The behavior of fatty acids in the blood plasma of monkeys following exposure to short term stresses

Monkeys exposed to short term stresses (immobilization, jealousy) were found to develop hyperlipacidemia with a rise in concentration of unsaturated fatty acids in blood plasma, especially of oleic acid, and a relative decrease of saturated free fatty acids, chiefly of palmitinic acid. This finding was more pronounced under immobilization stress than in the jealousy situation. Meanwhile, the composition of triglycerides did not change essentially under the conditions used

Research Notes : Inheritance of hardseededness in soybean

Soybean is often characterized by hardseededness or seed impermeability, when the seeds do not imbibe water and they germinate very slowly. Germination period of such seeds is very prolonged for a month or more. Hardseededness is caused by reduced water permeability of seed coat. We meet this character in many plant species, but more often in Leguminosae, Rosaceae, Lilium (Chorniy, 1980)

Moving lattice kinks and pulses: an inverse method

We develop a general mapping from given kink or pulse shaped travelling-wave solutions including their velocity to the equations of motion on one-dimensional lattices which support these solutions. We apply this mapping - by definition an inverse method - to acoustic solitons in chains with nonlinear intersite interactions, to nonlinear Klein-Gordon chains, to reaction-diffusion equations and to discrete nonlinear Schr\"odinger systems. Potential functions can be found in at least a unique way provided the pulse shape is reflection symmetric and pulse and kink shapes are at least $C^2$ functions. For kinks we discuss the relation of our results to the problem of a Peierls-Nabarro potential and continuous symmetries. We then generalize our method to higher dimensional lattices for reaction-diffusion systems. We find that increasing also the number of components easily allows for moving solutions.Comment: 15 pages, 5 figure

Spread Layers of Lysozyme Microgel at Liquid Surface

The spread layers of lysozyme (LYS) microgel particles were studied by surface dilational rheology, infrared reflection–absorption spectra, Brewster angle microscopy, atomic force microscopy, and scanning electron microscopy. It is shown that the properties of LYS microgel layers differ significantly from those of ß-lactoglobulin (BLG) microgel layers. In the latter case, the spread protein layer is mainly a monolayer, and the interactions between particles lead to the increase in the dynamic surface elasticity by up to 140 mN/m. In contrast, the dynamic elasticity of the LYS microgel layer does not exceed the values for pure protein layers. The compression isotherms also do not exhibit specific features of the layer collapse that are characteristic for the layers of BLG aggregates. LYS aggregates form trough three-dimensional clusters directly during the spreading process, and protein spherulites do not spread further along the interface. As a result, the liquid surface contains large, almost empty regions and some patches of high local concentration of the microgel particles

Structural and luminescent characteristics of YAG phosphors synthesized in the radiation field

YAG:Ce, YAGG:Ce ceramics were obtained by sintering the oxide powders in the radiation field. The results of investigations of the structure, composition and luminescence of ceramics are presented. The luminescence characteristics of powders exactly correspond to the phosphors luminescence used in practice obtained by solid-state synthesis methods. It has been established that in the used radiation exposure modes the main factor determining the efficiency of the synthesis is the ionization density

Critical behavior of the two-dimensional N-component Landau-Ginzburg Hamiltonian with cubic anisotropy

We study the two-dimensional N-component Landau-Ginzburg Hamiltonian with cubic anisotropy. We compute and analyze the fixed-dimension perturbative expansion of the renormalization-group functions to four loops. The relations of these models with N-color Ashkin-Teller models, discrete cubic models, planar model with fourth order anisotropy, and structural phase transition in adsorbed monolayers are discussed. Our results for N=2 (XY model with cubic anisotropy) are compatible with the existence of a line of fixed points joining the Ising and the O(2) fixed points. Along this line the exponent $\eta$ has the constant value 1/4, while the exponent $\nu$ runs in a continuous and monotonic way from 1 to $\infty$ (from Ising to O(2)). For N\geq 3 we find a cubic fixed point in the region $u, v \geq 0$, which is marginally stable or unstable according to the sign of the perturbation. For the physical relevant case of N=3 we find the exponents $\eta=0.17(8)$ and $\nu=1.3(3)$ at the cubic transition.Comment: 14 pages, 9 figure

MMP-28 as a regulator of myelination

<p>Abstract</p> <p>Background</p> <p>Matrix metalloproteinase-28 (MMP-28) is a poorly understood member of the matrix metalloproteinase family. Metalloproteinases are important mediators in the development of the nervous system and can contribute to the maturation of the neural micro-environment.</p> <p>Results</p> <p>MMP-28 added to myelinating rat dorsal root ganglion (DRG) co-cultures reduces myelination and two antibodies targeted to MMP-28 (pAb180 and pAb183) are capable of binding MMP-28 and inhibiting its activity in a dose-dependent manner. Addition of 30 nM pAb180 or pAb183 to rat DRG cultures resulted in the 2.6 and 4.8 fold enhancement of myelination respectively while addition of MMP-28 to DRG co-cultures resulted in enhanced MAPK, ErbB2 and ErbB3 phosphorylation. MMP-28 protein expression was increased within demyelinated lesions of mouse experimental autoimmune encephalitis (EAE) and human multiple sclerosis lesions compared to surrounding normal tissue.</p> <p>Conclusion</p> <p>MMP-28 is upregulated in conditions of demyelination in vivo, induces signaling in vitro consistent with myelination inhibition and, neutralization of MMP-28 activity can enhance myelination in vitro. These results suggest inhibition of MMP-28 may be beneficial under conditions of dysmyelination.</p

Structural and luminescent characteristics of YAG phosphors synthesized in the radiation field

YAG:Ce, YAGG:Ce ceramics were obtained by sintering the oxide powders in the radiation field. The results of investigations of the structure, composition and luminescence of ceramics are presented. The luminescence characteristics of powders exactly correspond to the phosphors luminescence used in practice obtained by solid-state synthesis methods. It has been established that in the used radiation exposure modes the main factor determining the efficiency of the synthesis is the ionization density

Integrin-mediated axoglial interactions initiate myelination in the central nervous system

All but the smallest-diameter axons in the central nervous system are myelinated, but the signals that initiate myelination are unknown. Our prior work has shown that integrin signaling forms part of the cell–cell interactions that ensure only those oligodendrocytes contacting axons survive. Here, therefore, we have asked whether integrins regulate the interactions that lead to myelination. Using homologous recombination to insert a single-copy transgene into the hypoxanthine phosphoribosyl transferase (hprt) locus, we find that mice expressing a dominant-negative β1 integrin in myelinating oligodendrocytes require a larger axon diameter to initiate timely myelination. Mice with a conditional deletion of focal adhesion kinase (a signaling molecule activated by integrins) exhibit a similar phenotype. Conversely, transgenic mice expressing dominant-negative β3 integrin in oligodendrocytes display no myelination abnormalities. We conclude that β1 integrin plays a key role in the axoglial interactions that sense axon size and initiate myelination, such that loss of integrin signaling leads to a delay in myelination of small-diameter axons