Determinants of individual dietary diversity score of children less than five years old in the southern zone of Tigray, Ethiopia

Dietary diversity is a measure of food consumption that reflects household access to a variety of foods and is also a proxy for  nutrient adequacy of the diet of  individuals. Dietary diversity is useful because it is correlated with nutrient intake as well as  various anthropometric measures in children. This study was carried out to assess the status of individual dietary diversity score (IDDS) of children under five years old (6-59 months) and its determinants in the Southern Zone of Tigray, Ethiopia. A survey of 320 households having children 6-59 months old was  conducted using a cross-sectional descriptive study with both qualitative and quantitative study designs following the FAO guidelines for the dietary diversity and a semi-structured questionnaire for  demographic and socio-economic factors. Data for the individual dietary diversity (IDDS) indicator were collected by asking the respondent (mother or caregiver) to recall the foods provided during the previous 24 hour period. Data analysis was conducted by using STATA 12 software. The mean IDDS in the study areas was found to be below four, which is the acceptable minimum level.  The traditional diet of children was cereal dominated and low in micronutrient rich food groups in all the assessed Kebeles1. Being a model2 farmer, household’s farmland endowment, female headship of the household, and experience in special meals preparation and participation in nutrition related training of household members were positively associated with dietary diversity of children in the study areas.In order to overcome the low IDDS of children in the areas and to improve their nutritional status through   consumption of diverse foods, it is important to make agricultural production more nutrition sensitive especially on diversification of nutrient dense agricultural products.Key words: Agriculture-Nutrition linkage, dietary diversity, food group, micronutrients, 24-hour recal

Assessment of Microfinance Loan Repayment Problems in the Informal Sector :( The Case of DECSI Mekelle Debub Sub Branch)

The aim of microcredit is to help the poor and lower income group to get funds for their business activities and to improve their lives. Usually, the loans given are very small, in short term period, no collateral needed and required monthly repayment. However, repayment problems become the main obstacle for the microcredit institutions to continue providing microcredit services.  This  is  because  most  of  the  microcredit  institutions  are  Non- Governmental Organizations (NGOs), where they received funds from the government and  donors and there are not profits oriented organizations. The investigation of various aspects  of credit default, whether it is random and influenced by erratic behavior or whether it is  influenced by certain factors in a specific situation  is a great important for both policy  makers and practitioners. Therefore, the major concern of this study was to assess the microfinance loan repayment problems in the informal sector of DECSI Mekelledebub sub branch.  This study is an attempt to assess, some of the main factors that influence microfinance level loan repayment performance of the informal sector. Data for the study was collected through a structured questionnaire and informal discussion with the experienced borrowers and higher officers of the sub branch. The collected data was analyzed using descriptive statistics and probit technique to ascertain those factors constraining repayment performance of microfinance credit. Results of the study indicate that better repayment performance is strongly and directly associated with Suitability of repayment period and educational level of the borrower. The institution should negotiate the time to repay the loan with its clients. That means, special attention must be given to this factor in order to improve the microfinance loan repayment and the institution should provide a specific loan class for the borrowers from higher institutions in addition to the group lending facility made by it.  Since most of the informal sector does not have any or little access to formal education.  Therefore, DECSI can increase its borrower’s repayment performance by creating conducive environment for education to the illiterates in cooperation with other NGO’s or government

Nutritional Status of Adolescent Girls from Rural Communities of Tigray, Northern Ethiopia

