First-principles characterization of ferromagnetic Mn5Ge3 for spintronic applications

In the active search for potentially promising candidates for spintronic applications, we focus on the intermetallic ferromagnetic Mn5Ge3 compound and perform accurate first-principles FLAPW calculations within density functional theory. Through a careful investigation of the bulk electronic and magnetic structure, our results for the total magnetization, atomic magnetic moments, metallic conducting character and hyperfine fields are found to be in good agreement with experiments, and are elucidated in terms of a hybridization mechanism and exchange interaction. In order to assess the potential of this compound for spin-injection purposes, we calculate Fermi velocities and degree of spin-polarization; our results predict a rather high spin-injection efficiency in the diffusive regime along the hexagonal c-axis. Magneto-optical properties, such as L_2,3 X-ray magnetic circular dichroism, are also reported and await comparison with experimental data.Comment: 10 pages with 6 figures, to appear in Phys. Rev.

Sensory evaluation and electronic tongue for sensing grafted and non-grafted watermelon taste attributes

The objective of our study was to analyse the results of two measuring methods (sensory evaluation and electronic tongue) and to find differences in taste between grafted and non-grafted watermelon fruit. The trained sensory panel evaluated in two years three differently treated watermelon fruit. The studied fruit samples were produced on the same growing-areas in both years but with different growing technologies. The experiment used the non-grafted/self-rooted watermelon as control sample, while the other two treatments were grafting on two rootstock types: a Lagenaria and an interspecific squash hybrid rootstock. The electronic tongue measurement showed that it is the environment/growing technology that mainly determines the characteristics of the fruit quality, not grafting. The two measurement methods can complement each other in a detailed and practical way, as technology and growing area strongly influence the quality of watermelon fruit. The research also showed that it is possible to have similar watermelon fruit quality, independently from the used rootstock type

Example-based generation of graphical modelling environments

The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-42061-5_7Domain-Specific Languages (DSLs) present numerous benefits like powerful domain-specific primitives, an intuitive syntax for domain experts, and the possibility of advanced code generation for narrow domains. While a graphical syntax is sometimes desired for a DSL, constructing graphical modelling environments is a costly and highly technical task. This relegates domain experts to play a passive role in their development and hinders a wider adoption of graphical DSLs. Targeting a simpler DSL construction process, we propose an example based technique for the automatic generation of modelling environments for graphical DSLs. This way, starting from examples of the DSL likely provided by domain experts using drawing tools like yED, our system is able to synthesize a graphical modelling environment that mimics the syntax of the provided examples. This includes a meta-model for the abstract syntax of the DSL, and a graphical concrete syntax supporting spatial relationships like containment or attachment. The system is implemented as an Eclipse plugin, and we demonstrate its usage on a running example in the home networking domain.Work supported by the Spanish Ministry of Economy and Competitivity (TIN2014-52129-R), the Madrid Region (S2013/ICE-3006), and the EU Commission (FP7-ICT-2013-10, #611125)

TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice

Tissue inhibitor of metalloproteinase 3 (TIMP3) is an extracellular matrix (ECM) bound protein, which has been shown to be downregulated in human subjects and experimental models with cardiometabolic disorders, including type 2 diabetes mellitus, hypertension and atherosclerosis. The aim of this study was to investigate the effects of TIMP3 on cardiac energy homeostasis during increased metabolic stress conditions

Counting a black hole in Lorentzian product triangulations

We take a step toward a nonperturbative gravitational path integral for black-hole geometries by deriving an expression for the expansion rate of null geodesic congruences in the approach of causal dynamical triangulations. We propose to use the integrated expansion rate in building a quantum horizon finder in the sum over spacetime geometries. It takes the form of a counting formula for various types of discrete building blocks which differ in how they focus and defocus light rays. In the course of the derivation, we introduce the concept of a Lorentzian dynamical triangulation of product type, whose applicability goes beyond that of describing black-hole configurations.Comment: 42 pages, 11 figure

Taming the Shrew -Resolving Structural Heterogeneities with Hierarchical CPNs *

Abstract. Model transformations play a key role in the vision of ModelDriven Engineering (MDE) whereby the overcoming of structural heterogeneities, being a result of applying different meta-modeling constructs for the same semantic concept, is a challenging, recurring problem, urgently demanding for reuse of transformations. In this respect, an approach is required which (i) abstracts from the concrete execution language allowing to focus on the resolution of structural heterogeneities, (ii) keeps the impedance mismatch between specification and execution low enabling seamless debuggability, and (iii) provides formal underpinnings enabling model checking. Therefore, we propose to specify model transformations by applying a set of abstract mapping operators (MOPs), each resolving a certain kind of structural heterogeneity. For specifying the operational semantics of the MOPs, we propose to use Transformation Nets (TNs), a DSL on top of Colored Petri Nets (CPNs), since it allows (i) to keep the impedance mismatch between specification and execution low and (ii) to analyze model transformations by evaluating behavioral properties of CPNs

Target specificity among canonical nuclear poly(A) polymerases in plants modulates organ growth and pathogen response

Polyadenylation of pre-mRNAs is critical for efficient nuclear export, stability, and translation of the mature mRNAs, and thus for gene expression. The bulk of pre-mRNAs are processed by canonical nuclear poly(A) polymerase (PAPS). Both vertebrate and higher-plant genomes encode more than one isoform of this enzyme, and these are coexpressed in different tissues. However, in neither case is it known whether the isoforms fulfill different functions or polyadenylate distinct subsets of pre-mRNAs. Here we show that the three canonical nuclear PAPS isoforms in Arabidopsis are functionally specialized owing to their evolutionarily divergent C-terminal domains. A strong loss-of-function mutation in PAPS1 causes a male gametophytic defect, whereas a weak allele leads to reduced leaf growth that results in part from a constitutive pathogen response. By contrast, plants lacking both PAPS2 and PAPS4 function are viable with wild-type leaf growth. Polyadenylation of SMALL AUXIN UP RNA (SAUR) mRNAs depends specifically on PAPS1 function. The resulting reduction in SAUR activity in paps1 mutants contributes to their reduced leaf growth, providing a causal link between polyadenylation of specific pre-mRNAs by a particular PAPS isoform and plant growth. This suggests the existence of an additional layer of regulation in plant and possibly vertebrate gene expression, whereby the relative activities of canonical nuclear PAPS isoforms control de novo synthesized poly(A) tail length and hence expression of specific subsets of mRNAs