On the Temperature Dependence of the Casimir Effect

The temperature dependence of the Casimir force between a real metallic plate and a metallic sphere is analyzed on the basis of optical data concerning the dispersion relation of metals such as gold and copper. Realistic permittivities imply, together with basic thermodynamic considerations, that the transverse electric zero mode does not contribute. This results in observable differences with the conventional prediction, which does not take this physical requirement into account. The results are shown to be consistent with the third law of thermodynamics, as well as being consistent with current experiments. However, the predicted temperature dependence should be detectable in future experiments. The inadequacies of approaches based on {\it ad hoc} assumptions, such as the plasma dispersion relation and the use of surface impedance without transverse momentum dependence, are discussed.Comment: 14 pages, 3 eps figures, revtex4. New version includes clarifications and new reference. Accepted for publication in Phys. Rev.

Calculation of the Casimir Force between Similar and Dissimilar Metal Plates at Finite Temperature

The Casimir pressure is calculated between parallel metal plates, containing the materials Au, Cu, or Al. Our motivation for making this calculation is the need of comparing theoretical predictions, based on the Lifshitz formula, with experiments that are becoming gradually more accurate. In particular, the finite temperature correction is considered, in view of the recent discussion in the literature on this point. A special attention is given to the case where the difference between the Casimir pressures at two different temperatures, T=300 K and T=350 K, is involved. This seems to be a case that will be experimentally attainable in the near future, and it will be a critical test of the temperature correction.Comment: 23 latex pages, 12 figures. Introductory section expanded, 4 new references. To appear in J. Phys. A: Math. Ge

Casimir forces and non-Newtonian gravitation

The search for non-relativistic deviations from Newtonian gravitation can lead to new phenomena signalling the unification of gravity with the other fundamental interactions. Various recent theoretical frameworks indicate a possible window for non-Newtonian forces with gravitational coupling strength in the micrometre range. The major expected background in the same range is attributable to the Casimir force or variants of it if dielectric materials, rather than conducting ones, are considered. Here we review the measurements of the Casimir force performed so far in the micrometre range and how they determine constraints on non-Newtonian gravitation, also discussing the dominant sources of false signals. We also propose a geometry-independent parameterization of all data in terms of the measurement of the constant c. Any Casimir force measurement should lead, once all corrections are taken into account, to a determination of the constant c which, in order to assess the accuracy of the measurement, can be compared with its more precise value known through microscopic measurements. Although the last decade of experiments has resulted in solid demonstrations of the Casimir force, the situation is not conclusive with respect to being able to discover new physics. Future experiments and novel phenomenological analysis will be necessary to discover non-Newtonian forces or to push the window for their possible existence into regions of the parameter space which theoretically appear unnatural.Comment: Also available at http://www.iop.org/EJ/abstract/1367-2630/8/10/23

Casimir Force on Real Materials - the Slab and Cavity Geometry

We analyse the potential of the geometry of a slab in a planar cavity for the purpose of Casimir force experiments. The force and its dependence on temperature, material properties and finite slab thickness are investigated both analytically and numerically for slab and walls made of aluminium and teflon FEP respectively. We conclude that such a setup is ideal for measurements of the temperature dependence of the Casimir force. By numerical calculation it is shown that temperature effects are dramatically larger for dielectrics, suggesting that a dielectric such as teflon FEP whose properties vary little within a moderate temperature range, should be considered for experimental purposes. We finally discuss the subtle but fundamental matter of the various Green's two-point function approaches present in the literature and show how they are different formulations describing the same phenomenon.Comment: 24 pages, 11 figures; expanded discussion, one appendix added, 1 new figure and 10 new references. To appear in J. Phys. A: Math. Theo

Thermal corrections to the Casimir effect

The Casimir effect, reflecting quantum vacuum fluctuations in the electromagnetic field in a region with material boundaries, has been studied both theoretically and experimentally since 1948. The forces between dielectric and metallic surfaces both plane and curved have been measured at the 10 to 1 percent level in a variety of room-temperature experiments, and remarkable agreement with the zero-temperature theory has been achieved. In fitting the data various corrections due to surface roughness, patch potentials, curvature, and temperature have been incorporated. It is the latter that is the subject of the present article. We point out that, in fact, no temperature dependence has yet been detected, and that the experimental situation is still too fluid to permit conclusions about thermal corrections to the Casimir effect. Theoretically, there are subtle issues concerning thermodynamics and electrodynamics which have resulted in disparate predictions concerning the nature of these corrections. However, a general consensus has seemed to emerge that suggests that the temperature correction to the Casimir effect is relatively large, and should be observable in future experiments involving surfaces separated at the few micrometer scale.Comment: 21 pages, 9 eps figures, uses iopart.cls. Final version to be published in New Journal of Physics, contains Conclusion and clarified remark

Randomised clinical trial: individualised vs. weight-based dosing of azathioprine in Crohn's disease