Background: Addressing the nutritional needs of adolescents could be an important step towards breaking the vicious cycle of intergenerational malnutrition. Objective: Assess nutritional status of rural adolescent girls. Design: Cross-sectional. Methods: Anthropometric and socio-demographic information from 211 adolescent girls representing 650 randomly selected households from thirteen communities in Tigray was used in data analysis. Height-for-age and BMI-for-age were compared to the 2007 WHO growth reference. Data were analyzed using SAS, Version 9.1. Results: None of the households reported access to adolescent micronutrient supplementation. The girls were shorter and thinner than the 2007 WHO reference population. The cross-sectional prevalence of stunting and thinness were 26.5% and 58.3%, respectively. Lack of latrine facilities was significantly associated with stunting (p = 0.0033) and thinness (p <0.0001). Age was strong predictor of stunting (r(2) = 0.8838, p <0.0001) and thinness (r(2) = 0.3324, p <0.0001). Conclusion: Undernutrition was prevalent among the girls. Strategies to improve the nutritional status of girls need to go beyond the conventional maternal and child health care programs to reach girls before conception to break the intergenerational cycle of malnutrition. Further, carefully designed longitudinal studies are needed to identify the reasons for poor growth throughout the period of adolescence in this population. [Ethiop. J. Health Dev. 2009; 23(1):5-11

Effect of Soil and Water Conservation on Rehabilitation of Degraded Lands and Crop Productivity in Maego Watershed, North Ethiopia

Many soil and water conservation (SWC) measures were undertaken to decrease land degradation in Ethiopia. However, evaluation of their performance is essential to understand their success or failure and readjusting accordingly in the future planning. Therefore, the objective of this study was to evaluate effectiveness of SWC measures in rehabilitation of degraded watershed and increase crop productivity in Maego watershed, Ethiopia. Seventy six sample plots were randomly taken from treated and untreated sub-watersheds for woody species and soil sampling. Crops yield was measured on top side, middle zone and below side of SWC structures. There were significantly higher woody species density and diversity, total nitrogen (TN), soil organic matter (SOM) and soil moisture in the treated uncultivated land than the untreated one. The highest tree and sapling species density and diversity, TN and SOM were recorded on the exclosure part of the treated sub-watershed. Landscape position affected soil fertility, but has no effect on woody species density and diversity. The highest barley and wheat yield was measured on top side of SWC structures. Therefore, physical SWC structures should be integrated with exclosure to enhance rehabilitation of degraded watersheds/landscapes. Integration of biological SWC measures that improve soil fertility are essential on the cultivated land of the watershed. Most of the existing SWC structures, especially the old ones are filled with accumulated sediment, so maintenance is needed

Micro water harvesting for climate change mitigation: Trade-offs between health and poverty reduction in Northern Ethiopia

Water harvesting is an important tool for mitigating the adverse effects of climate change. This report investigates the trade-offs between health and poverty reduction by considering the impacts of water harvesting on health in Tigray region, northern Ethiopia. In particular, we assess the prevalence of malaria in association with ponds and wells. Moreover, the determinants of malaria incidence are explored with multivariate analysis. Additionally, we investigate people¿s willingness to pay (WTP) for improved malaria control using a contingent valuation method (CVM). In particular, we applied a double-bounded dichotomous choice CV surveys to elicit households¿ WTP for improved health services to control malaria. With interval regression, the WTP was explained as a function of household characteristics, health and health service conditions, and village level factors. The malaria prevalence rate is very high, more than 30 percent in low land communities, although rates are higher after rainy season. This suggests that ponds and wells are important factors in determining the prevalence of malaria. Better conditions of housing and toilet type, availability of bed nets reduce incidence. Pond and well ownership affects the WTP for improved malaria control in a negative and positive way respectively indicating differences in their economic attractiveness. WTP decreases with altitude and thus malaria incidence. Education and household asset holding generally increases WTP for improved health services. The results suggest that valuation results on household¿s WTP in poor economies may be underestimated because of cash constraint. Consequently, alternative payment vehicles in eliciting households¿ WTP have to be considered. Similarly, the estimated mean WTP for the external health cost of wells and ponds may be underestimated. In our case, ponds and wells are not fully exploited, as our results suggest that they do not contribute to household income or welfare. In that case, the presence of ponds and wells pose high external costs to the econom

Frequent use of paracetamol and risk of allergic disease among women in an Ethiopian population

