A differential game of evasion from many pursuers

This paper considers a game problem with many pursuers described by infinite systems of differential equations of second order. On the controls of players geometric constraints are imposed. The aim of the pursuers is to capture the evader,while the aim of the evader is the opposite. The theorem on evasion is proved in this paper

PERBANDINGAN DESAIN TEBAL PERKERASAN LENTUR LAPIS TAMBAH (OVERLAY) DENGAN METODE BINA MARGA REVISI JUNI 2017 MENGGUNAKAN DATA LENDUTAN BB DAN AASHTO 1993 MENGGUNAKAN DATA LENDUTAN FWD (STUDI KASUS: RUAS JALAN NASIONAL JENDERAL SUDIRMAN – MANADO, NOMOR RUAS JALAN 5000413)

Jalan raya merupakan bagian dari sarana transportasi darat yang sangat penting dalam menunjang akses mobalitas bagi masyarakat, sehingga desain perkerasan jalan yang baik adalah suatu keharusan untuk meningkatan nilai dari fungsi jalan. Pada ruas jalan Nasional Jenderal Sudirman-Manado yang adalah jalan lama dengan tipe jalan arteri 1 arah 4 lajur diamati secara visual di beberapa segmen jalan terdapat kerusakan fungsional dan telah mengarah pada kerusakan struktural. Kondisi ruas jalan pada lokasi penelitian akibat kerusakan struktural dilakukan pemeriksaan non- destruktif dengan pengujian menggunakan alat Falling Weight Deflectometer (FWD) dan Benkelman Beam (BB) yang menghasilkan data lendutan.Tujuan penelitian ini untuk mengetahui dan membandingkan hasil tebal lapis tambah (overlay) berdasarkan metode Bina Marga Revisi Juni 2017 dengan AASHTO 1993. Data yang digunakan dalam penelitian merupakan data sekunder yang diperoleh dari BPJN Sulawesi Utara yaitu Volume Lalu Lintas (LHR), data Struktur Lapisan Tebal Perkerasan Jalan Eksisting, Data Lendutan FWD dan Data Lendutan BB. Untuk data lendutan Benkelman Beam (BB) tidak tersedia dari Balai Jalan, sehingga dilakukan perhitungan dengan model menggunakan data lendutan FWD.Perhitungan CESA (Cumulative Equivalent Single Axle) berdasarkan metode Bina Marga 2017 diperoleh nilai CESA4 = 1.226.974 dan CESA5 = 1.307.388 menurut metode AASHTO 1993 W18 = 6.159.474,28. Dari hasil perhitungan pada Metode Bina Marga 2017 diperoleh overlay untuk CESA4 sebesar 2 cm dan untuk CESA5 sebesar 10 cm, sementara itu pada metode AASHTO 1993 dengan CESA (W18) mendapatkan overlay sebesar 5 cm. Perbandingan dari hasil perhitungan desain tebal lapis tambah (overlay) dengan metode Bina Marga 2017 dan metode AASHTO 1993 ditinjau berdasarkan parameter dari masing-masing metode. Dalam penelitian ini dilakukan juga simulasi dengan variasi beban lalu lintas (CESA) terhadap tebal lapis tambah (overlay) dimana model Polynomial Orde 6 menghasilkan nilai r2 paling besar dan menjadi pemilihan model terbaik. Kata Kunci: Bina Marga Revisi Juni 2017; AASHTO 1993; VDF; CESA; Benkelman Beam; Falling Weight Deflectometer; Overlay

Раневые покрытия и синдром диабетической стопы

Materials and Methods. There was proposed an original algorithm for a comprehensive assessment of the wound process and methods of using modern wound coatings. It was based on the results of examination and treatment of 102 patients with purulent-necrotic complications of diabetic foot syndrome (DFS), who were treated at the clinic of General surgery of the Military medical Academy from 2015 to 2017.Results. The data obtained after planimetric, bacteriological and cytological research fully confirm the effectiveness of modern wound coatings.Conclusion. The suggested algorithm provides an objective assessment of wound process, also demonstrates its dynamics, allows to compare different methods of local treatment, as well as to adjust the treatment regimen of patients with purulent-necrotic complications of DFS.Материалы и методы. На основе результатов обследования и лечения 102 пациентов с гнойно-некротическими осложнениями синдрома диабетической стопы (СДС), находившихся на лечении в клинике общей хирургии Военно-медицинской академии с 2015 по 2017 год, с целью улучшения результатов лечения был предложен оригинальный алгоритм комплексной оценки течения раневого процесса и методики применения современных раневых покрытий.Результаты. Полученные в результате планиметрических, бактериологических и цитологических методов исследования данные полностью подтверждают эффективность современных раневых покрытий.Заключение. Предложенный алгоритм обеспечивает объективизацию оценки раневого процесса, демонстрирует его динамику, позволяет сравнить различные методы местного лечения, а также корректировать схему ведения пациентов с гнойно-некротическими осложнениями СДС

