Book Review

A. Funston, M. Gil & G. Gilmore (Eds). (2014). Strong starts, supportedtransitions and student success. UK: Cambridge Scholars Publishing.Reviewed by Birgit Schreiber

Prostate Cancer in Primary Care

This is the final version of the article. Available from Springer Verlag via the DOI in this record.Prostate cancer is a common malignancy seen worldwide. The incidence has risen in recent decades, mainly fuelled by more widespread use of prostate-specific antigen (PSA) testing, although prostate cancer mortality rates have remained relatively static over that time period. A man's risk of prostate cancer is affected by his age and family history of the disease. Men with prostate cancer generally present symptomatically in primary care settings, although some diagnoses are made in asymptomatic men undergoing opportunistic PSA screening. Symptoms traditionally thought to correlate with prostate cancer include lower urinary tract symptoms (LUTS), such as nocturia and poor urinary stream, erectile dysfunction and visible haematuria. However, there is significant crossover in symptoms between prostate cancer and benign conditions affecting the prostate such as benign prostatic hypertrophy (BPH) and prostatitis, making it very challenging to distinguish between them on the basis of symptoms. The evidence for the performance of PSA in asymptomatic and symptomatic men for the diagnosis of prostate cancer is equivocal. PSA is subject to false positive and false negative results, affecting its clinical utility as a standalone test. Clinicians need to counsel men about the risks and benefits of PSA testing to inform their decision-making. Digital rectal examination (DRE) by primary care clinicians has some evidence to show discrimination between benign and malignant conditions affecting the prostate. Patients referred to secondary care for diagnostic testing for prostate cancer will typically undergo a transrectal or transperineal biopsy, where a number of samples are taken and sent for histological examination. These biopsies are invasive procedures with side effects and a risk of infection and sepsis, and alternative tests such as multiparametric magnetic resonance imaging (mpMRI) are currently being trialled for their accuracy and safety in diagnosing clinically significant prostate cancer

Effects of Supplemental Energy and Protein Source on Performance of Steers Grazing Irrigated Corn Residue

Steer calves grazing corn residue (86 d) were assigned to 1 of 5 treatments to evaluate the effects of protein and energy supplements on steer performance. Th e 5 treatments consisted of 1) un-supplemented control (NS), 2) dry rolled corn only (CRN), 3) 89% dry rolled corn/6% molasses/5% urea (C + RDP), 4) 60/40 blend of soy- pass/soybean meal (SP), and 5) dried distillers grains plus solubles (DGS). Supplements were fed to provide equal TDN intake. Average daily gain among treatments was 1.48, 1.32, 0.53, 0.31, and −0.18 lbs. for SP, DGS, C + RDP, CRN, and NS, respectively. Only steers fed SP and DGS produced over- winter gains greater than 1 lb/d, suggesting metabolizable protein requirements must be met for growing calves to utilize residue efficiently

Improving the Timely Detection of Bladder and Kidney Cancer in Primary Care

Bladder and kidney cancer are the 10th and 7th most common cancers in the United Kingdom (UK). They present with symptoms that are typically investigated via the same diagnostic pathway. However, diagnosing these cancers can be challenging, especially for kidney cancer, as many of the symptoms are non-specific and occur commonly in patients without cancer. Furthermore, the recognition and evaluation of these symptoms may differ because of the lack of supporting high-quality evidence to inform management, a problem also reflected in currently ambiguous guidelines. The majority of these two cancers are diagnosed following a referral from a general practitioner. In this article, we summarise current UK and United States (US) guidelines for investigating common symptoms of bladder and kidney cancer-visible haematuria, non-visible haematuria and urinary tract infections. Our article aims to support clinicians in recognising and investigating patients with symptoms of possible bladder and kidney cancer in a timely fashion. We discuss challenges during the diagnostic process and possible future interventions for improvement

Risk of fractures in half a million survivors of 20 cancers: a population-based matched cohort study using linked English electronic health records.

