640 research outputs found
Generalized compactness in linear spaces and its applications
The class of subsets of locally convex spaces called -compact sets is
considered. This class contains all compact sets as well as several noncompact
sets widely used in applications. It is shown that many results well known for
compact sets can be generalized to -compact sets. Several examples are
considered.
The main result of the paper is a generalization to -compact convex sets
of the Vesterstrom-O'Brien theorem showing equivalence of the particular
properties of a compact convex set (s.t. openness of the mixture map, openness
of the barycenter map and of its restriction to maximal measures, continuity of
a convex hull of any continuous function, continuity of a convex hull of any
concave continuous function). It is shown that the Vesterstrom-O'Brien theorem
does not hold for pointwise -compact convex sets defined by the slight
relaxing of the -compactness condition. Applications of the obtained
results to quantum information theory are considered.Comment: 27 pages, the minor corrections have been mad
Novel coumarins active against Trypanosoma cruzi and toxicity assessment using the animal model Caenorhabditis elegans
From 2nd Latin American Congress of Clinical and Laboratorial Toxicology
Porto Alegre, Brazil. 3-6 June 2018Background: Chagas disease (CD) is a tropical parasitic disease. Although the number of people infected is very
high, the only drugs available to treat CD, nifurtimox (Nfx) and benznidazole, are highly toxic, particularly in the
chronic stage of the disease. Coumarins are a large class of compounds that display a wide range of interesting
biological properties, such as antiparasitic. Hence, the aim of this work is to find a good antitrypanosomal drug with less toxicity. The use of simple organism models has become increasingly attractive for planning and simplifying efficient drug discovery. Within these models, Caenorhabditis elegans has emerged as a convenient and versatile tool with significant advantages for the toxicological potential identification for new compounds. Methods: Trypanocidal activity: Forty-two 4-methylamino-coumarins were assayed against the epimastigote form of Trypanosoma cruzi (Tulahuen 2 strain) by inhibitory concentration 50% (IC50). Toxicity assays: Lethal dose 50% (LD50) and Body Area were determined by Caenorhabditis elegans N2 strain (wild type) after acute exposure. Structure-activity relationship: A classificatory model was built using 3D descriptors. Results: Two of these coumarins demonstrated near equipotency to Nifurtimox (IC50 = 5.0 ± 1 μM), with values of:
11 h (LaSOM 266), (IC50 = 6.4 ± 1 μM) and 11 g (LaSOM 231), (IC50 = 8.2 ± 2.3 μM). In C. elegans it was possible to observe that Nfx showed greater toxicity in both the LD50 assay and the evaluation of the development of worms. It is possible to observe that the efficacy between Nfx and the synthesized compounds (11 h and 11 g) are similar. On the other hand, the toxicity of Nfx is approximately three times higher than that of the compounds. Results from the QSAR-3D study indicate that the volume and hydrophobicity of the substituents have a significant impact on the trypanocidal activities for derivatives that cause more than 50% of inhibition. These results show that the C. elegans model is efficient for screening potentially toxic compounds. Conclusion: Two coumarins (11 h and 11 g) showed activity against T. cruzi epimastigote similar to Nifurtimox, however with lower toxicity in both LD50 and development of C. elegans assays. These two compounds may be a feasible starting point for the development of new trypanocidal drugs
Astrometric calibration and performance of the Dark Energy Camera
We characterize the ability of the Dark Energy Camera (DECam) to perform
relative astrometry across its 500~Mpix, 3 deg^2 science field of view, and
across 4 years of operation. This is done using internal comparisons of ~4x10^7
measurements of high-S/N stellar images obtained in repeat visits to fields of
moderate stellar density, with the telescope dithered to move the sources
around the array. An empirical astrometric model includes terms for: optical
distortions; stray electric fields in the CCD detectors; chromatic terms in the
instrumental and atmospheric optics; shifts in CCD relative positions of up to
~10 um when the DECam temperature cycles; and low-order distortions to each
exposure from changes in atmospheric refraction and telescope alignment. Errors
in this astrometric model are dominated by stochastic variations with typical
amplitudes of 10-30 mas (in a 30 s exposure) and 5-10 arcmin coherence length,
plausibly attributed to Kolmogorov-spectrum atmospheric turbulence. The size of
these atmospheric distortions is not closely related to the seeing. Given an
astrometric reference catalog at density ~0.7 arcmin^{-2}, e.g. from Gaia, the
typical atmospheric distortions can be interpolated to 7 mas RMS accuracy (for
30 s exposures) with 1 arcmin coherence length for residual errors. Remaining
detectable error contributors are 2-4 mas RMS from unmodelled stray electric
fields in the devices, and another 2-4 mas RMS from focal plane shifts between
camera thermal cycles. Thus the astrometric solution for a single DECam
exposure is accurate to 3-6 mas (0.02 pixels, or 300 nm) on the focal plane,
plus the stochastic atmospheric distortion.Comment: Submitted to PAS
Quasar accretion disk sizes from continuum reverberation mapping in the DES standard-star fields
Measurements of the physical properties of accretion disks in active galactic
nuclei are important for better understanding the growth and evolution of
supermassive black holes. We present the accretion disk sizes of 22 quasars
from continuum reverberation mapping with data from the Dark Energy Survey
(DES) standard star fields and the supernova C fields. We construct continuum
lightcurves with the \textit{griz} photometry that span five seasons of DES
observations. These data sample the time variability of the quasars with a
cadence as short as one day, which corresponds to a rest frame cadence that is