Azathioprine (AZA), a pro-drug metabolized to the active metabolites 6-thioguanine nucleotides (6TGN), is a steroid-sparing therapy for Crohn’s disease (CD). This trial investigated whether AZA therapy is optimized by individualized dosing based on thiopurine methyltransferase (TPMT) activity and 6TGN concentrations

Seasonal-to-decadal predictions with the ensemble Kalman filter and the Norwegian Earth System Model: a twin experiment

Here, we firstly demonstrate the potential of an advanced flow dependent data assimilation method for performing seasonal-to-decadal prediction and secondly, reassess the use of sea surface temperature (SST) for initialisation of these forecasts. We use the Norwegian Climate Prediction Model (NorCPM), which is based on the Norwegian Earth System Model (NorESM) and uses the deterministic ensemble Kalman filter to assimilate observations. NorESM is a fully coupled system based on the Community Earth System Model version 1, which includes an ocean, an atmosphere, a sea ice and a land model. A numerically efficient coarse resolution version of NorESM is used. We employ a twin experiment methodology to provide an upper estimate of predictability in our model framework (i.e. without considering model bias) of NorCPM that assimilates synthetic monthly SST data (EnKF-SST). The accuracy of EnKF-SST is compared to an unconstrained ensemble run (FREE) and ensemble predictions made with near perfect (i.e. microscopic SST perturbation) initial conditions (PERFECT). We perform 10 cycles, each consisting of a 10-yr assimilation phase, followed by a 10-yr prediction. The results indicate that EnKF-SST improves sea level, ice concentration, 2 m atmospheric temperature, precipitation and 3-D hydrography compared to FREE. Improvements for the hydrography are largest near the surface and are retained for longer periods at depth. Benefits in salinity are retained for longer periods compared to temperature. Near-surface improvements are largest in the tropics, while improvements at intermediate depths are found in regions of large-scale currents, regions of deep convection, and at the Mediterranean Sea outflow. However, the benefits are often small compared to PERFECT, in particular, at depth suggesting that more observations should be assimilated in addition to SST. The EnKF-SST system is also tested for standard ocean circulation indices and demonstrates decadal predictability for Atlantic overturning and sub-polar gyre circulations, and heat content in the Nordic Seas. The system beats persistence forecast and shows skill for heat content in the Nordic Seas that is close to PERFECT

Sea Surface Temperature of the mid-Piacenzian Ocean:A Data-Model Comparison

The mid-Piacenzian climate represents the most geologically recent interval of long-term average warmth relative to the last million years, and shares similarities with the climate projected for the end of the 21st century. As such, it represents a natural experiment from which we can gain insight into potential climate change impacts, enabling more informed policy decisions for mitigation and adaptation. Here, we present the first systematic comparison of Pliocene sea surface temperature (SST) between an ensemble of eight climate model simulations produced as part of PlioMIP (Pliocene Model Intercomparison Project) with the PRISM (Pliocene Research, Interpretation and Synoptic Mapping) Project mean annual SST field. Our results highlight key regional and dynamic situations where there is discord between the palaeoenvironmental reconstruction and the climate model simulations. These differences have led to improved strategies for both experimental design and temporal refinement of the palaeoenvironmental reconstruction

Computer tomographic investigation of subcutaneous adipose tissue as an indicator of body composition

<p>Abstract</p> <p>Background</p> <p>Modern computer tomography (CT) equipment can be used to acquire whole-body data from large animals such as pigs in minutes or less. In some circumstances, computer assisted analysis of the resulting image data can identify and measure anatomical features. The thickness of subcutaneous adipose tissue at a specific site measured by ultrasound, is used in the pig industry to assess adiposity and inform management decisions that have an impact on reproduction, food conversion performance and sow longevity. The measurement site, called "P2", is used throughout the industry. We propose that CT can be used to measure subcutaneous adipose tissue thickness and identify novel measurement sites that can be used as predictors of general adiposity.</p> <p>Methods</p> <p>Growing pigs (<it>N </it>= 12), were each CT scanned on three occasions. From these data the total volume of adipose tissue was determined and expressed as a proportion of total volume (fat-index). A computer algorithm was used to determined 10,201 subcutaneous adipose thickness measurements in each pig for each scan. From these data, sites were selected where correlation with fat-index was optimal.</p> <p>Results</p> <p>Image analysis correctly identified the limits of the relevant tissues and automated measurements were successfully generated. Two sites on the animal were identified where there was optimal correlation with fat-index. The first of these was located 4 intercostal spaces cranial to the caudal extremity of the last rib, the other, a further 5 intercostal spaces cranially.</p> <p>Conclusion</p> <p>The approach to image analysis reported permits the creation of various maps showing adipose thickness or correlation of thickness with other variables by location on the surface of the pig. The method identified novel adipose thickness measurement positions that are superior (as predictors of adiposity) to the site which is in current use. A similar approach could be used in other situations to quantify potential links between subcutaneous adiposity and disease or production traits.</p