.78 (95%CI 2.08–3.71) among women and 3.43 (95%CI 2.61–4.51) among men. HR was highest among individuals granted a disability pension at young ages (HR >7), and declined parallel to age at which the disability pension was granted. The higher mortality rate among the retired subjects was not explained by disability pension cause or underlying disease or differences in age, marital status, educational level, smoking habits or drug abuse. There was no significant association between reason for disability pension and cause of death. CONCLUSION: Subjects with a disability pension had increased mortality rates as compared with non-retired subjects, only modestly affected by adjustments for psycho-socio-economic factors, underlying disease, etcetera. It is unlikely that these factors were the causes of the unfavorable outcome. Other factors must be at work

A novel immunoscintigraphy technique using metabolizable linker with angiotensin II treatment

Immunoscintigraphy is a tumour imaging technique that can have specificity, but high background radioactivity makes it difficult to obtain tumour imaging soon after the injection of radioconjugate. The aim of this study is to see whether clear tumour images can be obtained soon after injection of a radiolabelled reagent using a new linker with antibody fragments (Fab), in conditions of induced hypertension in mice. Fab fragments of a murine monoclonal antibody against human osteosarcoma were labelled with radioiodinated 3′-iodohippuryl N-ɛ-maleoyl-L-lysine (HML) and were injected intravenously to tumour-bearing mice. Angiotensin II was administered for 4 h before and for 1 h after the injection of radiolabelled Fab. Kidney uptake of 125I-labelled-HML-Fab was much lower than that of 125I-labelled-Fab radioiodinated by the chloramine-T method, and the radioactivity of tumour was increased approximately two-fold by angiotensin II treatment at 3 h after injection, indicating high tumour-to-normal tissue ratios. A clear tumour image was obtained with 131I-labelled-HML-Fab at 3 h post-injection. The use of HML as a radiolabelling reagent, combined with angiotensin II treatment, efficiently improved tumour targeting and enabled the imaging of tumours. These results suggest the feasibility of PET scan using antibody fragment labelled with 18F-fluorine substitute for radioiodine. © 1999 Cancer Research Campaig