The Relationship of Hard X-ray and Optical Line Emission in Low Redshift Active Galactic Nuclei

In this paper we assess the relationship of the population of Active Galactic Nuclei (AGN) selected by hard X-rays to the traditional population of AGN with strong optical emission lines. First, we study the emission-line properties of a new hard X-ray selected sample of 47 local AGN (classified optically as both Type 1 and Type 2 AGN). We find that the hard X- ray (3-20 keV) and [OIII]$\lambda$5007 optical emission-line luminosities are well-correlated over a range of about four orders-of-magnitude in luminosity (mean luminosity ratio 2.15 dex with a standard deviation of $\sigma$ = 0.51 dex). Second, we study the hard X-ray properties of a sample of 55 local AGN selected from the literature on the basis of the flux in the [OIII] line. The correlation between the hard X-ray (2-10 keV) and [OIII] luminosity for the Type 1 AGN is consistent with what is seen in the hard X-ray selected sample. However, the Type 2 AGN have a much larger range in the luminosity ratio, and many are very weak in hard X-rays (as expected for heavily absorbed AGN). We then compare the hard X-ray (3-20 keV) and [OIII] luminosity functions of AGN in the local universe. These have similar faint-end slopes with a luminosity ratio of 1.60 dex (0.55 dex smaller than the mean value for individual hard X-ray selected AGN). We conclude that at low redshift, selection by narrow optical emission- lines will recover most AGN selected by hard X-rays (with the exception of BL Lac objects). However, selection by hard X-rays misses a significant fraction of the local AGN population with strong emission lines

Operator algebras from the discrete Heisenberg semigroup

We study reflexivity and structure properties of operator algebras generated by representations of the discrete Heisenberg semi-group. We show that the left regular representation of this semi-group gives rise to a semi-simple reflexive algebra. We exhibit an example of a representation which gives rise to a non-reflexive algebra. En route, we establish reflexivity results for subspaces of H^{\infty}(\bb{T})\otimes\cl B(\cl H)

Chronic toxic encephalopathy in a painter exposed to mixed solvents.

This paper describes symptoms and findings in a 57-year-old painter who had been exposed to various organic solvents for over 30 years. He began to work as a painter at 16 years of age, frequently working in poorly ventilated areas; he used solvents to remove paint from the skin of his arms and hands at the end of each work shift. The patient and his family noticed impaired short-term memory function and changes in affect in his early forties, which progressed until after he stopped working and was thus no longer exposed to paints and solvents. After the patient's exposures had ended, serial neuropsychological testing revealed persistent cognitive deficits without evidence of further progression, and improvement in some domains. Magnetic resonance imaging revealed global and symmetrical volume loss, involving more white than gray matter. The findings in this patient are consistent with chronic toxic encephalopathy and are differentiated from other dementing processes such as Alzheimer's disease, multi-infarct (vascular) dementia, and alcoholic dementia. Previous descriptions in the literature of persistent neurobehavioral effects associated with chronic exposure to organic solvents corroborate the findings in this case

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals.

Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption. Viral rebound may be induced from several cellular subsets; however, the majority of proviral DNA has been found in antigen experienced resting CD4+ T cells. To achieve a cure for HIV-1, eradication strategies depend upon both understanding mechanisms that drive HIV-1 persistence as well as sensitive assays to measure the frequency of infected cells after therapeutic interventions. Assays such as the quantitative viral outgrowth assay (QVOA) measure HIV-1 persistence during ART by ex vivo activation of resting CD4+ T cells to induce latency reversal; however, recent studies have shown that only a fraction of replication-competent viruses are inducible by primary mitogen stimulation. Previous studies have shown a correlation between the acquisition of effector memory phenotype and HIV-1 latency reversal in quiescent CD4+ T cell subsets that harbor the reservoir. Here, we apply our mechanistic understanding that differentiation into effector memory CD4+ T cells more effectively promotes HIV-1 latency reversal to significantly improve proviral measurements in the QVOA, termed differentiation QVOA (dQVOA), which reveals a significantly higher frequency of the inducible HIV-1 replication-competent reservoir in resting CD4+ T cells

Relativistic Iron K Emission and absorption in the Seyfert 1.9 galaxy MCG-5-23-16