Introduction The hypothesis that paracetamol might increase the risk of asthma and other allergic diseases have gained support from a range of independent studies. However, in studies based in developed countries, the possibility that paracetamol and asthma are associated through aspirin avoidance is difficult to exclude. Objectives To explore this hypothesis among women in a developing country, where we have previously reported aspirin avoidance to be rare. Methods In 2005/6 a population based cohort of 1065 pregnant women was established in Butajira, Ethiopia and baseline demographic data collected. At 3 years post birth, an interview-based questionnaire administered to 945 (94%) of these women collected data on asthma, eczema, and hay fever in the past 12 month, frequency of paracetamol use and potential confounders. Allergen skin tests to Dermatophagoides pteronyssinus and cockroach were also performed. The independent effects of paracetamol use on allergic outcomes were determined using multiple logistic regression analysis. Findings The prevalence of asthma, eczema and hay fever was 1.7%, 0.9% and 3.8% respectively; of any one of these conditions 5.5%, and of allergen sensitization 7.8%. Paracetamol use in the past month was reported by 29%, and associations of borderline significance were seen for eczema (adjusted OR (95% CI) = 8.51 (1.68 to 43.19) for 1–3 tablets and 2.19 (0.36 to 13.38) for ≥4 tablets, compared to no tablets in the past month; overall p = 0.055) and for ‘any allergic condition’ (adjusted OR (95% CI) = 2.73 (1.22 to 6.11) for 1–3 tablets and 1.35 (0.67 to 2.70) for ≥4 tablets compared to 0 in the past month; overall p = 0.071). Conclusions This study provides further cross-sectional evidence that paracetamol use increases the risk of allergic disease

Inhibition of CDK9 activity compromises global splicing in prostate cancer cells

Cyclin-dependent kinase 9 (CDK9) phosphorylates RNA polymerase II to promote productive transcription elongation. Here we show that short-term CDK9 inhibition affects the splicing of thousands of mRNAs. CDK9 inhibition impairs global splicing and there is no evidence for a coordinated response between the alternative splicing and the overall transcriptome. Alternative splicing is a feature of aggressive prostate cancer (CRPC) and enables the generation of the anti-androgen resistant version of the ligand-independent androgen receptor, AR-v7. We show that CDK9 inhibition results in the loss of AR and AR-v7 expression due to the defects in splicing, which sensitizes CRPC cells to androgen deprivation. Finally, we demonstrate that CDK9 expression increases as PC cells develop CRPC-phenotype both in vitro and also in patient samples. To conclude, here we show that CDK9 inhibition compromises splicing in PC cells, which can be capitalized on by targeting the PC-specific addiction androgen receptor.Peer reviewe

Challenges and opportunities for implementing integrated mental health care: a district level situation analysis from five low- and middle-income countries.

BACKGROUND: Little is known about how to tailor implementation of mental health services in low- and middle-income countries (LMICs) to the diverse settings encountered within and between countries. In this paper we compare the baseline context, challenges and opportunities in districts in five LMICs (Ethiopia, India, Nepal, South Africa and Uganda) participating in the PRogramme for Improving Mental health carE (PRIME). The purpose was to inform development and implementation of a comprehensive district plan to integrate mental health into primary care. METHODS: A situation analysis tool was developed for the study, drawing on existing tools and expert consensus. Cross-sectional information obtained was largely in the public domain in all five districts. RESULTS: The PRIME study districts face substantial contextual and health system challenges many of which are common across sites. Reliable information on existing treatment coverage for mental disorders was unavailable. Particularly in the low-income countries, many health service organisational requirements for mental health care were absent, including specialist mental health professionals to support the service and reliable supplies of medication. Across all sites, community mental health literacy was low and there were no models of multi-sectoral working or collaborations with traditional or religious healers. Nonetheless health system opportunities were apparent. In each district there was potential to apply existing models of care for tuberculosis and HIV or non-communicable disorders, which have established mechanisms for detection of drop-out from care, outreach and adherence support. The extensive networks of community-based health workers and volunteers in most districts provide further opportunities to expand mental health care. CONCLUSIONS: The low level of baseline health system preparedness across sites underlines that interventions at the levels of health care organisation, health facility and community will all be essential for sustainable delivery of quality mental health care integrated into primary care