224 research outputs found
A CF3I-based SDD Prototype for Spin-independent Dark Matter Searches
The application of Superheated Droplet Detectors (SDDs) to dark matter
searches has so far been confined to the light nuclei refrigerants C2ClF5 and
C4F10 (SIMPLE and PICASSO, respectively), with a principle sensitivity to
spin-dependent interactions. Given the competitive results of these devices, as
a result of their intrinsic insensitivity to backgrounds, we have developed a
prototype trifluoroiodomethane (CF3I)-loaded SDD with increased sensitivity to
spin-independent interactions as well. A low (0.102 kgd) exposure test
operation of two high concentration, 1 liter devices is described, and the
results compared with leading experiments in both spin-dependent and
-independent sectors. Although competitive in both sectors when the difference
in exposures is accounted for, a problem with fracturing of the detector gel
must be addressed before significantly larger exposures can be envisioned.Comment: revised and updated; accepted Astrop. Phy
WIMP searches with superheated droplet detectors: Status and Prospects
SIMPLE (Superheated Instrument for Massive ParticLE searches) employs
superheated droplet detectors (SDDs) to search for Weakly Interacting Massive
Particle (WIMP) dark matter. As a result of the intrinsic SDD insensitivity to
minimum ionizing particles and high fluorine content of target liquids,
competitive WIMP limits were already obtained at the early prototype stage. We
comment here on the expected immediate increase in sensitivity of the program
and on future plans to exploit this promising technnique.Comment: 6 pages LaTeX, incl. 2 figures. Presented at the 3rd Intl. Workshop
for the Identification of Dark Matter (IDM2000), York, Sept. 200
First Results of the Phase II SIMPLE Dark Matter Search
We report results of a 14.1 kgd measurement with 15 superheated droplet
detectors of total active mass 0.208 kg, comprising the first stage of a 30 kgd
Phase II experiment. In combination with the results of the neutron-spin
sensitive XENON10 experiment, these results yield a limit of |a_p| < 0.32 for
M_W = 50 GeV/c2 on the spin-dependent sector of weakly interacting massive
particle-nucleus interactions with a 50% reduction in the previously allowed
region of the phase space formerly defined by XENON, KIMS and PICASSO. In the
spin-independent sector, a limit of 2.3x10-5 pb at M_W = 45 GeV/c2 is obtained.Comment: 4 pages, 4 figures; PRL-accepted version with corrected SI contour
(Fig. 4
The SIMPLE Phase II Dark Matter Search
Phase II of SIMPLE (Superheated Instrument for Massive ParticLe Experiments)
searched for astroparticle dark matter using superheated liquid
CClF droplet detectors. Each droplet generally requires an energy
deposition with linear energy transfer (LET) 150 keV/m for a
liquid-to-gas phase transition, providing an intrinsic rejection against
minimum ionizing particles of order 10, and reducing the backgrounds to
primarily and neutron-induced recoil events. The droplet phase
transition generates a millimetric-sized gas bubble which is recorded by
acoustic means. We describe the SIMPLE detectors, their acoustic
instrumentation, and the characterizations, signal analysis and data selection
which yield a particle-induced, "true nucleation" event detection efficiency of
better than 97% at a 95% C.L. The recoil- event discrimination,
determined using detectors first irradiated with neutrons and then doped with
alpha emitters, provides a recoil identification of better than 99%; it differs
from those of COUPP and PICASSO primarily as a result of their different
liquids with lower critical LETs. The science measurements, comprising two
shielded arrays of fifteen detectors each and a total exposure of 27.77 kgd,
are detailed. Removal of the 1.94 kgd Stage 1 installation period data, which
had previously been mistakenly included in the data, reduces the science
exposure from 20.18 to 18.24 kgd and provides new contour minima of
= 4.3 10 pb at 35 GeV/c in the
spin-dependent sector of WIMP-proton interactions and = 3.6
10 pb at 35 GeV/c in the spin-independent sector. These
results are examined with respect to the fluorine spin and halo parameters used
in the previous data analysis.Comment: 20 pages, 19 figures; accepted Physical Review
Temporal trend of the first prescription of nevirapine: the ANRS CO3 Aquitaine Cohort, 1997-2008
International audiencen.
Viruses
We proposed a new HIV-1 therapeutic vaccine based on conserved cytotoxic T lymphocyte (CTL) epitopes of archived HIV-1 DNA according to their affinity to the dominant HLA-A and -B alleles of the population investigated. Our proposal (Hla Fitted VAC, HFVAC) was composed of 15 peptides originating from the RT, gag and nef parts of proviral DNA. Our aim was to investigate baseline immune reactivity to the vaccine in HIV-1 chronically infected patients at success of antiretroviral therapy (ART) who would be eligible for a therapeutic vaccine. Forty-one patients were tested. Most of them had been infected with HIV-1 subtype B and all had been receiving successful ART for 2 to 20 years. The predominant HLA-A and -B alleles were those of a Caucasian population. ELISPOT was carried out using the HFVAC peptides. In 22 patients, the PD-1 marker was investigated on CD4+ and CD8+ T cells by flow cytometry in order to evaluate global T cell exhaustion. ELISPOT positivity was 65% overall and 69% in patients exhibiting at least one HLA allele fitting with HFVAC. The percentages of CD4+ and CD8+ T cells expressing PD-1 were high (median values 23.70 and 32.60, respectively), but did not seem to be associated with an impairment of the immune response investigated in vitro. In conclusion, reactivity to HFVAC was high in this ART-treated population with dominant HLA alleles, despite potential cellular exhaustion associated with the PD-1 marker
CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: a longitudinal cohort study from COHERE.
BACKGROUND: Most adults infected with HIV achieve viral suppression within a year of starting combination antiretroviral therapy (cART). It is important to understand the risk of AIDS events or death for patients with a suppressed viral load.
METHODS AND FINDINGS: Using data from the Collaboration of Observational HIV Epidemiological Research Europe (2010 merger), we assessed the risk of a new AIDS-defining event or death in successfully treated patients. We accumulated episodes of viral suppression for each patient while on cART, each episode beginning with the second of two consecutive plasma viral load measurements 500 copies/µl, the first of two consecutive measurements between 50-500 copies/µl, cART interruption or administrative censoring. We used stratified multivariate Cox models to estimate the association between time updated CD4 cell count and a new AIDS event or death or death alone. 75,336 patients contributed 104,265 suppression episodes and were suppressed while on cART for a median 2.7 years. The mortality rate was 4.8 per 1,000 years of viral suppression. A higher CD4 cell count was always associated with a reduced risk of a new AIDS event or death; with a hazard ratio per 100 cells/µl (95% CI) of: 0.35 (0.30-0.40) for counts <200 cells/µl, 0.81 (0.71-0.92) for counts 200 to <350 cells/µl, 0.74 (0.66-0.83) for counts 350 to <500 cells/µl, and 0.96 (0.92-0.99) for counts ≥500 cells/µl. A higher CD4 cell count became even more beneficial over time for patients with CD4 cell counts <200 cells/µl.
CONCLUSIONS: Despite the low mortality rate, the risk of a new AIDS event or death follows a CD4 cell count gradient in patients with viral suppression. A higher CD4 cell count was associated with the greatest benefit for patients with a CD4 cell count <200 cells/µl but still some slight benefit for those with a CD4 cell count ≥500 cells/µl
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