1,146 research outputs found
Locomotor activation induced by infusion of endorphins into the ventral tegmental area: evidence for opiate-dopamine interactions.
Assessing Internet addiction using the parsimonious Internet addiction components model - a preliminary study [forthcoming]
Internet usage has grown exponentially over the last decade. Research indicates that excessive Internet use can lead to symptoms associated with addiction. To date, assessment of potential Internet addiction has varied regarding populations studied and instruments used, making reliable prevalence estimations difficult. To overcome the present problems a preliminary study was conducted testing a parsimonious Internet addiction components model based on Griffiths’ addiction components (2005), including salience, mood modification, tolerance, withdrawal, conflict, and relapse. Two validated measures of Internet addiction were used (Compulsive Internet Use Scale [CIUS], Meerkerk et al., 2009, and Assessment for Internet and Computer Game Addiction Scale [AICA-S], Beutel et al., 2010) in two independent samples (ns = 3,105 and 2,257). The fit of the model was analysed using Confirmatory Factor Analysis. Results indicate that the Internet addiction components model fits the data in both samples well. The two sample/two instrument approach provides converging evidence concerning the degree to which the components model can organize the self-reported behavioural components of Internet addiction. Recommendations for future research include a more detailed assessment of tolerance as addiction component
Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization
Dynorphins, endogenous opioid peptides that arise from the precursor protein prodynorphin (Pdyn), are hypothesized to be involved in the regulation of mood states and the neuroplasticity associated with addiction. The current study tested the hypothesis that dynorphin in the nucleus accumbens (NAcc) mediates such effects. More specifically, we examined whether knockdown of Pdyn within the NAcc in rats would alter the expression of depressive-like and anxiety-like behavior, as well as cocaine locomotor sensitization. Wistar rats were injected with adeno-associated viral (AAV) vectors encoding either a Pdyn-specific short hairpin RNA (AAV-shPdyn) or a scrambled shRNA (AAV-shScr) as control. Four weeks later, rats were tested for anxiety-like behavior in the elevated plus maze test and depressive-like behavior in the forced swim test (FST). Finally, rats received one daily injection of saline or cocaine (20 mg/kg, i.p.), followed by assessment of locomotion for 4 consecutive days. Following 3 days of abstinence, the rats completed 2 additional daily cocaine/saline locomotor trials. Pdyn knockdown in the NAcc led to a significant reduction in depressive-like behavior in the FST, but had no effect on anxiety-like behavior in the elevated plus maze. Pdyn knockdown did not alter baseline locomotor behavior, the locomotor response to acute cocaine, or the initial sensitization of the locomotor response to cocaine over the first 4 cocaine treatment days. However, following 3 days abstinence the locomotor response to the cocaine challenge returned to their original levels in the AAV-shPdyn rats while remaining heightened in the AAV-shScr rats. These results suggest that dynorphin in a very specific area of the nucleus accumbens contributes to depressive-like states and may be involved in neuroadaptations in the NAcc that contribute to the development of cocaine addiction as a persistent and lasting condition
Search for Dark Matter Annihilation in the Galactic Center with IceCube-79
The Milky Way is expected to be embedded in a halo of dark matter particles,
with the highest density in the central region, and decreasing density with the
halo-centric radius. Dark matter might be indirectly detectable at Earth
through a flux of stable particles generated in dark matter annihilations and
peaked in the direction of the Galactic Center. We present a search for an
excess flux of muon (anti-) neutrinos from dark matter annihilation in the
Galactic Center using the cubic-kilometer-sized IceCube neutrino detector at
the South Pole. There, the Galactic Center is always seen above the horizon.