We present the results of the simultaneous deep XMM and Chandra observations of the bright Seyfert 1.9 galaxy MCG-5-23-16, which is thought to have one of the best known examples of a relativistically broadened iron K-alpha line. The time averaged spectral analysis shows that the iron K-shell complex is best modeled with an unresolved narrow emission component (FWHM < 5000 km/s, EW ~ 60 eV) plus a broad component. This latter component has FWHM ~ 44000 km/s and EW ~ 50 eV. Its profile is well described by an emission line originating from an accretion disk viewed with an inclination angle ~ 40^\circ and with the emission arising from within a few tens of gravitational radii of the central black hole. The time-resolved spectral analysis of the XMM EPIC-pn spectrum shows that both the narrow and broad components of the Fe K emission line appear to be constant in time within the errors. We detected a narrow sporadic absorption line at 7.7 keV which appears to be variable on a time-scale of 20 ksec. If associated with Fe XXVI Ly-alpha this absorption is indicative of a possibly variable, high ionization, high velocity outflow. The variability of this absorption feature appears to rule out a local (z=0) origin. The analysis of the XMM RGS spectrum reveals that the soft X-ray emission of MCG-5-23-16 is likely dominated by several emission lines superimposed on an unabsorbed scattered power-law continuum. The lack of strong Fe L shell emission together with the detection of a strong forbidden line in the O VII triplet is consistent with a scenario where the soft X-ray emission lines are produced in a plasma photoionized by the nuclear emission.Comment: 45 pages, 12 figures, 4 tables, accepted for publication in Ap

Enhanced Potency of Bivalent Small Molecule gp41 Inhibitors

Low molecular weight peptidomimetic inhibitors with hydrophobic pocket binding properties and moderate fusion inhibitory activity against HIV-1 gp41-mediated cell fusion were elaborated by increasing the available surface area for interacting with the heptad repeat-1 (HR1) coiled coil on gp41. Two types of modifications were tested: 1) increasing the overall hydrophobicity of the molecules with an extension that could interact in the HR1 groove, and 2) forming symmetrical dimers with two peptidomimetic motifs that could potentially interact simultaneously in two hydrophobic pockets on the HR1 trimer. The latter approach was more successful, yielding 40–60 times improved potency against HIV fusion over the monomers. Biophysical characterization, including equilibrium binding studies by fluorescence and kinetic analysis by Surface Plasmon Resonance, revealed that inhibitor potency was better correlated to off-rates than to binding affinity. Binding and kinetic data could be fit to a model of bidentate interaction of dimers with the HR1 trimer as an explanation for the slow off-rate, albeit with minimal cooperativity due to the highly flexible ligand structures. The strong cooperativity observed in fusion inhibitory activity of the dimers implied accentuated potency due to the transient nature of the targeted intermediate. Optimization of monomer, dimer or higher order structures has the potential to lead to highly potent non-peptide fusion inhibitors by targeting multiple hydrophobic pockets

Detection of bridging veins rupture and subdural haematoma onset using a finite element head model

One of the most severe traumatic brain injuries, the subdural haematoma, is related to damage and rupture of the bridging veins, generating an abnormal collection of blood between the dura mater and arachnoid mater. Current numerical models of these vessels rely on very simple geometries and material laws, limiting its accuracy and bio-fidelity.publishe

Wide-band spectroscopy of the Compton thick Seyfert 2 galaxy Mrk 3 with Suzaku

We obtained a wide-band spectrum of the Compton-thick Seyfert 2 galaxy Mrk 3 with Suzaku. The observed spectrum was clearly resolved into weak, soft power-law emission, a heavily absorbed power-law component, cold reflection, and many emission lines. The heavily absorbed component, absorbed by gas with a column density of 1.1x10^24 cm^-2, has an intrinsic 2--10 keV luminosity of ~1.6x10^43 erg s^-1, and is considered to be direct emission from the Mrk 3 nucleus. The reflection component was interpreted as reflection of the direct light off cold, thick material; the reflection fraction $R$ was 1.36+/-0.20. The cold material is inferred to be located > 1 pc from the central black hole of Mrk 3 due to the low ionization parameter of iron (xi < 1 erg cm s^-1) and the narrow iron line width (s < 22 eV). A Compton shoulder to the iron line was detected, but the intensity of the shoulder component was less than that expected from spherically distributed Compton-thick material. The weak, soft power-law emission is considered to be scattered light by ionized gas. The existence of many highly-ionized lines from O, Ne, Mg, Si, S, and Fe in the observed spectrum indicates that the ionized gas has a broad ionized structure, with xi=10--1000. The scattering fraction with respect to the direct light was estimated to be 0.9+/-0.2%, which indicates that the column density of the scattering region is about 3.6x10^22 cm^-2. This high-quality spectrum obtained by Suzaku can be considered a template for studies of Seyfert 2 galaxies.Comment: 24 pages, 8 figures, accepted in PASJ for publicatio