a factor of a few higher than most previous work. We derive time lags between
bands with both JAVELIN and the interpolated cross-correlation function method,
and fit for accretion disk sizes using the JAVELIN Thin Disk model. These new
measurements include disks around black holes with masses as small as
, which have equivalent sizes at 2500\AA \, as small as
light days in the rest frame. We find that most objects have
accretion disk sizes consistent with the prediction of the standard thin disk
model when we take disk variability into account. We have also simulated the
expected yield of accretion disk measurements under various observational
scenarios for the Large Synoptic Survey Telescope Deep Drilling Fields. We find
that the number of disk measurements would increase significantly if the
default cadence is changed from three days to two days or one day.Comment: 33 pages, 24 figure
Photometric redshifts and clustering of emission line galaxies selected jointly by DES and eBOSS
We present the results of the first test plates of the extended Baryon
Oscillation Spectroscopic Survey. This paper focuses on the emission line
galaxies (ELG) population targetted from the Dark Energy Survey (DES)
photometry. We analyse the success rate, efficiency, redshift distribution, and
clustering properties of the targets. From the 9000 spectroscopic redshifts
targetted, 4600 have been selected from the DES photometry. The total success
rate for redshifts between 0.6 and 1.2 is 71\% and 68\% respectively for a
bright and faint, on average more distant, samples including redshifts measured
from a single strong emission line. We find a mean redshift of 0.8 and 0.87,
with 15 and 13\% of unknown redshifts respectively for the bright and faint
samples. In the redshift range 0.6<z<1.2, for the most secure spectroscopic
redshifts, the mean redshift for the bright and faint sample is 0.85 and 0.9
respectively. Star contamination is lower than 2\%. We measure a galaxy bias
averaged on scales of 1 and 10~Mpc/h of 1.72 \pm 0.1 for the bright sample and
of 1.78 \pm 0.12 for the faint sample. The error on the galaxy bias have been
obtained propagating the errors in the correlation function to the fitted
parameters. This redshift evolution for the galaxy bias is in agreement with
theoretical expectations for a galaxy population with MB-5\log h < -21.0. We
note that biasing is derived from the galaxy clustering relative to a model for
the mass fluctuations. We investigate the quality of the DES photometric
redshifts and find that the outlier fraction can be reduced using a comparison
between template fitting and neural network, or using a random forest
algorithm
Chemical Abundance Analysis of Tucana III, the Second -process Enhanced Ultra-Faint Dwarf Galaxy
We present a chemical abundance analysis of four additional confirmed member
stars of Tucana III, a Milky Way satellite galaxy candidate in the process of
being tidally disrupted as it is accreted by the Galaxy. Two of these stars are
centrally located in the core of the galaxy while the other two stars are
located in the eastern and western tidal tails. The four stars have chemical
abundance patterns consistent with the one previously studied star in Tucana
III: they are moderately enhanced in -process elements, i.e. they have
0.4 dex. The non-neutron-capture elements generally
follow trends seen in other dwarf galaxies, including a metallicity range of
0.44 dex and the expected trend in -elements, i.e., the lower
metallicity stars have higher Ca and Ti abundance. Overall, the chemical
abundance patterns of these stars suggest that Tucana III was an ultra-faint
dwarf galaxy, and not a globular cluster, before being tidally disturbed. As is
the case for the one other galaxy dominated by -process enhanced stars,
Reticulum II, Tucana III's stellar chemical abundances are consistent with
pollution from ejecta produced by a binary neutron star merger, although a
different -process element or dilution gas mass is required to explain the
abundances in these two galaxies if a neutron star merger is the sole source of
-process enhancement.Comment: 18 pages, 10 figures; accepted by Ap
Evidence for Color Dichotomy in the Primordial Neptunian Trojan Population
In the current model of early Solar System evolution, the stable members of
the Jovian and Neptunian Trojan populations were captured into resonance from
the leftover reservoir of planetesimals during the outward migration of the
giant planets. As a result, both Jovian and Neptunian Trojans share a common
origin with the primordial disk population, whose other surviving members
constitute today's trans-Neptunian object (TNO) populations. The cold classical
TNOs are ultra-red, while the dynamically excited "hot" population of TNOs
contains a mixture of ultra-red and blue objects. In contrast, Jovian and
Neptunian Trojans are observed to be blue. While the absence of ultra-red
Jovian Trojans can be readily explained by the sublimation of volatile material
from their surfaces due to the high flux of solar radiation at 5AU, the lack of
ultra-red Neptunian Trojans presents both a puzzle and a challenge to formation
models. In this work we report the discovery by the Dark Energy Survey (DES) of
two new dynamically stable L4 Neptunian Trojans,2013 VX30 and 2014 UU240, both
with inclinations i >30 degrees, making them the highest-inclination known
stable Neptunian Trojans. We have measured the colors of these and three other
dynamically stable Neptunian Trojans previously observed by DES, and find that
2013 VX30 is ultra-red, the first such Neptunian Trojan in its class. As such,
2013 VX30 may be a "missing link" between the Trojan and TNO populations. Using
a simulation of the DES TNO detection efficiency, we find that there are 162
+/- 73 Trojans with Hr < 10 at the L4 Lagrange point of Neptune. Moreover, the
blue-to-red Neptunian Trojan population ratio should be higher than 17:1. Based
on this result, we discuss the possible origin of the ultra-red Neptunian
Trojan population and its implications for the formation history of Neptunian
Trojans
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