Thus, new and dedicated veto techniques against atmospheric muons are required
to make the southern hemisphere accessible for IceCube. We used 319.7 live-days
of data from IceCube operating in its 79-string configuration during 2010 and
2011. No neutrino excess was found and the final result is compatible with the
background. We present upper limits on the self-annihilation cross-section,
\left, for WIMP masses ranging from 30 GeV up to
10 TeV, assuming cuspy (NFW) and flat-cored (Burkert) dark matter halo
profiles, reaching down to cm s, and
cm s for the
channel, respectively.Comment: 14 pages, 9 figures, Submitted to EPJ-C, added references, extended
limit overvie
Morphological analysis and description of the ovaries of female silky sharks, Carcharhinus falciformis (Müller & Henle, 1839)
This work aims to study the female reproductive tract of silky sharks, Carcharhinus falciformis, captured in the South and
Equatorial Atlantic Ocean. Samples were collected between January 2008 and March 2010 through oceanic commercial vessels
that targeted tuna and swordfish, with a total of 17 females collected. The methodologies followed for analyzing the ovaries
of those females included both macroscopic and histological analysis. Macroscopically, it was possible to determine that the
ovaries on these sharks is suspended by mesenteries in the anterior section of the body cavity, heavily irrigated by blood
vessels, and contains a wide range of oocytes. Ovaries were found in three distinct maturational stages: Stage I (Immature),
Stage II (Maturing) and Stage III (Mature). Immature ovaries were small, with widths ranging from 1.0 to 3.1 cm, and had a
gelatinous or granulose internal structure; maturing ovaries were slightly larger, ranging in width between 5.2 and 6.0 cm;
mature ovaries ranged in width between 6.5 and 7.8 cm, and had a more rounded shape and the presence of large and well
developed oocytes. Under microscopic examination, it was observed that the ovaries were covered with simple epithelial
tissue during the early development stages and a simple cubic epithelium in the final stages of maturation. During the initial
maturation stages the epigonal organ was not differentiated from the ovary. In mature specimens, the ovary showed a simple
cubic epithelium and just below this epithelium there was a layer of dense connective tissue and muscle with the presence of
vitellogenic oocytes and fat cells. A thin yolk membrane enclosing the oocytes was also evident. Finally, it was possible to
distinguish a zona pellucida, separating the oocytes from the follicle wall and a basal lamina between the granular layers and
the teak layer.info:eu-repo/semantics/publishedVersio
The IceCube Neutrino Observatory - Contributions to ICRC 2015 Part II: Atmospheric and Astrophysical Diffuse Neutrino Searches of All Flavors
Papers on atmospheric and astrophysical diffuse neutrino searches of all
flavors submitted to the 34th International Cosmic Ray Conference (ICRC 2015,
The Hague) by the IceCube Collaboration.Comment: 66 pages, 36 figures, Papers submitted to the 34th International
Cosmic Ray Conference, The Hague 2015, v2 has a corrected author lis
A combined maximum-likelihood analysis of the high-energy astrophysical neutrino flux measured with IceCube
Evidence for an extraterrestrial flux of high-energy neutrinos has now been
found in multiple searches with the IceCube detector. The first solid evidence
was provided by a search for neutrino events with deposited energies
TeV and interaction vertices inside the instrumented volume. Recent
analyses suggest that the extraterrestrial flux extends to lower energies and
is also visible with throughgoing, -induced tracks from the Northern
hemisphere. Here, we combine the results from six different IceCube searches
for astrophysical neutrinos in a maximum-likelihood analysis. The combined
event sample features high-statistics samples of shower-like and track-like
events. The data are fit in up to three observables: energy, zenith angle and
event topology. Assuming the astrophysical neutrino flux to be isotropic and to
consist of equal flavors at Earth, the all-flavor spectrum with neutrino
energies between 25 TeV and 2.8 PeV is well described by an unbroken power law
with best-fit spectral index and a flux at 100 TeV of
.
Under the same assumptions, an unbroken power law with index is disfavored
with a significance of 3.8 () with respect to the best
fit. This significance is reduced to 2.1 () if instead we
compare the best fit to a spectrum with index that has an exponential
cut-off at high energies. Allowing the electron neutrino flux to deviate from
the other two flavors, we find a fraction of at Earth.
The sole production of electron neutrinos, which would be characteristic of
neutron-decay dominated sources, is rejected with a significance of 3.6
().Comment: 16 pages, 10 figures; accepted for publication in The Astrophysical
Journal; updated one referenc
Determining neutrino oscillation parameters from atmospheric muon neutrino disappearance with three years of IceCube DeepCore data
We present a measurement of neutrino oscillations via atmospheric muon
neutrino disappearance with three years of data of the completed IceCube
neutrino detector. DeepCore, a region of denser instrumentation, enables the
detection and reconstruction of atmospheric muon neutrinos between 10 GeV and
100 GeV, where a strong disappearance signal is expected. The detector volume
surrounding DeepCore is used as a veto region to suppress the atmospheric muon
background. Neutrino events are selected where the detected Cherenkov photons
of the secondary particles minimally scatter, and the neutrino energy and
arrival direction are reconstructed. Both variables are used to obtain the
neutrino oscillation parameters from the data, with the best fit given by
and
(normal mass hierarchy assumed). The
results are compatible and comparable in precision to those of dedicated
oscillation experiments.Comment: 10 pages, 7 figure
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