Relational practices and reflexivity: Exploring the responses of women entrepreneurs to changing household dynamics

This qualitative study explores how and why women, positioned as mothers, wives, or carers, navigate changing household dynamics, related to care and reproductive resources, and become entrepreneurial. Drawing on relational reflexivity, we show how women’s embodied, intimate relations with important others in the household form the focal point for entrepreneurial activities and offer evidence of their entrepreneurial agency. Our analysis reveals the emergence of three relational practices that result in a new venture as the entrepreneurial response of women. We critically evaluate normative analyses on gender, entrepreneurship, and household

Perceived Devaluation and STI Testing Uptake among a Cohort of Street-involved Youth in a Canadian Setting

Perceived devaluation has been shown to have adverse effects on the mental and physical health outcomes of people who use drugs. However, the impact of perceived devaluation on sexually transmitted infections (STI) testing uptake among street-involved youth, who face multiple and intersecting stigmas due to their association with drug use and risky sexual practices, has not been fully characterized. Data were obtained between December 2013 and November 2014 from a cohort of street-involved youth who use illicit drugs aged 14–26 in Vancouver, British Columbia. Multivariable generalized estimating equations were constructed to assess the independent relationship between perceived devaluation and STI testing uptake. Among 300 street-involved youth, 87.0% reported a high perceived devaluation score at baseline. In the multivariable analysis, high perceived devaluation was negatively associated with STI testing uptake after adjustment for potential confounders (Adjusted Odds Ratio = 0.38, 95% Confidence Interval 0.15–0.98). Perceived devaluation was high among street-involved youth in our sample and appears to have adverse effects on STI testing uptake. HIV prevention and care programs should be examined and improved to better meet the special needs of street-involved youth in non-stigmatizing ways

Open Problems on Central Simple Algebras

We provide a survey of past research and a list of open problems regarding central simple algebras and the Brauer group over a field, intended both for experts and for beginners.Comment: v2 has some small revisions to the text. Some items are re-numbered, compared to v

Social work and gender::An argument for practical accounts

This article contributes to the debate on gender and social work by examining dominant approaches within the field. Anti-discriminatory, woman-centered and intersectional accounts are critiqued for reliance upon both reification and isolation of gender. Via examination of poststructural, queer and trans theories within social work, the author then presents accounts based upon structural/materialist, ethnomethodological and discursive theories, in order to open up debates about conceptualization of gender. These are used to suggest that social work should adopt a focus on gender as a practical accomplishment that occurs within various settings or contexts

Exome sequencing in suspected monogenic dyslipidemias

Exome sequencing is a promising tool for gene mapping in Mendelian disorders. We used this technique in an attempt to identify novel genes underlying monogenic dyslipidemias

Exome Sequencing in Suspected Monogenic Dyslipidemias

Abstract BACKGROUND: -Exome sequencing is a promising tool for gene mapping in Mendelian disorders. We utilized this technique in an attempt to identify novel genes underlying monogenic dyslipidemias. METHODS AND RESULTS: -We performed exome sequencing on 213 selected family members from 41 kindreds with suspected Mendelian inheritance of extreme levels of low-density lipoprotein (LDL) cholesterol (after candidate gene sequencing excluded known genetic causes for high LDL cholesterol families) or high-density lipoprotein (HDL) cholesterol. We used standard analytic approaches to identify candidate variants and also assigned a polygenic score to each individual in order to account for their burden of common genetic variants known to influence lipid levels. In nine families, we identified likely pathogenic variants in known lipid genes (ABCA1, APOB, APOE, LDLR, LIPA, and PCSK9); however, we were unable to identify obvious genetic etiologies in the remaining 32 families despite follow-up analyses. We identified three factors that limited novel gene discovery: (1) imperfect sequencing coverage across the exome hid potentially causal variants; (2) large numbers of shared rare alleles within families obfuscated causal variant identification; and (3) individuals from 15% of families carried a significant burden of common lipid-related alleles, suggesting complex inheritance can masquerade as monogenic disease. CONCLUSIONS: -We identified the genetic basis of disease in nine of 41 families; however, none of these represented novel gene discoveries. Our results highlight the promise and limitations of exome sequencing as a discovery technique in suspected monogenic dyslipidemias. Considering the confounders identified may inform the design of future exome sequencing studies