BACKGROUND: A history of multiple myeloma, prostate cancer, and breast cancer has been associated with adverse bone health, but associations across a broader range of cancers are unclear. We aimed to compare the risk of any bone fracture and major osteoporotic fractures in survivors of a wide range of cancers versus cancer-free individuals. METHODS: In this population-based matched cohort study, we used electronic health records from the UK Clinical Practice Research Datalink linked to hospital data. We included adults (aged ≥18 years) eligible for linkage, and we restricted the study start to Jan 2, 1998, onwards and applied administrative censoring on Jan 31, 2020. The cancer survivor group included survivors of the 20 most common cancers. Each individual with cancer was matched (age, sex, and general practice) to up to five controls (1:5) who were cancer-free. The primary outcomes were any bone fracture and any major osteoporotic fracture (pelvic, hip, wrist, spine, or proximal humeral fractures) occurring more than 1 year after index date (ie, the diagnosis date of the matched individual with cancer). We used Cox regression models, adjusted for shared risk factors, to estimate associations between cancer survivorship and bone fractures. FINDINGS: 578 160 adults with cancer diagnosed in 1998-2020 were matched to 3 226 404 cancer-free individuals. Crude incidence rates of fractures in cancer survivors ranged between 8·39 cases (95% CI 7·45-9·46) per 1000 person-years for thyroid cancer and 21·62 cases (20·18-23·18) per 1000 person-years for multiple myeloma. Compared with cancer-free individuals, the risk of any bone fracture was increased in 15 of 20 cancers, and of major osteoporotic fractures in 17 of 20 cancers. Effect sizes varied: adjusted hazard ratios (HRs) were largest for multiple myeloma (1·94, 95% CI 1·77-2·13) and prostate cancer (1·43, 1·39-1·47); HRs in the range 1·20-1·50 were seen for stomach, liver, pancreas, lung, breast, kidney, and CNS cancers; smaller associations (HR <1·20) were observed for malignant melanoma, non-Hodgkin lymphoma, leukaemia, and oesophageal, colorectal, and cervical cancers. Increased risks of major osteoporotic fracture were noted most substantially in multiple myeloma (2·25, 1·96-2·58) and CNS (2·12, 1·56-2·87), liver (1·62, 1·01-2·61), prostate (1·60, 1·53-1·67), and lung cancers (1·60, 1·44-1·77). Effect sizes tended to reduce over time since diagnosis but remained elevated for more than 5 years in several cancers, such as multiple myeloma and stomach, lung, breast, prostate, and CNS cancers. INTERPRETATION: Survivors of most types of cancer were at increased risk of bone fracture for several years after cancer, with variation by cancer type. These findings can help to inform mitigation and prevention strategies. FUNDING: Wellcome Trust

Carcass Gain, Efficiency, and Profitability of Steers at Extended Days on Feed

Steers were individually fed for 22 and 44 days longer than the industry average marketing point of 0.5” backfat to determine carcass- based gain, efficiency, and deposition changes throughout the feeding period (142, 163, and 184 days on feed). Premiums and discounts for yield grade, quality grade, and overweight carcasses were applied to determine profitability. Feeding steers for 22 and 44 days longer increased carcass weight, quality grade, and yield grade 4 and 5s. Steers fed 44 days longer had increased total revenue and profit per head despite a decrease in live gain and efficiency

The status of cheetah and African wild dog in the Benoue Ecosystem, North Cameroon

Conservation Biology - ol

Influence of Maternal Protein Restriction in Primiparous Heifers During Mid- and/or Late-gestation on Dam and Suckling Calf Performance

Nutrient status in gestating beef cows has been shown to impact performance of the dam and offspring; however, most research has focused on energy or a total diet restriction and a single period of gestation. The objective of this study was to evaluate the effects of maternal metabolizable protein (MP) restriction in primiparous heifers during mid- and/or late gestation on dam and suckling calf performance through weaning

Influence of Maternal Protein Restriction in Primiparous Heifers During Mid- and/or Late Gestation on Progeny Feedlot Performance and Carcass Characteristics

Maternal nutrient restriction in beef cows impacts developmental processes in the fetus that may influence lifetime performance. This study investigated impacts of metabolizable protein (MP) restriction in primiparous heifers during mid- and/or late-gestation on progeny feedlot performance and carcass characteristics